公开(公告)号：KR1020150076826A

公开(公告)日：2015-07-07

申请号：KR1020130165453

申请日：2013-12-27

Applicant: 한국화학연구원

Inventor： 임희종 ,  이계형 ,  박우규 ,  조희영

IPC: C07D207/10 ,  A61K31/4015 ,  A61P25/00

Abstract: 본발명은하기화학식 1로표시되는 4-(아릴유레이도)피롤리딘유도체또는이의약제학적으로허용가능한염, 이를유효성분으로함유하는신경퇴행성질환의예방및 치료용약제학적조성물및 이를유효성분으로함유하는베타-세크리테아제(BACE)의활성억제제조성물에관한것이다. [화학식 1]본발명에따른 4-(아릴유레이도)피롤리딘유도체는베타-세크리테아제(BACE)의활성을억제하여신경세포를손상시키는베타-아밀로이드단백질의생성을억제함으로써알츠하이머, 다운증후군등의신경퇴행성질환을치료하거나예방하는데효과적으로사용될수 있다.

Abstract translation: 本发明涉及抑制β-分泌酶活性的化学式1表示的4-（芳基脲基）吡咯烷衍生物或其药学上可接受的盐，用于预防和治疗包括其作为活性成分和组成的神经变性疾病的药物组合物 用于抑制β-分泌酶活性（BACE），其包括与活性成分相同的活性成分，其中允许4-（芳基脲基）吡咯烷衍生物抑制β-分泌酶活性（BACE），因此抑制β-淀粉样蛋白的损伤 神经细胞，从而用于治疗或预防神经变性疾病如阿尔茨海默氏病和唐氏综合症。

公开(公告)号：KR101308544B1

公开(公告)日：2013-09-23

申请号：KR1020110059223

申请日：2011-06-17

Applicant: 한국화학연구원

Inventor： 김진수 ,  이미혜 ,  김희주 ,  가재원 ,  이계형

IPC: C07C69/773 ,  C07C69/604 ,  C07D309/12 ,  C09K19/34

Abstract: 본 발명은 하기 화학식 1로 표시되는 화합물 및 이의 제조 방법에 관한 것이다. 본 발명에 따른 상기 화합물은 복굴절 0.1 내지 0.15의 값을 가지고 투명하며 유기 용매에 대한 용해도가 우수하고 다른 중합성 물질과의 상용성 또한 우수하므로 중합성 액정 조성물 성분으로 유용하게 사용될 수 있고, 상기 액정 조성물을 사용하여 제조한 고분자 필름은 광학 이방 특성 및 좋은 내후성을 가지므로 액정 디스플레이용 광학 필름 부재로 유용하게 사용될 수 있다:
[화학식 1]

(상기 화학식 1에서,
Ar, A, R, X, Y 및 n은 본 명세서에서 기재한 바와 같다.).

公开(公告)号：KR1020120139428A

公开(公告)日：2012-12-27

申请号：KR1020110059223

申请日：2011-06-17

Applicant: 한국화학연구원

Inventor： 김진수 ,  이미혜 ,  김희주 ,  가재원 ,  이계형

IPC: C07C69/773 ,  C07C69/604 ,  C07D309/12 ,  C09K19/34

Abstract: PURPOSE: A polymerizable mesogen or a liquid crystal compound capable of providing polymer film with excellent weather resistance and a manufacturing method thereof are provided to enhance compaticility with other polymerizable compound. CONSTITUTION: A compound is represented by chemical formula 1. A manufacturing method of the compound comprises the following steps: manufacturing a compound of chemical formula 4 by reacting with a compound of chemical formula 3; manufacturing a compound of chemical formula 5 with the compound of chemical formula 4; and manufacturing the compound of the chemical formula 1 by reacting the compound of chemical formula 5 with a compound of chemical formula 6. [Reference numerals] (AA) Step 1; (BB) Step 2; (CC) Step 3

Abstract translation: 目的：提供能够提供耐候性优异的聚合物膜的可聚合介晶或液晶化合物及其制造方法，以提高与其它可聚合化合物的可比性。 化合物由化学式1表示。化合物的制造方法包括以下步骤：通过与化学式3的化合物反应制备化学式4的化合物; 用化学式4的化合物制造化学式5的化合物; 通过使化学式5的化合物与化学式6的化合物反应来制造化学式1的化合物。[符号]（AA）步骤1; （BB）步骤2; （CC）步骤3

