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公开(公告)号：RS57700B1
公开(公告)日：2018-12-31
申请号：RSP20181154
申请日：2014-12-12
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
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公开(公告)号：SI3080134T1
公开(公告)日：2018-11-30
申请号：SI201430873
申请日：2014-12-12
Applicant: VERTEX PHARMA
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公开(公告)号：HRP20181563T1
公开(公告)日：2018-11-30
申请号：HRP20181563
申请日：2018-10-01
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , HADIDA-RUAH SARA SABINA , GOLEC JULIAN MARIAN CHARLES , ZHANG BEILI , LITTLER BENJAMIN JOSEPH , KESHAVARZ-SHOKRI ALI , ALCACIO TIM EDWARD , BELMONT DANIEL T
IPC: C07F9/576 , A61K31/675 , A61P19/02
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公开(公告)号：AU2018203149A1
公开(公告)日：2018-05-24
申请号：AU2018203149
申请日：2018-05-07
Applicant: VERTEX PHARMA
Inventor： ZHANG BEILI , ALCACIO TIM EDWARD , LEE ELAINE CHUNGMIN , ZHANG YUEGANG , KRAWIEC MARIUSZ , KESHAVARZ-SHOKRI ALI
IPC: C07D405/12 , A61K31/404 , A61P11/00
Abstract: The present invention relates to solid forms of (R)-I-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5 yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith. -98-
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公开(公告)号：AU2016208341B2
公开(公告)日：2018-05-24
申请号：AU2016208341
申请日：2016-07-27
Applicant: VERTEX PHARMA
Inventor： KESHAVARZ-SHOKRI ALI , ZHANG BEILI , ALCACIO TIM EDWARD , LEE ELAINE CHUNGMIN , ZHANG YUEGANG , KRAWIEC MARIUSZ
IPC: C07D405/12 , A61K31/404 , A61P11/00
Abstract: The present invention relates to solid state forms, for example, crystalline and amorphous forms, of (R)-1-(2,2-difluorobenzo[ d] [ 1,3 ]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1 hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide, pharmaceutical compositions thereof, and methods therewith.
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Patent Agency Ranking
公开(公告)号：CA2706920C
公开(公告)日：2018-02-13
申请号：CA2706920
申请日：2008-12-04
Applicant: VERTEX PHARMA
Inventor： KESHAVARZ SHOKRI ALI , ZHANG BEILI , KRAWIEC MARIUSZ
IPC: C07D405/12 , A61K31/443 , A61P11/00
Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclo-propanecarboxamido)-3- methylPyridin-2-yl)benzoic acid (Form I) of following formula: (I), pharmaceutical compositions thereof, and methods of treatment therewith.
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公开(公告)号：AU2016200431B2
公开(公告)日：2017-08-24
申请号：AU2016200431
申请日：2016-01-26
Applicant: VERTEX PHARMA
Inventor： KESHAVARZSHOKRI ALI , ZHANG BEILI , KRAWIEC MARIUSZ
IPC: C07D405/12 , A61K31/443 , A61P11/00
Abstract: Abstract The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1 (2,2-difluorobenzo [d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin 2yl)benzoic acid (Form I) of following formula: (I), pharmaceutical compositions thereof, and methods of treatment therewith. H(I)
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48.发明专利
公开(公告)号：JOP20190042A1
公开(公告)日：2017-06-16
申请号：JOP20190042
申请日：2019-03-11
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , BAEK MINSON , ZHANG BEILI , UY JOHNNY , ZHOU JINGLAN , JOSHI PRAMOD VIRUPAX , SIESEL DAVID ANDREW , BUSCH BRETT BRADLEY , GROOTENHUIS PETER , VAN GOOR FREDRICK , KESHAVARZ-SHOKRI ALI , MELILLO VITO , HUGHES ROBERT M , ANDERSON COREY , ALCACIO TIMOTHY , PARASELLI PRASUNA , KHATUYA HARIPADA , FRIEMAN BRYAN A , CLEVELAND THOMAS , PIERRE FABRICE JEAN DENIS , KRENITSKY PAUL JOHN , MCCARTNEY JASON , TERMIN ANDREAS P , MCAULEY-AOKI RACHEL , MILLER MARK THOMAS , HADIDA RUAH SARA SABINA
Abstract: ( I )، يتمالكشفعنمركباتلهاالصيغة ( I )،أملاحمقبولةصيدليًامنها،مشتقاتمعالجةبالديوتيريوممنأيٍمماسبق،ونواتجأيضلأيٍمماسبق. كمايتمالكشفعنتركيباتصيدليةتشتملعليها،طرقلعلاجالتليفالكيسيباستخدامها،وطرقلتصنيعها.
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公开(公告)号：ECSP16025201A
公开(公告)日：2017-02-24
申请号：ECPI201625201
申请日：2016-06-13
Applicant: VERTEX PHARMA
Inventor： BELMONT DANIEL , GOLEC JULIAN MARIAN , ALCACIO TIM , ZHANG BEILI , LITTLER BENJAMIN , KESHAVARZ-SHOKRI ALI , ANDERSON COREY , HADIDA-RUAH SARA SABINA
IPC: C07F9/576 , A61K31/675 , A61P19/02
Abstract: La invención se refiere a compuestos profármacos de la fórmula I: en donde R2, R3, R5, R7 y X son como se definen en el presente documento. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos para usar las composiciones en el tratamiento de diversos trastornos, incluyendo dolor. Los compuestos de la fórmula I poseen solubilidad y propiedades fisicoquímicas adecuadas.
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公开(公告)号：HK1217327A1
公开(公告)日：2017-01-06
申请号：HK16105278
申请日：2016-05-10
Applicant: VERTEX PHARMA
Inventor： KESHAVARZSHOKRI ALI , ZHANG BEILI , KRAWIEC MARIUSZ
IPC: C07D20060101 , A61K20060101 , A61P20060101
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