公开(公告)号：UY31881A

公开(公告)日：2010-01-29

申请号：UY31881

申请日：2009-06-09

Applicant: ABBOTT LAB

Inventor： ERICSSON ANNA M ,  DAVID CALDERWOOD ,  WISHART NEIL ,  STEWART KENT D ,  ARGIRIADI MARIA A ,  FIAMENGO BRYAN R ,  FRANK CRISTINE E ,  MICHAEL FRIEDMAN ,  GEORGE DAWN M ,  GOEDKEN ERIC R ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  MORYTKO MICHAEL J ,  VOSS JEFFREY W ,  WALLACE GRIERE A ,  LU WANG ,  WOLLER KEVIN R

IPC: A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  C07D209/00 ,  C07D233/00 ,  C07D235/00 ,  C07D241/00 ,  C07D249/00 ,  C07D401/00

Abstract: Un compuesto de la fórmula (I) sales, prodrogas, metabolitos biológicamente activos, estereoisómeros e isómeros farmacéuticamente aceptables del mismo, en donde las variables se definieron en la presente. Los compuestos de la invención son de utilidad para el tratamiento de condiciones inmunológicas y oncológicas.

公开(公告)号：CA2727032A1

公开(公告)日：2009-12-17

申请号：CA2727032

申请日：2009-06-09

Applicant: ABBOTT LAB

Inventor： WISHART NEIL ,  ARGIRIADI MARIA A ,  CALDERWOOD DAVID J ,  ERICSSON ANNA M ,  FIAMENGO BRYAN A ,  FRANK KRISTINE E ,  FRIEDMAN MICHAEL ,  GEORGE DAWN M ,  GOEDKEN ERIC R ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  MORYTKO MICHAEL J ,  STEWART KENT D ,  VOSS JEFFREY W ,  WALLACE GRIER A ,  WANG LU ,  WOLLER KEVIN R

IPC: C07D487/14 ,  A61K31/438 ,  A61K31/4985 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：AU2009257602A1

公开(公告)日：2009-12-17

申请号：AU2009257602

申请日：2009-06-09

Applicant: ABBOTT LAB

Inventor： CALDERWOOD DAVID J ,  WISHART NEIL ,  WOLLER KEVIN R ,  JOSEPHSOHN NATHAN S ,  ERICSSON ANNA M ,  FIAMENGO BRYAN A ,  ARGIRIADI MARIA A ,  WANG LU ,  GEORGE DAWN M ,  FRIEDMAN MICHAEL ,  STEWART KENT D ,  VOSS JEFFREY W ,  GOEDKEN ERIC R ,  MORYTKO MICHAEL J ,  LI BIQIN C ,  FRANK KRISTINE E ,  WALLACE GRIER A

IPC: A01N43/42

Abstract: The invention provides a compound of Formula (Ie), pharmaceutically acceptable salts, prodrugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：CA2662701A1

公开(公告)日：2008-10-23

申请号：CA2662701

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： KUMAR SHANKAR ,  HINTON PAUL R ,  WU CHENGBIN ,  CUFF CAROLYN A ,  MELIM TERRY L ,  DIXON RICHARD W ,  BELK JONATHAN P ,  CHEN YAN ,  ARGIRIADI MARIA A ,  YING HUA

IPC: C07K16/24 ,  C07K16/46 ,  C12N15/13 ,  C12P21/08

Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and human ized antibodies. Preferred antibodies have high affinity for hIL-13 and neut ralize hIL-13 activity in vitro and in vivo. An antibody of the invention ca n be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provide d. The antibodies, or antibody portions, of the invention are useful for det ecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject s uffering from a disorder in which hTL-13 activity is detrimental.