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    External preparation for skin
    51.
    发明专利
    External preparation for skin 有权

    公开(公告)号：JP2004189740A

    公开(公告)日：2004-07-08

    申请号：JP2003408899

    申请日：2003-12-08

    Applicant: Kao Corp ,  花王株式会社

    Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  TAKEMA YOSHINORI ,  FUJIMURA TSUTOMU ,  IMOKAWA GENJI

    IPC: A61K8/30 ,  A61K8/02 ,  A61K8/06 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/55 ,  A61K8/58 ,  A61K8/60 ,  A61K7/00

    Abstract: PROBLEM TO BE SOLVED: To provide an external preparation for skin, having an excellent effect of preventing/improving wrinkles, making the skin maintain its normal function, and excellent in a dandruff-resisting effect and an effect of improving the skin after sunburned.
    SOLUTION: This external preparation for skin contains an amine derivative expressed by general formula (1) (R
    1 is a 1-40C hydrocarbon radical which may contain one or more hetero atoms; R
    2 and R
    3 are each a 1-3C bivalent hydrocarbon radical; R
    4 is H or a 1-3C hydrocarbon radical; R
    5 is H, a 1-3C hydrocarbon radical or -P(O)(OH)
    2 ; R
    6 is H or a 1-3C hydrocarbon radical which may have one or more hydroxy group; and Y is a 1-10C hydrocarbon radical which has one or more radicals, such as hydroxy group, alkoxy group, phosphate and carboxyl group) or general formula (2) (R
    7 and R
    8 are each a 1-3C hydrocarbon radical which may have one to three hydroxy groups).
    COPYRIGHT: (C)2004,JPO&NCIPI

    SKIN LOTION
    52.
    发明专利
    SKIN LOTION 失效

    公开(公告)号：JP2000007631A

    公开(公告)日：2000-01-11

    申请号：JP8168599

    申请日：1999-03-25

    Applicant: KAO CORP

    Inventor： FUJIMORI TAKETOSHI ,  YAMAMURO AKIRA ,  FUJIKURA YOSHIAKI ,  HIGUCHI KAZUHIKO ,  HORI KIMIHIKO ,  IMOKAWA GENJI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K8/42 ,  A61K31/16 ,  A61P17/00 ,  A61Q19/00 ,  C07C217/28 ,  C07C233/18 ,  A61K7/00 ,  A61K7/48

    Abstract: PROBLEM TO BE SOLVED: To obtain a new amido derivative having an excellent improving effect on a trouble caused by dyskeratosis of the skin. SOLUTION: This amido derivative is shown by formula I [R1 is a (substituted) 4-20C alkyl; R2 is a 1-7C alkyl; R3 is H or 2,3-dihydroxypropyl; R4 is a 2-4C alkylene] such as a compound of formula II. The compound of formula I is, for example, obtained by reacting an alcohol with epichlorohydrin in the presence of a phase transfer catalyst such as a quaternary ammonium salt or the like (e.g. tetrabutyl ammonium bromide or the like) and a base at preferably 20-80 deg.C for 1-12 hrs to form glycidyl ether, reacting the glycidyl ether with an amine derivative of formula H2N-R4 OCH3 at preferably 20-150 deg.C for 2-8 hrs to form an intermediate of formula III and reacting the resulting intermediate of formula III with an ester such as methyl propionate at preferably 15-100 deg.C for 2-8 hrs. Preferably, an external preparation contains 0.01-10 wt.% the above compound.

    HAIR-GROWING INHIBITOR
    53.
    发明专利
    HAIR-GROWING INHIBITOR 失效

    公开(公告)号：JPH11106321A

    公开(公告)日：1999-04-20

    申请号：JP27087497

    申请日：1997-10-03

    Applicant: KAO CORP

    Inventor： TSUJI NAOKO ,  MORIWAKI SHIGERU ,  TAKEMA YOSHINORI ,  KANAZAWA SATOSHI ,  NISHIZAWA YOSHINORI ,  IMOKAWA GENJI

    IPC: A61K8/00 ,  A61K8/97 ,  A61Q7/02 ,  A61Q9/04 ,  A61K7/155

    Abstract: PROBLEM TO BE SOLVED: To obtain a hair-growing inhibitor which shows excellent hair-growing inhibitory activity and is high in the safety by formulating a specific plant extract thereto. SOLUTION: This inhibitor contains an extract from a plant selected from ginger, hydrolyzed almond, burnet, clove, rose fruit, hawthorn, white birch and gambir in an amount of 0.0001-50 wt.%, preferably 0.001-10 wt.%, as the dry solid. The above-stated plant extract other than the hydrolyzed almond is an extract obtained by extracting crushed pieces of the above-stated plants with various solvents or by the use of extraction tools, its diluent, its concentrate or its dried powder, and the hydrolyzed almond is obtained by immersing silk fibers into a mixture of an acid or an alkali and water and/or ethanol usually at 3-100 deg.C and then removing insoluble matters.

