公开(公告)号：CA2439684A1

公开(公告)日：2002-09-12

申请号：CA2439684

申请日：2002-02-28

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  ZELDER OSKAR ,  POMPEJUS MARKUS ,  KROGER BURKHARD

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/10 ,  C12N15/54 ,  C12N15/77 ,  C12R1/13 ,  C12N15/90

Abstract: The invention relates to a novel method of modifying the genome of gram- positive bacteria, to said bacteria and to novel vectors. The invention especially relates to a method of modifying Corynebacteria or Brevibacteria using a novel marker gene that has a conditionally negative dominant effect.

公开(公告)号：AU2930099A

公开(公告)日：1999-09-27

申请号：AU2930099

申请日：1999-02-26

Applicant: BASF AG

Inventor： KROGER BURKHARD

IPC: A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  A01K67/027 ,  C07K16/28 ,  C12N15/11 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/68

公开(公告)号：BR9507231A

公开(公告)日：1997-09-16

申请号：BR9507231

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  REICHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：NZ283333A

公开(公告)日：1997-02-24

申请号：NZ28333395

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  C07D251/26 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D239/00 ,  C07D251/00

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：NZ275817A

公开(公告)日：1997-02-24

申请号：NZ27581794

申请日：1994-11-10

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  SEULBERGER HARALD ,  MEYER THOMAS ,  SCHMIDT MARTIN ,  JACOB ELARD ,  OTTER RAINER ,  SUBKOWSKI THOMAS ,  HILLEN HEINZ

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91 ,  C12N9/14 ,  C12N15/55 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/37

Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.

公开(公告)号：NO964121A

公开(公告)日：1996-11-26

申请号：NO964121

申请日：1996-09-27

Applicant: BASF AG

Inventor： BAUMANN ERNST ,  VOGELBACHER UWE JOSEF ,  RHEINHEIMER JOACHIM ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  KROGER BURKHARD ,  BIALOJAN SIEGFRIED ,  BOLLSCHWEILER CLAUS ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D251/26 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/53

公开(公告)号：CA2402186C

公开(公告)日：2011-04-05

申请号：CA2402186

申请日：2000-12-22

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  KIM JUN-WON ,  LEE HEUNG-SHICK ,  HWANG BYUNG-JOON

IPC: C12N15/09 ,  C12N15/54 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/21 ,  C12N9/90 ,  C12P20060101 ,  C12P13/08 ,  C12P13/12 ,  C12P21/02 ,  C12R1/13

Abstract: Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins form Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism.

公开(公告)号：CA2330206C

公开(公告)日：2010-04-13

申请号：CA2330206

申请日：1999-06-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOGER THOMAS ,  KROGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS-GEORG

IPC: A01K67/027 ,  C12N15/54 ,  A61K31/70 ,  A61K38/00 ,  A61K38/45 ,  A61K39/395 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/10 ,  C12N15/63 ,  C12Q1/48 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/566

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologues which are characterised by an amino acid sequence with a) a functional NAD+ -binding site and b) no zinc-finger-sequence motif of general formula CX2CX m HX2C, wherein m is an integral number 28 or 30 and the radicals X represent any amino acid, independently of each other, and to the functional equivalents of said poly(ADP-ribose)polymerase (PARP) homologues. The invention also relates to nucleic acids coding the poly(ADP-ribose)polymerase (PARP) homologues, to antibodies with specificity for the novel protein, to pharmaceutical and gene therapy agents containing the inventive products, to methods for analytically determining the inventive proteins and nucleic acids, to methods for identifying the effectors or bonding partners of the inventive proteins, to novel PARP effectors and to methods for determining the effectiveness of effectors of this type.

公开(公告)号：ZA200605866B

公开(公告)日：2008-06-25

申请号：ZA200605866

申请日：2006-07-17

Applicant: BASF AG

Inventor： KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  HAEFNER STEFAN ,  RUFFER UWE ,  GRAEF CLAUDIA ISABELLA ,  HABERHAUER GREGOR

IPC: C07K20090101 ,  C07K14/34

Abstract: The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.

公开(公告)号：TR200700070T2

公开(公告)日：2008-06-23

申请号：TR200700070

申请日：2000-06-27

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  HARBERHAUER GREGOR ,  ZELDER OSKAR ,  SCHRODER HARTWIG

IPC: C12N9/00 ,  G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569