公开(公告)号：AU2013201426A1

公开(公告)日：2013-04-04

申请号：AU2013201426

申请日：2013-03-12

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA ,  ROWE WILLIAM ,  YOUNG CHRISTOPHER R ,  COSTACHE ADRIANA ,  CONNELLY PATRICK ,  KRAWIEC MARIUSZ ,  GONG YUCHUAN ,  TRUDEAU MARTIN ,  FENG YUSHI

IPC: A61K31/445

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1 ,1-dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

公开(公告)号：AU2011230508A1

公开(公告)日：2012-10-18

申请号：AU2011230508

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/404 ,  A61P11/00

Abstract: The present invention relates to solid forms of ()-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2- methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：CA2796642A1

公开(公告)日：2011-10-27

申请号：CA2796642

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  AREKAR SNEHA G ,  JOHNSTON STEVEN C ,  KADIYALA IRINA NIKOLAEVNA ,  KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  LEE ELAINE CHUNGMIN ,  MEDEK ALES ,  MUDUNURI PRAVEEN ,  SULLIVAN MARK JEFFREY ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：CA2795748A1

公开(公告)日：2011-10-13

申请号：CA2795748

申请日：2011-04-07

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  C07D213/75 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention relates to a substantially a solid form of 3-(6-(l-(2,2- difluorobenzo[d][l,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1, Solvate Form A and Compound 1, HCl Salt Form A), processes for making such forms, pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：MX2010006179A

公开(公告)日：2010-08-04

申请号：MX2010006179

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZSHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/443 ,  A61P11/00

Abstract: La presente invención se relaciona con una forma de estado sólido sustancialmente libre y cristalina del ácido 3-(6-(1-(2,2-difluoro benzo [D] [1,3] DIOXOL-5-il) ciclopropancarboxamido) -3-metilpiridin-2-il) benzoico (Forma I) de la siguiente fórmula: (I), sus composiciones farmacéuticas y métodos para el tratamiento con las mismas. (ver fórmula anexa).

公开(公告)号：CY1122861T1

公开(公告)日：2021-05-05

申请号：CY201100244

申请日：2020-03-17

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA ,  GONG YUCHUAN ,  YOUNG CHRISTOPHER R ,  CONNELLY PATRICK ,  ROWE WILLIAM ,  COSTACHE ADRIANA ,  KRAWIEC MARIUSZ ,  FENG YUSHI ,  TRUDEAU MARTIN

IPC: C07D215/56 ,  A61K31/445

Abstract: ΗπαρούσαεφεύρεσηαφοράσεστερεάςκατάστασηςμορφέςτουΝ-[2,4-δις(1,1-διμεθυλαιθυλ)-5-υδροξυφαινυλ]-1,4-διυδρο-4-οξοκινολινο-3-καρβοξαμιδίου (Ένωση 1), φαρμακευτικέςσυνθέσειςαυτούκαιμεθόδουςμεαυτό.

公开(公告)号：HRP20210165T1

公开(公告)日：2021-03-19

申请号：HRP20210165

申请日：2021-02-01

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ

IPC: A61K9/10 ,  A61K31/404 ,  A61P11/00 ,  C07D405/12

公开(公告)号：SI2826776T1

公开(公告)日：2021-02-26

申请号：SI201131935

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ

IPC: A61K9/00 ,  A61K31/00 ,  A61P11/00 ,  C07D405/00

公开(公告)号：PL3219705T3

公开(公告)日：2020-08-10

申请号：PL17154944

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： KRAWIEC MARIUSZ ,  FENG YUSHI ,  TRUDEAU MARTIN ,  HURTER PATRICIA ,  GONG YUCHUAN ,  YOUNG CHRISTOPHER R ,  CONNELLY PATRICK ,  ROWE WILLIAM ,  COSTACHE ADRIANA

IPC: C07D215/56 ,  A61K31/445

公开(公告)号：LT3170818T

公开(公告)日：2020-05-25

申请号：LT16198922

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/4709 ,  A61P11/00