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    79.
    发明专利
    未知

    公开(公告)号：AT239227T

    公开(公告)日：2003-05-15

    申请号：AT98949736

    申请日：1998-10-02

    Applicant: SYMYX TECHNOLOGIES INC

    Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  MCFARLAND ERIC

    IPC: G01H13/00 ,  G01N5/04 ,  G01N9/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  H03H9/19

    Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.

    Polymer brushes for immobilizing molecules to a surface
    80.
    发明专利
    Polymer brushes for immobilizing molecules to a surface 未知

    公开(公告)号：AU2002246978A1

    公开(公告)日：2002-07-24

    申请号：AU2002246978

    申请日：2002-01-10

    Applicant: SYMYX TECHNOLOGIES INC

    Inventor： CHARMOT DOMINIQUE ,  KLAERNER GERRIT ,  PIOTTI MARCELO E ,  BENOIT DIDIER ,  NOMULA SRINIVAS ,  MAZZOLA LAURA T

    IPC: C08F293/00 ,  G01N33/543 ,  C08F220/00 ,  G01N33/545 ,  C08J7/16

    Abstract: Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

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