公开(公告)号：DE19928549A1

公开(公告)日：2001-01-18

申请号：DE19928549

申请日：1999-06-22

Applicant: BASF AG

Inventor： KOSER STEFAN ,  MUNDINGER KLAUS ,  KASEL WOLFGANG ,  KINGMA AREND JOUKE ,  DOCKNER TONI

IPC: B01J31/24 ,  C07B61/00 ,  C07C41/03 ,  C07C43/23 ,  C07C43/20 ,  C07F9/50

Abstract: Preparation of bisphenol alkoxylates comprises reacting bisphenol(s) with an alkylene oxide in the presence of a phosphine catalyst free from alkali metal hydroxide. An Independent claim is also included for the use of specified triaryl-phosphine catalysts in the preparation of bisphenol alkoxylates.

公开(公告)号：AU6264900A

公开(公告)日：2001-01-09

申请号：AU6264900

申请日：2000-06-21

Applicant: BASF AG

Inventor： KOSER STEFAN ,  MUNDINGER KLAUS ,  KASEL WOLFGANG ,  KINGMA AREND JOUKE ,  DOCKNER TONI

IPC: B01J31/24 ,  C07B61/00 ,  C07C41/03 ,  C07C43/23

Abstract: Preparation of bisphenol alkoxylates comprises reacting bisphenol(s) with an alkylene oxide in the presence of a phosphine catalyst free from alkali metal hydroxide. An independent claim is also included for the use of specified triaryl-phosphine catalysts in the preparation of bisphenol alkoxylates.

公开(公告)号：CO4960663A1

公开(公告)日：2000-09-25

申请号：CO98046527

申请日：1998-08-13

Applicant: BASF AG

Inventor： BLECH STEFAN ,  DOROTHEA STARCK ,  TREIBER HANS-JORG ,  KOSER STEFAN ,  SCHAFER BERND ,  THYES MARCO ,  HOGER THOMAS

IPC: C07D239/56 ,  A61K20060101 ,  A61K31/185 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: Sal de ácido fumárico de 2-{3-[4-(2-t-butil-6-trifluorome-tilpirimidin-4-il)piperazin-1-il]propilmercapto} pirimidin-4-ol de la fórmula y las formas tautómeras, solvatos e hidratos de la misma. Medicamento que contiene la sal de ácido fumárico o una forma tautómera, un solvato o un hidrato de la misma de acuerdo con la cláusula 1, CARACTERIZADO porque puede administrarse, en caso necesario, junto con portadores y/o sustancias auxiliares fisiológicamente aceptables. Sal de ácido fumárico o una forma tautómera, un solvato o hidrato de la misma de acuerdo con la claúsula 1 utilizada para preparar un medicamento para el tratamiento de enfermedades que responden a la acción de ligandos de dopamina D3 .

公开(公告)号：SK1182000A3

公开(公告)日：2000-09-12

申请号：SK1182000

申请日：1998-08-14

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  KOSER STEFAN ,  SCHAFER BERND ,  THYES MARCO ,  HOGER THOMAS

IPC: A61K20060101 ,  A61K31/395 ,  C07D239/56 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.

公开(公告)号：ZA987239B

公开(公告)日：2000-02-14

申请号：ZA987239

申请日：1998-08-13

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  KOSER STEFAN ,  SCHAEFER BERND ,  THYES MARCO ,  HOEGER THOMAS

IPC: A61K20060101 ,  A61K31/395 ,  A61K31/497 ,  C07D239/56 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14 ,  C07D ,  A61K

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.

公开(公告)号：HUT78040A

公开(公告)日：1999-06-28

申请号：HU9603474

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：CA2301297A1

公开(公告)日：1999-02-25

申请号：CA2301297

申请日：1998-08-14

Applicant: BASF AG

Inventor： SCHAFER BERND ,  STARCK DOROTHEA ,  BLANK STEFAN ,  THYES MARCO ,  TREIBER HANS-JORG ,  KOSER STEFAN ,  HOGER THOMAS

IPC: C07D239/56 ,  A61K20060101 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The invention relates to the fumaric acid salt from 2-{3-4-(2-T-butyl-6-trifluoromethylpyridin-4-yl) piperazin-1-yl! propylmercapto} pyrimidin-4-ol and to pharmaceutical agents containing said salt. The salt can be used for treating diseases which respond to dopamine-D3 ligands. It is very stable at a low pH and is therefore especially suitable for oral administration.

公开(公告)号：CA2222854A1

公开(公告)日：1998-06-23

申请号：CA2222854

申请日：1997-12-22

Applicant: BASF AG

Inventor： ISOLA ARTHUR MARK ,  KLINTZ RALF ,  KOSER STEFAN ,  WATTS JOHN PAUL ,  MUENSTER PETER ,  HOLMAN NICHOLAS JOHN ,  TOMETZKI GERALD BERNARD

IPC: C07B63/02 ,  C07C41/44 ,  C07C43/225 ,  C07C45/72 ,  C07C45/85 ,  C07C49/255 ,  C07C201/16 ,  C07C205/56 ,  C07D209/08 ,  C07D209/10 ,  C07D209/48 ,  C07D235/18 ,  C07D319/06 ,  C07D487/04 ,  C07D209/42 ,  C07C41/58

Abstract: A process for reducing the level of tri-substituted phosphine, arsine and/or stibine oxide from a mixture comprising a desired product and at least one such oxide is provided, comprising the addition of a metal salt to the mixture to form a complex with the oxide, and removing the complex from the mixture. This process has particular utility for removing triphenylphosphine oxide from a mixture - a task that was previously hard to perform.

公开(公告)号：BR9509970A

公开(公告)日：1997-11-25

申请号：BR9509970

申请日：1995-11-25

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HEMULT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

公开(公告)号：NO973764A

公开(公告)日：1997-10-15

申请号：NO973764

申请日：1997-08-15

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

CPC classification number: C07D213/78 ,  C07D205/04 ,  C07D207/16 ,  C07D239/28 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06165