公开(公告)号：DE4010097A1

公开(公告)日：1991-10-02

申请号：DE4010097

申请日：1990-03-29

Applicant: BASF AG

Inventor： MAY HANS-JOACHIM DR ,  RASCHACK MANFRED DR ,  SCHULT SABINE DR

IPC: A61K31/41 ,  A61P9/00 ,  A61P9/12 ,  C07D498/04

Abstract: Compounds of formula (I), where R to R , X, Y and Z have the indicated meaning, and their production are described. The compounds are useful therapeutic agents.

公开(公告)号：DE3825559A1

公开(公告)日：1990-02-01

申请号：DE3825559

申请日：1988-07-28

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  RASCHACK MANFRED DR ,  PHILIPSBORN GERDA VON DR MED

IPC: A61K31/135 ,  A61K31/13 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61P9/06 ,  C07C217/22 ,  C07D295/08 ,  C07D295/092

Abstract: p-Hydroxyphenone derivatives of the general formula I … … in which R , R and R are identical or different and are methyl, chlorine, bromine and hydrogen, where R , R and R are not all H, R and R are identical or different and are H, C1-C4-alkyl or OR , where R and R are not both H, X is a -CH=CH-, -CH2CH2- and -CH2-bridge, Y is a straight-chain or branched, saturated or unsaturated C1-C4-bridge and Z is the radical NR R , where R and R are, independently of one another, hydrogen or C1-C4-alkyl, or Z is a 5- or 6-membered ring with a nitrogen atom in position 1 and, where appropriate, additionally a second N or an O or S atom, where the second N atom is substituted by R , the physiologically tolerated salts thereof, and medicaments prepared therefrom and the use thereof as Vaughan-Williams Class III antiarrhythmic.

公开(公告)号：DE3665861D1

公开(公告)日：1989-11-02

申请号：DE3665861

申请日：1986-11-26

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  BALDINGER VERENA DR ,  GRIES JOSEF DR ,  LENKE DIETER PROF DR ,  RASCHACK MANFRED DR ,  RUEBSAMEN KLAUS DR

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C95/08

公开(公告)号：DE3462688D1

公开(公告)日：1987-04-23

申请号：DE3462688

申请日：1984-12-10

Applicant: BASF AG

Inventor： KREISKOTT HORST PROF DR ,  SEITZ WERNER DR ,  RASCHACK MANFRED DR

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07C121/66

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.

公开(公告)号：AT25969T

公开(公告)日：1987-04-15

申请号：AT84115038

申请日：1984-12-10

Applicant: BASF AG

Inventor： RASCHACK MANFRED DR ,  KREISKOTT HORST PROF DR PHARMA ,  SEITZ WERNER DR CHEMIKER

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07C121/66

公开(公告)号：AT17845T

公开(公告)日：1986-02-15

申请号：AT82108292

申请日：1982-09-09

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DR ,  MUELLER JOSEF DR ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT DR ,  HEGE HANS-GUENTHER DR ,  MUELLER CLAUS D DR ,  GRIES JOSEF DR ,  LENKE DIETER DR ,  VON PHILIPSBORN GERDA DR ,  RASCHACK MANFRED DR

IPC: A61K31/13 ,  A61K31/445 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07C93/06 ,  C07C93/14 ,  C07C149/24

公开(公告)号：GR75531B

公开(公告)日：1984-07-26

申请号：GR820167618

申请日：1982-03-17

Applicant: BASF AG

Inventor： EHRMANN ODKAR DR ,  RASCHACK MANFRED DR ,  GRIES JOSEF DR ,  KRETZSCHMAR ROLF DR ,  LEHMANN HANS DIETER DR ,  FRIEDRICH LUDWIC DR ,  WUPPERMANN DIRK DR ,  ZIMMERMANN FRANK DR ,  SEITZ WERNER DR ,  TREIBER HANS JOERG DR ,  DENGEL FERDINAUD DR ,  FRANK WOLFRAM DR

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18

公开(公告)号：DE19750529A1

公开(公告)日：1999-05-20

申请号：DE19750529

申请日：1997-11-14

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  JANSEN ROLF DR ,  HILLEN HEINZ DR ,  HERGENROEDER STEFAN DR ,  RASCHACK MANFRED DR ,  UNGER LILIANE DR

IPC: C07D249/12 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/433 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D231/20 ,  C07D233/70 ,  C07D261/12 ,  C07D263/38 ,  C07D271/06 ,  C07D271/10 ,  C07D273/01 ,  C07D275/02 ,  C07D275/03 ,  C07D277/20 ,  C07D277/32 ,  C07D277/34 ,  C07D277/60 ,  C07D277/68 ,  C07D285/00 ,  C07D285/08 ,  C07D285/12 ,  C07D291/04 ,  C07D413/12 ,  C07D417/12 ,  C07D263/20 ,  C07D277/72 ,  C07D263/46

