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公开(公告)号：CA2356320A1
公开(公告)日：2000-07-06
申请号：CA2356320
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： LINK JAMES , PEI ZHONGHUA , GUNAWARDANA INDRANI W , LIU GANG , FREEMAN JENNIFER C , ZHU GUI-DONG , BOYD STEVEN A , JAE HWAN-SOO , XIN ZHILI , WINN MARTIN , LYNCH JOHN K , VON GELDERN TOM , STAEGER MICHAEL A
IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/10 , C07D295/20 , A61K31/33
Abstract: The present invention relates to novel cinnamide compounds that are useful f or treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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52.发明专利
公开(公告)号：NZ331124A
公开(公告)日：2000-05-26
申请号：NZ33112497
申请日：1997-02-10
Applicant: ABBOTT LAB
Inventor： TASKER ANDREW S , BOYD STEVEN A , SORENSEN BRYAN K , WINN MARTIN , JAE HWAN-SOO , VON GELDERN THOMAS W , HENRY KENNETH J
IPC: A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/675 , A61P1/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P25/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07F9/572
Abstract: A compound of above formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof. The compounds have use in and a method of antagonizing endothelin and therefore in the treatment of hypertension, congestive heart failure cerebral or myocardial ischemia and artherosclerosis. Specific compounds claimed are exemplified by: Trans,trans-2-(4-propoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1((2,6-diethyl)phenylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid; [2R,3R,4S]2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N-((2,6-diethyl)phenylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid; [2R,3R,4S]2-(4-propoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N-((2,6-diethyl)phenylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid; and [2R,3R,4S]2-(4-ethoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N-((2,6-diethyl)phenylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid;
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公开(公告)号：NO20000542L
公开(公告)日：2000-04-04
申请号：NO20000542
申请日：2000-02-02
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY ALAN , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056 , A61K
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公开(公告)号：NO20000542A
公开(公告)日：2000-04-04
申请号：NO20000542
申请日：2000-02-02
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY ALAN , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056 , A61K
CPC classification number: C07D207/27 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14
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55.发明专利
公开(公告)号：AU714597B2
公开(公告)日：2000-01-06
申请号：AU2267897
申请日：1997-02-10
Applicant: ABBOTT LAB
Inventor： TASKER ANDREW S , BOYD STEVEN A , SORENSEN BRYAN K , WINN MARTIN , JAE HWAN-SOO , GELDERN THOMAS W VON , HENRY KENNETH J JR
IPC: A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/675 , A61P1/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P25/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07F9/572
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Patent Agency Ranking
公开(公告)号：ZA985209B
公开(公告)日：1999-01-06
申请号：ZA985209
申请日：1998-06-15
Applicant: ABBOTT LAB
Inventor： TASKER ANDREW S , WINN MARTIN , BOYD STEVEN A , JAE HWAN-SOO , VONGELDERN THOMAS W , SORENSEN BRYAN K , HENRY KENNETH J
IPC: C07D207/16 , C07D405/04 , C07D , A61K , C07F
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公开(公告)号：AU7826398A
公开(公告)日：1999-01-04
申请号：AU7826398
申请日：1998-06-08
Applicant: ABBOTT LAB
Inventor： TASKER ANDREW S , WINN MARTIN , BOYD STEVEN A , JAE HWAN-SOO , GELDERN THOMAS W VON , SORENSEN BRYAN K , HENRY KENNETH J JR
IPC: C07D207/16 , C07D405/04 , A61K31/40
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58.发明专利
公开(公告)号：AU2262097A
公开(公告)日：1997-09-02
申请号：AU2262097
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J JR , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/506 , A61K31/675 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P25/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07D471/04 , C07D491/04 , C07F9/572 , C07F9/59
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号：ZA9701184B
公开(公告)日：1997-08-27
申请号：ZA9701184
申请日：1997-02-12
Applicant: ABBOTT LAB
Inventor： TASKER ANDREW S , VONGELDERN THOMAS W , JAE HWAN-SOO , SORENSEN BRYAN K , WINN MARTIN , BOYD STEVEN A , HENRY KENNETH J
IPC: A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/675 , A61P1/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P25/04 , A61P35/00 , A61P43/00 , C07D20060101 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D453/02 , C07F9/572 , C07D , A61K , C07F
CPC classification number: C07D405/04 , A61K9/2059 , A61K9/4866
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公开(公告)号：AU2008201198A1
公开(公告)日：2008-04-03
申请号：AU2008201198
申请日：2008-03-12
Applicant: ABBOTT LAB
Inventor： SZCZEPANKIEWICZ BRUCE G , WITTENBERGER STEVEN J , JAE HWAN-SOO , BOYD STEVEN A , KESTER JEFFREY A , KING STEVEN A , WINN MARTIN , HENRY KENNETH J , LIU GANG , TASKER ANDREW S , HUTCHINS CHARLES W , SORENSEN BRYAN K , GELDEM THOMAS W VON
IPC: C07D405/00
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