公开(公告)号：KR101208437B1

公开(公告)日：2012-12-05

申请号：KR1020110086218

申请日：2011-08-29

Applicant: 한국화학연구원

Inventor： 가재원 ,  이미혜 ,  이계형 ,  김진수

IPC: C07D207/452 ,  C07D207/444 ,  C08G73/10

Abstract: PURPOSE: A method for preparing novel photocured polyimide resin is provided to ensure excellent drug resistance, heat resistance, and mechanical property. CONSTITUTION: An aromatic diamine derivative is denoted by chemical formula 1. A method for preparing the aromatic diamine derivative comprises: a step of protecting an amine group of 3,5-dinitrophenyl amine with a carbazole group; a step of reducing a nitro group with an amine group; a step of protecting the amine group; a step of deprotecting the carbazole group; and a step of reacting the deprotected amine group with succinic anhydride derivatives to form a maleimide group.

Abstract translation: 目的：提供一种制备新型光固化聚酰亚胺树脂的方法，以确保优异的耐药性，耐热性和机械性能。 组成：芳族二胺衍生物由化学式1表示。一种制备芳族二胺衍生物的方法包括：用咔唑基保护3,5-二硝基苯胺胺基的步骤; 用胺基还原硝基的步骤; 保护胺基的步骤; 使咔唑组脱保护的步骤; 和使脱保护的胺基与琥珀酸酐衍生物反应形成马来酰亚胺基团的步骤。

公开(公告)号：KR1020120096919A

公开(公告)日：2012-08-31

申请号：KR1020120090882

申请日：2012-08-20

Applicant: 한국화학연구원

Inventor： 가재원 ,  이미혜 ,  정혜인 ,  김진수 ,  이계형

IPC: C07C43/225 ,  C07C69/76 ,  C09K19/32 ,  G02F1/13

Abstract: PURPOSE: A halogen-containing triphenylene based mesogen compound is provided to manufacture a reinforcing film to a thin film because birefringence of high to obtain wide sight angle of a large screen of a liquid crystal display device. CONSTITUTION: A halogen-containing triphenylene based mesogen compound is in chemical formula 1. In chemical formula 1, X is one selected from bromine, chlorine, and iodine, Y is one selected from O, NH, and S, and L is selected from -R-, -C(=O)-R-, -C(=O)-Ar-O-R- and C(=O)-Ar-NH-R-. In here, R is a linear or branched C1-20 alkylene group, Ar is a C6-30 arylene group, and Z is one selected from -OCOCHCH2, -OCOC(CH3)CH2, -OCOCHCH-phenyl, -OCOCHCH-furanyl, -NHCOCHCH2, -NHCOC(CH3)CH2, -NHCOCHCH-phenyl, and -NHCOCHCH-furanyl.

Abstract translation: 目的：提供含卤素的亚苯基系液晶元素化合物，以制造薄膜，因为双折射高，以获得液晶显示装置的大屏幕的宽视角。 构成：含卤素的亚苯基的介晶化合物为化学式1.在化学式1中，X为选自溴，氯和碘的一种，Y为选自O，NH和S的一种，L选自 -R - ， - C（= O）-R - ， - C（= O）-Ar-OR-和C（= O）-Ar-NH-R-。 在这里，R为直链或支链C 1-20亚烷基，Ar为C 6-30亚芳基，Z为选自-OCOCHCH2，-OCOC（CH3）CH2，-OCOCHCH-苯基，-OCOCHCH-呋喃基， -NHCOCHCH 2，-NHCOC（CH 3）CH 2，-NHCOCHCH-苯基和-NHCOCHCH-呋喃基。

