公开(公告)号：SI2193196T1

公开(公告)日：2017-01-31

申请号：SI200831678

申请日：2008-09-26

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: A61K38/00 ,  A61K39/00 ,  A61P7/00 ,  C12N9/00

公开(公告)号：PT2513058T

公开(公告)日：2017-01-26

申请号：PT10801495

申请日：2010-12-15

Applicant: MILLENNIUM PHARM INC ,  PORTOLA PHARM INC

Inventor： ANJALI PANDEY ,  EMILIA P T LEITAO ,  JOSE RATO ,  ZHIGUO JAKE SONG

IPC: C07D213/75 ,  A61K31/44 ,  A61P7/00

公开(公告)号：HK1217657A1

公开(公告)日：2017-01-20

申请号：HK16105784

申请日：2016-05-20

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA ,  KARBARZ MARK ,  PANDEY ANJALI ,  CONLEY PAMELA B

IPC: A61K20060101 ,  C07K20060101 ,  C12N20060101

公开(公告)号：LT2321283T

公开(公告)日：2016-12-12

申请号：LT09755219

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：HK1213252A1

公开(公告)日：2016-06-30

申请号：HK16101133

申请日：2016-02-01

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  SONG YONGHONG ,  XU QING

IPC: C07D20060101

公开(公告)号：HK1209760A1

公开(公告)日：2016-04-08

申请号：HK15110322

申请日：2015-10-20

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

IPC: C07K20060101 ,  C12N20060101

Abstract: Disclosed herein are methods and kits for purifying a serine protease. The methods entail loading the serine protease to a soybean trypsin inhibitor (STI) based affinity chromatograph, and eluting the serine protease with an elution buffer comprising an agent that disrupts interaction between the STI and the serine protease.

公开(公告)号：NZ625114A

公开(公告)日：2016-02-26

申请号：NZ62511412

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M

IPC: A61K31/4965 ,  C07D241/20 ,  C07D241/28

Abstract: Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：HK1205188A1

公开(公告)日：2015-12-11

申请号：HK15105733

申请日：2015-06-16

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  CONLEY PAMELA B ,  SINHA UMA

IPC: C12N20060101

Abstract: Disclosed are methods and isolated cells useful for the improved production of function fXa derivative protein that acts as a fXa inhibitor antidote. One aspect relates to an isolated cell comprising the r-Antidote polynucleotide and Furin polynucleotide. Another aspect relates to a method for preparing the cleaved two-chain r-Antidote by expressing, in a cell, the pre-processed r-Antidote polypeptide and a Furin polypeptide.

公开(公告)号：HK1201460A1

公开(公告)日：2015-09-04

申请号：HK15102026

申请日：2015-02-28

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K20060101

公开(公告)号：AU2011295909B2

公开(公告)日：2015-05-21

申请号：AU2011295909

申请日：2011-08-31

Applicant: PORTOLA PHARM INC

Inventor： CAPODANNO VINCENT R ,  CORCORAN LIAM ,  MCNEVIN MICHAEL ,  ARROYO ITZIA ZORAIDA ,  WENSLOW ROBERT M ,  BALL RICHARD G ,  MARGELEFSKY ERIC L ,  MAHER TIMOTHY K ,  PANDEY ANJALI

IPC: C07D213/75 ,  A61K31/44 ,  A61P7/02

Abstract: Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.