公开(公告)号：HU178208B

公开(公告)日：1982-03-28

申请号：HUDE000949

申请日：1978-01-11

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D409/06

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：CA1116173A

公开(公告)日：1982-01-12

申请号：CA335022

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/155 ,  A61K31/403 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C129/12 ,  C07D209/20

Abstract: Compounds corresponding to the formula (I) are disclosed, wherein Alk represents a C2-C5-alkylene group which may be substituted by a hydroxy group and Ar represents unsubstituted phenyl, naphthyl or indolyl radical or a phenyl, naphthyl or indolyl radical substituted one or more times by a Cl-C6-alkyl group, a C2-C6-alkenyl group, a Cl-C6-alkoxy group, a C2-C6-alkenoxy group, or a halogen atom and pharmaceutically acceptable acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyi guanidines block the .beta.-receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：RO76053A

公开(公告)日：1981-11-04

申请号：RO9851779

申请日：1979-09-06

Applicant: DEGUSSA

Inventor： KLINGER KARL H ,  KLEEMANN AXEL ,  STREMANN FRITZ ,  THIEMER KLAUS

IPC: A61K31/403 ,  A61K31/155 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C133/10

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：FR2467842A1

公开(公告)日：1981-04-30

申请号：FR8018942

申请日：1980-09-02

Applicant: DEGUSSA

Inventor： SUCHSLAND HELMUT ,  HAFNER VOLKER ,  KLEEMANN AXEL

IPC: C07C253/08 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/24 ,  C07C255/61 ,  C07C121/43 ,  C07C120/00

Abstract: The invention is directed to a process for the production of iminodiacetonitrile by reaction of hexamethylenetetramine with hydrogen cyanide in acidic aqueous mediums. In this process the pH during the reaction which is 5.5 to 7.5 at the beginning is progressively lowered, altogether around 0.5 to 3.5 units and free formaldehyde is present only to a slight extent. Through this and in contrast to the known processes the formation of byproducts is suppressed and iminodiacetonitrile is produced directly in very good yields and sufficiently pure for further use.

公开(公告)号：FR2467190A1

公开(公告)日：1981-04-17

申请号：FR8020394

申请日：1980-09-23

Applicant: DEGUSSA

Inventor： SCHWARZE WERNER ,  KLEEMANN AXEL ,  REMMEL HANS ,  HOHN WOLFGANG

IPC: C07C69/74 ,  B01J31/00 ,  B01J31/02 ,  C07B20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C67/30 ,  C07C67/317

Abstract: gamma -chlorocarboxylic acid methyl or ethyl esters are cyclized to the corresponding cyclopropane carboxylic acid esters by employing the sodium or potassium alcoholate of methanol or ethanol in the presence of the same alcohol at a temperature above the boiling point of the alcohol employed.

公开(公告)号：CA1088941A

公开(公告)日：1980-11-04

申请号：CA286004

申请日：1977-09-01

Applicant: DEGUSSA

Inventor： BESCHKE HELMUT ,  FRIEDRICH HEINZ ,  KLEEMANN AXEL

IPC: C07D221/06 ,  C07D221/16

Abstract: The present invention provides a process for producing 2,3:5,6-bis-cycloalkeno)pyridines from cycloalkanones, in which cycloalkanones having at least one reactive methylene group adjacent to the keto group are reacted with aliphatic aldehydes and with ammonia in the gas phase at temperatures from approximately 250 to 550.degree.C in the presence of a catalyst having dehydrating and dehydrogenating properties.

公开(公告)号：DD142883A5

公开(公告)日：1980-07-16

申请号：DD21212778

申请日：1978-01-10

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D409/06

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：FI792755A

公开(公告)日：1980-03-07

申请号：FI792755

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGER KARL-HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/403 ,  A61K31/155 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：IT7951079D0

公开(公告)日：1979-12-13

申请号：IT5107979

申请日：1979-12-13

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL

IPC: C07C255/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/33 ,  C07D213/57 ,  C07D333/24

公开(公告)号：CA1067061A

公开(公告)日：1979-11-27

申请号：CA239905

申请日：1975-11-18

Applicant: DEGUSSA

Inventor： FRIEDRICH HEINZ ,  HEIM WOLFGANG ,  KLEEMANN AXEL ,  KOLB HEINZ ,  SCHREYER GERD

IPC: C07D301/02 ,  B01J8/18 ,  B01J38/00 ,  C01G31/00 ,  C01G33/00 ,  C01G41/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/03 ,  C07C31/18 ,  C07C67/00 ,  C07D301/12 ,  C07D301/32 ,  C07D303/04 ,  B01J23/16 ,  B01J37/00

Abstract: The present invention provides a process for the separation of a catalyst employed in the epoxidation or hydroxylation of an olefinic compound with a peroxy compound in a reactor, distilling off the epoxidized or hydroxylated product and separation of the catalyst from the distillation residue containing said catalyst and said high boiling organic compounds, said catalyst being a compound of a transition metal, the improvement comprising introducing the distillation residue into a bed of fluidized inert solid particles, burning the organic compounds of said distillation residue with an oxygen containing gas while in contact with said fluidized particles and separating fluidized particles containing a compound of the metal employed in the catalyst from the waste gas of said burning.