公开(公告)号：KR101006145B1

公开(公告)日：2011-01-07

申请号：KR1020080037896

申请日：2008-04-23

Applicant: 한국화학연구원

Inventor： 이미혜 ,  가재원 ,  안택 ,  김진수 ,  이계형

IPC: C09K19/12

CPC classification number: C09K19/32 ,  C09K2019/0429 ,  C09K2019/328

Abstract: 본 발명은 광개시제 없이 광가교에 의해 필름형성이 가능한 광반응성기를 갖는 메조겐 화합물의 합성에 관한 것으로서, 보다 상세하게는 트리페닐렌 중심에 액정상 온도 범위 조절을 위해 곁가지로 다양한 길이의 알킬과 폴리에틸렌클리콜, 페닐 알킬 에스테르, 페닐 폴리에틸렌글리콜 에스테르 사슬이 있고, 다양한 파장에서의 광가교를 위해 곁가지의 말단에 페닐아크릴로일기(신나모일기), 나프틸아크릴로일기과 비페닐아크릴로일기를 갖는 원반상형 액정화합물의 합성에 관한 것이다.
액정 표시장치, 보상필름, 트리페닐렌, 액정, 반응성 메조겐, 원반상형 액정

公开(公告)号：KR1020090005842A

公开(公告)日：2009-01-14

申请号：KR1020070069210

申请日：2007-07-10

Applicant: 한국화학연구원

Inventor： 전동주 ,  노재성 ,  송종환 ,  이계형 ,  김익연 ,  김순기 ,  강남숙 ,  천혜경 ,  조영식 ,  송진숙 ,  민용기 ,  김성환

IPC: C07D231/04 ,  A61K31/415 ,  A61P19/04

Abstract: A novel carbonitrile compound or its pharmaceutically acceptable salt, a method for preparing the compound, and a pharmaceutical composition containing compound are provided to prevent and treat osteoarthritis and various cancer without side effect. A carbonitrile compound is represented by the formula 1, wherein n is 1 or 2; R1 is H, halogen-substituted or unsubstituted linear or branched saturated or unsaturated C1-C10 alkyl, C3-C7 cycloalkyl, C1-C10 alkoxy, C1-C10 alkylthio, hydroxy-C1-C10 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkylthio-C1-C10 alkyl, C3-C7 cycloalkyl-C1-C10 alkyl, C3-C7 cycloalkyl-C1-C10 alkyl, C1-C10 alkoxy-C1-C10 alkyl, phenyl, ar-C1-C10 alkyl, or ar-C1-C10 alkoxy group; and R2 linear or branched saturated or unsaturated C1-C10 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C10 alkyl, phenyl, ar-C1-C10 alkyl, C1-C10 alkoxycarbonyl, or ar-C1-C10 alkoxycarbonyl group.

Abstract translation: 提供新的腈化合物或其药学上可接受的盐，制备该化合物的方法和含有药物组合物的化合物以预防和治疗骨关节炎和各种癌症而没有副作用。 腈化合物由式1表示，其中n为1或2; R1是H，卤素取代或未取代的直链或支链饱和或不饱和C 1 -C 10烷基，C 3 -C 7环烷基，C 1 -C 10烷氧基，C 1 -C 10烷硫基，羟基-C 1 -C 10烷基，C 1 -C 10烷基羰基，C 1 -C 10 烷硫基-C 1 -C 10烷基，C 3 -C 7环烷基-C 1 -C 10烷基，C 3 -C 7环烷基-C 1 -C 10烷基，C 1 -C 10烷氧基-C 1 -C 10烷基，苯基，芳基-C 1 -C 10烷基或芳烷基 -C 10烷氧基 和R 2直链或支链饱和或不饱和的C 1 -C 10烷基，C 3 -C 7环烷基，C 3 -C 7环烷基-C 1 -C 10烷基，苯基，芳基-C 1 -C 10烷基，C 1 -C 10烷氧基羰基或芳基-C 1 -C 10烷氧基羰基 。

