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    올레핀의 비대칭 에폭시화 반응에 유용한 신규의 키랄살렌 유도체
    51.
    发明授权
    올레핀의 비대칭 에폭시화 반응에 유용한 신규의 키랄살렌 유도체 失效
    올레핀의비대칭에폭시화반응에폭규살렌살렌살렌살렌도도도도도

    公开(公告)号：KR100386305B1

    公开(公告)日：2003-06-02

    申请号：KR1020000042858

    申请日：2000-07-25

    Applicant: 한국과학기술연구원 ,  한화화인케미칼 주식회사

    Inventor： 송충의 ,  노은주 ,  유병묵 ,  김수창 ,  채기병 ,  김근식

    IPC: C07C251/24

    Abstract: PURPOSE: Provided are a chiral salen derivative used as a chiral ligand in an asymmetric epoxidation of olefin for producing chiral epoxy compounds and a chiral salen-metal derivative used as a chiral catalyst in the asymmetric epoxidation of olefin. CONSTITUTION: The chiral salen derivative is represented by the formula 1 and the chiral salen-metal derivative is represented by the formula 3, wherein R is C1-C24 straight or branched alkyl, halogen, alcohol, mercapto, or carboxyl-substituted C1-C24 straight or branched alkyl, cycloalkyl, aryl, or heteroaryl, H(1) and H(2) are trans each other, M is a transition metal ion such as Cr, Mn, V, Fe, Mo, W, Ru, Co, Ti, or Os, and A is an anion such as Cl-, CH3COO-, PF6-, or SbF6-.

    Abstract translation: 目的：提供手性salen衍生物作为烯烃的不对称环氧化中的手性配体，用于制备手性环氧化合物和手性salen-金属衍生物，用作烯烃的不对称环氧化中的手性催化剂。 构成：手性salen衍生物由式1表示，手性salen-金属衍生物由式3表示，其中R为C1-C24直链或支链烷基，卤素，醇，巯基或羧基取代的C1-C24 直链或支链烷基，环烷基，芳基或杂芳基，H（1）和H（2）彼此反式，M为过渡金属离子如Cr，Mn，V，Fe，Mo，W，Ru， Ti或Os，A是阴离子，如Cl-，CH3COO-，PF6-或SbF6-。

    4각 고리 질소 화합물, 이를 포함하는 우울증, 정신 질환, 조루증, 또는 신경병증성 통증의 예방 또는 치료용 약학 조성물, 및 상기 약학 조성물을 포함하는 제제
    57.
    发明授权
    4각 고리 질소 화합물, 이를 포함하는 우울증, 정신 질환, 조루증, 또는 신경병증성 통증의 예방 또는 치료용 약학 조성물, 및 상기 약학 조성물을 포함하는 제제 有权
    用于治疗或预防呕吐，精神疾病，预防性呕吐或包括其的神经病性疼痛的药物组合物和包含其的药物的四组分循环氮化合物

    公开(公告)号：KR101426408B1

    公开(公告)日：2014-08-07

    申请号：KR1020130017607

    申请日：2013-02-19

    Applicant: 한국과학기술연구원

    Inventor： 한호규 ,  노은주 ,  송치만 ,  한민수

    IPC: C07D205/04 ,  A61K31/397 ,  A61P25/00

    CPC classification number: C07D205/04 ,  C07D417/12

    Abstract: The present invention relates to a 4-membered cyclic nitrogen compound which can be used as a therapeutic agent or a preventive agent for depression, mental disease, premature ejaculation, or neuropathic pain by preventing re-uptake of certain neurotransmitters with high efficiency; a pharmaceutical composition which can inhibit serotonin and dopamine or norepinephrine re-uptake and has a high therapeutic or prophylactic effect against depression, mental disease, premature ejaculation, or neuropathic pain; and a pharmaceutical formulation comprising the same.

    Abstract translation: 本发明涉及一种4元环状氮化合物，其可以通过防止某些神经递质以高效率的再摄取而用作治疗剂或抑郁症，精神疾病，早泄或神经性疼痛的预防剂。 能够抑制5-羟色胺和多巴胺或去甲肾上腺素再吸收并对抑郁，精神疾病，早泄或神经性疼痛具有高治疗或预防作用的药物组合物; 和含有该制剂的药物制剂。

    (＋)-폴리옥사믹 산의 제조방법
    58.
    发明公开
    (＋)-폴리옥사믹 산의 제조방법 有权
    制备（+） - 多羟基酸的新方法

    公开(公告)号：KR1020140064510A

    公开(公告)日：2014-05-28

    申请号：KR1020120131916

    申请日：2012-11-20

    Applicant: 한국과학기술연구원

    Inventor： 심태보 ,  윤호종 ,  노은주

    IPC: C07C227/12 ,  C07C229/08 ,  C07B33/00

    Abstract: The present invention relates to a novel preparation method of (+)-polyoxamic acid and a novel intermediate compound synthesized while the preparation method is performed. According to the present invention, (+)-polyoxamic acid having a high optical purity can be produced in high yield. Especially, the preparation process is simple and thus can be advantageously used for the mass production.

    Abstract translation: 本发明涉及一种（+） - 聚氧杂恶唑酸的新制备方法和一种在制备方法时合成的新型中间体化合物。 根据本发明，可以高产率制备具有高光学纯度的（+） - 聚氧杂环戊酸。 特别地，制备方法简单，因此可有利地用于批量生产。

    신경보호제로서의 유레아 유도체
    59.
    发明公开
    신경보호제로서의 유레아 유도체 有权
    尿素类似物作为神经保护剂

    公开(公告)号：KR1020130115696A

    公开(公告)日：2013-10-22

    申请号：KR1020120038239

    申请日：2012-04-13

    Applicant: 한국과학기술연구원

    Inventor： 추현아 ,  배애님 ,  김지윤 ,  박병건 ,  이지연 ,  노은주 ,  박정은 ,  라현화

    IPC: C07D211/42 ,  C07D241/28 ,  A61K31/44 ,  A61P25/00

    Abstract: PURPOSE: A urea derivative is provided to selectively suppress the action of mPTP in the brain, thereby being used as a neuroprotective agent which improves the action of the mitochondria. CONSTITUTION: A urea derivative is denoted by chemical formula 1. A method for preparing the urea derivative comprises the steps of making a compound of chemical formula 2 react with isocyanate compounds or isothiocyanate compounds. The compound of chemical formula 2 is prepared by making a compound of chemical formula 3 react with benzyl halide compounds. A pharmaceutical composition for suppressing the action of mPTP contains the urea derivative or a pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for treating nervous diseases contains the urea derivative or a pharmaceutically acceptable salt thereof as an active ingredient.

    Abstract translation: 目的：提供尿素衍生物以选择性抑制脑中mPTP的作用，从而用作改善线粒体作用的神经保护剂。 构成：以化学式1表示脲衍生物。制备尿素衍生物的方法包括使化学式2的化合物与异氰酸酯化合物或异硫氰酸酯化合物反应的步骤。 通过使化学式3的化合物与苄基卤化合物反应来制备化学式2的化合物。 用于抑制mPTP作用的药物组合物含有尿素衍生物或其药学上可接受的盐作为活性成分。 用于治疗神经疾病的药物组合物含有尿素衍生物或其药学上可接受的盐作为活性成分。

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