公开(公告)号：SK76997A3

公开(公告)日：1998-02-04

申请号：SK76997

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: The present invention concerns a method of producing divisible tablets by melting the mixture containing one or more pharmaceutically active substances and one or more additive substances; and by calendering the melting with two rotating form cylinders with the cavities for suppression and forming the melting to the tablets. Device for suppression and forming of the melting to the tablets comprises at least one form cylinder (6, 8) with cavities (2) divided by at least one ridge (7) which extends as far as the surface line of the cylinder and forms a break groove.

公开(公告)号：MX9706652A

公开(公告)日：1997-11-29

申请号：MX9706652

申请日：1996-03-09

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30 ,  A61K09/00 ,  A61K09/20

Abstract: La presente invencion se refiere a las composiciones transparentes para sustancia activas de liberacion rápida obtenibles por extrusion de masas fundidas, que contienen analgésicos no esteroidales, homopolímeros de N-vinilpirrolidona, sacáridos o alcoholes grasos y sales de sodio o de potasio.

公开(公告)号：MX9704625A

公开(公告)日：1997-09-30

申请号：MX9704625

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16 ,  A61J03/10 ,  A61K09/20

Abstract: La presente invencion se refiere a un proceso para la produccion de tabletas divisibles mediante calandrado por fusion en el que 2 rodillos de moldeo se combinan juntos, por lo menos uno de los cuales tiene depresiones con por lo menos una barra que se extiende hasta la línea superficial del rodillo de moldeo y forma un registro.

公开(公告)号：AU1541697A

公开(公告)日：1997-08-20

申请号：AU1541697

申请日：1997-01-17

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  ROSENBERG JOERG

IPC: A61K47/04 ,  A61K9/20 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture ofa) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30,b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, andc) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium,where the stated amounts are based on the total of components a), b) and c).

公开(公告)号：AU7491296A

公开(公告)日：1997-05-15

申请号：AU7491296

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  HARTL AXEL PAUL ,  HOFMANN JURGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：CA2368625C

公开(公告)日：2008-11-18

申请号：CA2368625

申请日：2000-03-17

Applicant: BASF AG

Inventor： SACK HEINRICH ,  RUCHATZ FOLKER ,  SANNER AXEL ,  BREITENBACH JORG ,  BERNDL GUNTHER

IPC: A61K9/20 ,  A61K47/14 ,  A61K9/14 ,  A61K47/32 ,  A61K47/44

Abstract: The invention relates to additives in powder form for use in solid pharmaceutical presentation forms. Said aids contain a pharmaceutically acceptable polymer and a liquid or semi-solid surface-activ e substance with solubilizing action.

公开(公告)号：CA2190882C

公开(公告)日：2007-01-16

申请号：CA2190882

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/20 ,  A61K9/14 ,  A61K31/19 ,  B01J2/20

Abstract: A process for producing active agent preparations in the form of a solid sol ution of the active agent in a polymer matrix in which the active agent is melt-extruded in non-ionic form together with a polymer and a salt.

公开(公告)号：CA2208541C

公开(公告)日：2006-03-28

申请号：CA2208541

申请日：1995-12-22

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  GRABOWSKI SVEN ,  ROSENBERG JOERG ,  MAIER WERNER

IPC: A61J3/10 ,  A61J1/03 ,  A61J3/00 ,  A61K9/20 ,  B30B11/16 ,  B65B9/04

Abstract: The invention concerns a method of producing coated tablets by melt calendering, the melt containing the active substance being introduced into the forth cylinders between two films of the coating material.

公开(公告)号：CA2286832C

公开(公告)日：2006-03-07

申请号：CA2286832

申请日：1998-05-13

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  ZETTLER HANS DIETER

IPC: B01J2/20 ,  A61K9/16 ,  B29C47/00 ,  B29C47/40 ,  B29C47/78 ,  B29C48/395 ,  B29C48/67

Abstract: The invention relates to a method for the continuous production of solid, particle-based preparations of biologically active substances, in which preparations the biologically active substances are homogeneously distributed in a matrix of additives which can be thermoplastically processed, in a screw extruder divided into several zones. Said method is characterized in that the matrix additives are first melted in a healable area and the biologically active components mixed with the matrix additives. Thereafter, the mixture is cooled, pre-crushed and finely ground in a cooling zone. The screw geometry of the cooling zone is designed in such a way that the cooling zone comprises a conveyor zone, a mixing zone and a kneading zone.

公开(公告)号：ES2180738T3

公开(公告)日：2003-02-16

申请号：ES96903958

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JORG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.