公开(公告)号：KR100877394B1

公开(公告)日：2009-01-07

申请号：KR1020070069467

申请日：2007-07-11

Applicant: 한국화학연구원

Inventor： 이계형 ,  전동주 ,  김익연 ,  송종환

IPC: A61K31/415 ,  A61P19/10

CPC classification number: A61K31/415 ,  A61K31/121 ,  A61K31/50

Abstract: A pharmaceutical composition for treating and preventing osteoporosis is provided to improve the selectivity and inhibitory activity to cathepsin K. A pharmaceutical composition for treating and preventing osteoporosis comprises a carbonitrile compound represented by the formula 1, wherein n is 1 or 2; R1 is H, F-substituted or unsubstituted linear or branched saturated or unsaturated C1-C10 alkyl, C3-C7 cycloalkyl, C1-C10 alkoxy, C1-C10 alkylthio, C1-C10 hydroxyalkyl, C1-C10 alkylcarbonyl, C1-C10 alkylthio C1-C10 alkyl, C3-C7 cycloalkyl C1-C10 alkyl, C3-C7 cycloalkyl C1-C10 alkoxy, C1-C10 alkoxy C1-C10 alkyl, phenyl, ar-C1-C10 alkyl, or ar-C1-C10 alkoxy group; and R2 is linear or branched saturated or unsaturated C1-C10 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl C1-C10 alkyl, phenyl, ar-C1-C10 alkyl, C1-C10 alkoxycarbonyl, or ar-C1-C10 alkoxy group.

Abstract translation: 提供了用于治疗和预防骨质疏松症的药物组合物，以提高对组织蛋白酶K的选择性和抑制活性。用于治疗和预防骨质疏松症的药物组合物包括由式1表示的腈化合物，其中n为1或2; R1是H，F-取代或未取代的直链或支链饱和或不饱和的C1-C10烷基，C3-C7环烷基，C1-C10烷氧基，C1-C10烷硫基，C1-C10羟基烷基，C1-C10烷基羰基，C1-C10烷硫基C1 -C 10烷基，C 3 -C 7环烷基C 1 -C 10烷基，C 3 -C 7环烷基C 1 -C 10烷氧基，C 1 -C 10烷氧基C 1 -C 10烷基，苯基，芳基-C 1 -C 10烷基或芳烷基-C 1 -C 10烷氧基; 并且R 2是直链或支链饱和或不饱和的C 1 -C 10烷基，C 3 -C 7环烷基，C 3 -C 7环烷基C 1 -C 10烷基，苯基，芳基-C 1 -C 10烷基，C 1 -C 10烷氧基羰基或芳烷基-C 1 -C 10烷氧基 。

公开(公告)号：KR100833799B1

公开(公告)日：2008-05-30

申请号：KR1020070002725

申请日：2007-01-10

Applicant: 한국화학연구원

Inventor： 전동주 ,  노재성 ,  송종환 ,  이계형 ,  김익연 ,  박창민 ,  소원영 ,  이지선 ,  김은주 ,  강남숙 ,  천혜경 ,  조영식 ,  송진숙 ,  배명애 ,  김지현 ,  조중명 ,  노성구 ,  현영란 ,  이철순 ,  이재일 ,  유성은

IPC: C07D401/06 ,  C07D413/14

Abstract: 1-[1-(3,4-Dialkoxyaryl)-pyridylmethyl]-1H-pyrazole compounds are provided to inhibit activity of PDE-4(phosphodiesterase-4) with high activity and selectivity without side effects, so that the compounds are useful for treating inflammation diseases, neurodegenerative disease and cancers. 1-[1-(3,4-Dialkoxyaryl)-pyridylmethyl]-1H-pyrazole compounds represented by the formula(1) are provided, wherein A is N or CH; R1 is linear or branched, saturated or unsaturated (C1-C7)alkyl or halogen-substituted linear or branched, saturated or unsaturated (C1-C7)alkyl; R2 is hydrogen atom, (C3-C7)cycloalkyl or (C3-C8)cycloalkylmethyl; R3, R4 and R5 are each independently hydrogen atom, phenyl, pyridinyl, N-oxypyridinyl, linear or branched, saturated or unsaturated (C1-C7)alkyl, (C3-C7)cycloalkyl, (C3-C10)cycloalkyl(C1-C7)alkyl, halogen atom, cyano, nitro, amino, mono- or di(C1-C7)alkylamino, mono- or di(C1-C7)alkylaminocarbonyl, (C3-C7)cycloalkylamino, 3- to 7-membered saturated or unsaturated hetero ring containing oxygen, nitrogen or sulfur in hetero ring, guanidinyl, ureido, benzyl, benzyloxy, formyl, (C1-C7)alkanoyl, (C1-C7)alkoxy, (C1-C7)alkoxy(C1-C7)alkyl, hydroxy(C1-C7)alkyl, carboxyl or (C1-C7)alkoxycarbonyl; and R6 is pyridinyl or N-oxypyridinyl group.