    PREVENTIVE FOR WRINKLE FORMATION
    55.
    发明专利
    PREVENTIVE FOR WRINKLE FORMATION 失效

    公开(公告)号：JPH10265359A

    公开(公告)日：1998-10-06

    申请号：JP7169897

    申请日：1997-03-25

    Applicant: KAO CORP

    Inventor： TSUJI NAOKO ,  MORIWAKI SHIGERU ,  IMOKAWA GENJI ,  SUZUKI YASUTO ,  NISHIZAWA YOSHINORI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/49 ,  A61K8/55 ,  A61K8/58 ,  A61K8/98 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/48 ,  A61K7/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a preventive for wrinkle formation, capable of preventing and improving the occurrence of wrinkle caused by aging of skin by including a metal-dependent elastin decomposing inhibitor as an active ingredient. SOLUTION: This medicine comprises a metal-dependent elastin decomposing inhibitor, especially a metal-dependent elastin decomposing inhibitor derived from a fibroblast of corium, such as a phosphonic acid derivative or a mercaptopropionamide derivative as an active ingredient. The medicine is further formulated with an ultraviolet absorber or an ultraviolet controller to preferably prepare a skin preparation for external use. The formulated amount of the metal-dependent elastin decomposing enzyme inhibitor in the case of preparing the skin preparation for external use is preferably 0.0001-5 wt.% based on the whole composition. The elastin decomposing enzyme includes one belonging to a serine protease and one belonging to a metal-dependent protease. An elastase inhibitor belonging to the metal protease has excellent controlling action on wrinkle formation.

    GRAY HAIR PREVENTIVE AGENT
    56.
    发明专利
    GRAY HAIR PREVENTIVE AGENT 失效

    公开(公告)号：JPH1095716A

    公开(公告)日：1998-04-14

    申请号：JP26771096

    申请日：1996-09-19

    Applicant: KAO CORP

    Inventor： OKAMOTO YOSHIMASA ,  KOBAYASHI TAKESHI ,  IMOKAWA GENJI

    IPC: A61K8/00 ,  A61K8/49 ,  A61K31/40 ,  A61P43/00 ,  A61Q5/00 ,  A61K7/06

    Abstract: PROBLEM TO BE SOLVED: To obtain a grain hair preventive agent excellent in not only effects for prevention of generation of gray hairs and reform of the gray hairs but also safety by using a specific phosphodiesterase inhibitor as an active ingredient. SOLUTION: Among various inhibitors against phosphodiesterase (hereinafter written briefly as PDE) which is an enzyme decomposing cAMP, PDE IV type selective inhibitors [however, 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone is excluded] are used. As the PDE type selective inhibitors, compounds of the formula (R1 and R2 are each H, OH, COOH, an alkyl, an alkenyl, an alkoxy and carboxymethyloxy; R3 is H, an alkyl and an alkenyl) or their salts are preferable. Among them, rolipram, namely 4-(3-cyclopentyloxy-4- methoxyphenyl)-2-pyrrolidinone, or its salt is suitable. The inhibitors are preferably formulated in an amount of about 0.01-10wt.%, particularly about 0.05-5wt.%, based on the whole composition.

    COMPOSITION FOR EXTERNAL USE IN SCALP
    59.
    发明专利
    COMPOSITION FOR EXTERNAL USE IN SCALP 失效

    公开(公告)号：JPH0840840A

    公开(公告)日：1996-02-13

    申请号：JP17639894

    申请日：1994-07-28

    Applicant: KAO CORP

    Inventor： KOBAYASHI HISATAKA ,  KUDOU MICHIMASA ,  IMOKAWA GENJI ,  OKUDA MINEHIRO

    IPC: A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/49 ,  A61K31/13 ,  A61K31/14 ,  A61K31/44 ,  A61P17/00 ,  A61P31/04 ,  A61Q5/00 ,  A61Q5/02 ,  A61K7/06

    Abstract: PURPOSE:To obtain a composition for external use in the scalp capable of manifesting ultrahigh suppressing effects on dandruff and pruritus and further excellent in persistence of the effects by using an antimicrobial agent used for the purpose of preventing the dandruff and pruritus with a keratinization improving agent. CONSTITUTION:This composition for external use in the scalp is obtained by using an antimicrobial agent which is a preventing agent for dandruff and pruritus and a keratinization improving agent comprising an amine derivative of formula I [R is a 4-40C straight-chain, branched chain or cyclic saturated or unsaturated hydrocarbon; R to R are each H or a 1-10C hydrocarbon (which can be substituted with OH)] or its acid addition salt in combination. An antimicrobial agent selected from a polyvalent metallic salt of 2- mercaptopyridine N-oxide, a 1-hydroxy-2-pyrrolidone derivative of formula II (R is an alkyl, an alkenyl, a cycloalkyl, etc.; R is H, an alkyl, an alkenyl, etc.; X is an organic salt group, a cation, etc.), 2,2'-dithio-bis-(pyridine N-oxide) of formula III and a benzalkonium salt of formula IV (R is a hydrocarbon; Y is an anion residue such as a phosphoric ester) is especially preferred as the antimicrobial agent.

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