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    염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(Ｎ-메틸치환술폰아미도)메틸-2Ｈ-1-벤조피란 유도체
    53.
    发明公开
    염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(Ｎ-메틸치환술폰아미도)메틸-2Ｈ-1-벤조피란 유도체 失效
    6-氨基亚氨基-2-甲基-2' - （N-甲基取代的磺酰胺）甲基-2H-1-苯并噻吩衍生物作为抗炎抑制剂

    公开(公告)号：KR1020070024838A

    公开(公告)日：2007-03-08

    申请号：KR1020050080383

    申请日：2005-08-30

    Applicant: 한국화학연구원

    Inventor： 공영대 ,  천혜경 ,  전문국 ,  조영식 ,  황종연 ,  최형섭 ,  전현숙 ,  황순희 ,  송진숙 ,  김지현 ,  유성은

    IPC: C07D311/70 ,  C07D409/12 ,  C07D401/12

    CPC classification number: C07D311/58 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14

    Abstract: A novel 6-alkylamino-2-methyl-2-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative is provided to show excellent 5-lipoxygenase(5-LO) inhibition effect, thereby being used for preventing and treating inflammatory diseases induced by related leukotrien(LTA4, B4, C4, D4), rheumatoid arthritis, colitis, asthma, and psoriasis. The 6-alkylamino-2-methyl-2-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative is represented by the formula(1), where R^1 is C1-10 alkyl; phenyl; phenyl substituted by a substituent selected from the group consisting of C1-6 alkyl, C1-6 acyloxy, C1-10 alkoxyalkyl, and C1-10 dialkoxyalkyl; benzyl; benzyl substituted by a substituent selected from the group consisting of halogen, nitro, cyano, hydroxy, C1-6 alkyl and C1-6 alkoxy; phenethyl; pyridyl methyl; thiophene methyl; or thiophene methyl substituted by C1-6 alkyl, each R^2 and R^3 is independently H; or C1-6 alkyl, and R^4 is C1-10 alkyl; phenyl; phenyl substituted by a substituent selected from the group consisting of C1-6 alkyl and C1-6 alkoxy; or thiophene. The anti-inflammatory agent comprises the 6-alkylamino-2-methyl-2-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative represented by the formula(1).

    Abstract translation: 提供新的6-烷基氨基-2-甲基-2-（N-甲基取代亚磺酰氨基）甲基-2H-1-苯并吡喃衍生物，以显示出优异的5-脂氧合酶（5-LO）抑制作用，从而用于预防和治疗 由相关白细胞介素（LTA4，B4，C4，D4），类风湿关节炎，结肠炎，哮喘和牛皮癣引起的炎性疾病。 6-烷基氨基-2-甲基-2-（N-甲基取代亚磺酰氨基）甲基-2H-1-苯并吡喃衍生物由式（1）表示，其中R 1是C 1-10烷基; 苯基; 被选自C 1-6烷基，C 1-6酰氧基，C 1-10烷氧基烷基和C 1-10二烷氧基烷基的取代基取代的苯基; 苄基; 被选自卤素，硝基，氰基，羟基，C 1-6烷基和C 1-6烷氧基的取代基取代的苄基; 苯; 吡啶基甲基; 噻吩甲基; 或被C 1-6烷基取代的噻吩甲基，每个R 2和R 3独立地为H; 或C 1-6烷基，R 4是C 1-10烷基; 苯基; 被选自C 1-6烷基和C 1-6烷氧基的取代基取代的苯基; 或噻吩。 抗炎剂包含式（1）表示的6-烷基氨基-2-甲基-2-（N-甲基取代亚磺酰氨基）甲基-2H-1-苯并吡喃衍生物。

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