Abstract: Heterocyclic alpha -hydroxycarboxylic acid derivatives (I) are new. Heterocyclic alpha -hydroxycarboxylic acid derivatives of formula (I) and their salts, enantiomers and diastereomers are new. R = tetrazolyl or CO-R; R = OR , a 5-membered heteroaromatic group bound via an N atom, -O-(CH2)p-S(O)k-R or -NH-SO2-R ; A = NR R , N3, OR , SR or 1-4C alkyl; X = O, S, CR or NR , provided that if X = CR , then Y = O, S or NR ; Y = O, S, CR or NR ; R , R = independently phenyl or naphthyl (which are optionally substituted or optionally bound via a methylene, ethylene, ethenylene, O, S, SO2, NH or N(1-4C alkyl) group) or 5- or 6C cycloalkyl; R , R = H, halo, or optionally substituted 1-4C alkoxy, 1-4C haloalkoxy, 3-6C alkenyloxy, 3-6C alkynyloxy, 1-4C alkylthio, (1-4C alkyl)carbonyl, (1-4C alkoxy)carbonyl, OH, NH2, NH(1-4C alkyl), N(1-4C alkyl)2, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, or CR and CR together form a 5- or 6-membered alkylene or alkenylene ring, which is optionally substituted and one or more of whose CH2 groups may be replaced by O, S, NH or N(1-4C alkyl); R = H, an alkali or alkaline earth metal cation or an organic ammonium ion, or 3-8C cycloalkyl, 1-8C alkyl, benzyl, 3-8C alkenyl, 3-8C alkynyl or optionally substituted phenyl; k = 0-2; p = 1-4; R = 1-4C alkyl, 3-8C cycloalkyl, 3-8C alkenyl, 3-8C alkynyl or optionally substituted phenyl; R = 1-4C alkyl, 3-8C cycloalkyl, 3-8C alkenyl, 3-8C alkynyl, 1-4C haloalkyl or phenyl (all optionally substituted); R = H, 1-8C alkyl, 3-8C alkenyl, 3-8C alkynyl or (1-5C alkyl)carbonyl, phenyl, naphthyl or 3-8C cycloalkyl (all optionally substituted), or R and R together form a 3-7C alkylene chain which may be substituted and whose alkylene chain may contain O or S atoms; R = H or 1-4C alkyl; R = H, 1-8C alkyl, 3-8C alkenyl, 3-8C alkynyl, phenyl, naphthyl or 3-8C cycloalkyl (all optionally substituted); R = H or 1-4C alkyl, or NR and CR together form a 5- or 6-membered alkylene or alkenylene ring, which is optionally substituted and one or more of whose CH2 groups may be replaced by O or S; R = H, halo, 1-4C alkyl, 2-4C alkenyl or 2-4C alkynyl (all optionally substituted); R = H or 1-4C alkyl.

公开(公告)号：DE19726146A1

公开(公告)日：1998-12-24

申请号：DE19726146

申请日：1997-06-19

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  HERGENROEDER STEFAN DR ,  RASCHACK MANFRED DR ,  UNGER LILIANE DR

IPC: C07D251/16 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61P7/02 ,  A61P9/02 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C247/12 ,  C07D213/68 ,  C07D237/14 ,  C07D237/16 ,  C07D239/34 ,  C07D239/52 ,  C07D239/56 ,  C07D239/60 ,  C07D239/70 ,  C07D239/80 ,  C07D239/95 ,  C07D241/18 ,  C07D251/22 ,  C07D251/34 ,  C07D251/52 ,  C07D253/06 ,  C07D403/12 ,  C07D491/048 ,  C07D239/28 ,  C07D237/10 ,  C07D251/12 ,  C07D257/08 ,  C07D213/60 ,  A61K31/44

Abstract: The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin receptor antagonists.

公开(公告)号：CZ9801045A3

公开(公告)日：1998-09-16

申请号：CZ104598

申请日：1996-09-26

Applicant: BASF AG

Inventor： KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  RIECHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/505 ,  A61K31/53 ,  A61P5/24 ,  A61P5/36 ,  A61P5/42 ,  A61P9/12 ,  C07D213/74 ,  C07D239/10 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D239/52 ,  C07D239/58 ,  C07D251/46 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D491/056 ,  C07D239/70 ,  C07D251/42 ,  C07D487/02

CPC classification number: C07D213/74 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D239/58 ,  C07D251/46