Abstract translation: 提供1- [1-（3,4-二烷氧基芳基） - 吡啶基甲基] -1H-吡唑化合物以抑制具有高活性和选择性的PDE-4（磷酸二酯酶-4）的活性而没有副作用，使得该化合物可用于 治疗炎症疾病，神经退行性疾病和癌症。 提供由式（1）表示的1- [1-（3,4-二烷氧基芳基） - 吡啶基甲基] -1H-吡唑化合物，其中A是N或CH; R1是直链或支链饱和或不饱和（C1-C7）烷基或卤素取代的直链或支链饱和或不饱和（C1-C7）烷基; R2是氢原子，（C3-C7）环烷基或（C3-C8）环烷基甲基; R 3，R 4和R 5各自独立地为氢原子，苯基，吡啶基，N-氧代吡啶基，直链或支链，饱和或不饱和的（C1-C7）烷基，（C3-C7）环烷基，（C3-C10）环烷基 ）（C 1 -C 7）烷基氨基羰基，（C 3 -C 7）环烷基氨基，3至7元饱和或不饱和的（C 1 -C 7）烷基氨基， 杂环中含氧，氮或硫的杂环，胍基，脲基，苄基，苄氧基，甲酰基，（C1-C7）烷酰基，（C1-C7）烷氧基，（C1-C7）烷氧基（C1-C7） （C 1 -C 7）烷基，羧基或（C 1 -C 7）烷氧基羰基; R6是吡啶基或N-氧代吡啶基。

公开(公告)号：KR100829468B1

公开(公告)日：2008-05-16

申请号：KR1020070005075

申请日：2007-01-17

Applicant: 한국화학연구원

Inventor： 이계형 ,  원종화 ,  김익연 ,  노재성 ,  김지영 ,  원혜경 ,  정은주 ,  허민규 ,  김성주 ,  김영림 ,  전동주 ,  송종환 ,  강남숙 ,  유성은

IPC: C07D285/08 ,  C07D417/06 ,  A61P3/10 ,  A61P25/28

Abstract: A 1,2,4-thiadiazolidine-3,5-dione compound is provided to be used for synthesizing various 1,2,4-thiadiazolidine-3,5-dione compounds because of substitution of amide at 4-position of a thiadiazolidine-2,5-dione with a thiadiazolidine-3,5-dione as a skeleton. A 1,2,4-thiadiazolidine-3,5-dione compound is represented by a formula(1) and is prepared by hydrolyzing an ester compound represented by a formula(2) to prepare an acetic acid compound represented by a formula(3) and then reacting the compound of the formula(3) with an amine compound represented by a formula(4), wherein R1 is linear or branched saturated or unsaturated C1-7 alkyl, C1-7 alkoxycarbonyl C1-7 alkyl, phenyl, C1-7 alkyl substituted phenyl, benzyl or allyl; R1 and R2 are independent from each other and H, linear or branched saturated or unsaturated C1-7 alkyl, phenyl, halogen substituted phenyl, or R2 and R3 may form a ring, or the ring formed by an alkylene further includes 1-2 heteroatom(s) and may be further substituted by halogen, C1-7 alkyl, hydroxyl or C1-7 alkoxycarbonyl.

Abstract translation: 提供了一种1,2,4-噻二唑烷-3,5-二酮化合物，用于合成各种1,2,4-噻二唑烷-3,5-二酮化合物，因为噻二唑烷-3,4-二酮化合物在4-位取代酰胺， 噻唑烷-3,5-二酮作为骨架。 1,2,4-噻二唑烷-3,5-二酮化合物由式（1）表示，通过水解式（2）表示的酯化合物来制备由式（3）表示的乙酸化合物 ），然后使式（3）的化合物与由式（4）表示的胺化合物反应，其中R 1是直链或支链饱和或不饱和的C 1-7烷基，C 1-7烷氧基羰基C 1-7烷基，苯基，C 1 -7烷基取代的苯基，苄基或烯丙基; R 1和R 2彼此独立，H，直链或支链饱和或不饱和的C 1-7烷基，苯基，卤素取代的苯基或R 2和R 3可以形成环，或由亚烷基形成的环还包括1-2个杂原子 可以进一步被卤素，C 1-7烷基，羟基或C 1-7烷氧基羰基取代。