公开(公告)号：HK1028023A1

公开(公告)日：2001-02-02

申请号：HK00107516

申请日：2000-11-23

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F JR ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07C

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：TR9903287T2

公开(公告)日：2000-09-21

申请号：TR9903287

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F JR ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/16 ,  A61K31/415

CPC classification number: C07D207/404 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C323/47 ,  C07C323/62 ,  C07D207/408 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

公开(公告)号：PL337854A1

公开(公告)日：2000-09-11

申请号：PL33785498

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F JR ,  FLORJANCIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN H ROBIN ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: C07D233/74 ,  A61K31/275 ,  A61K31/351 ,  A61K31/352 ,  A61K31/4035 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4465 ,  A61K31/45 ,  A61K31/454 ,  A61K31/50 ,  A61P1/02 ,  A61P1/04 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C259/06 ,  C07C311/05 ,  C07C311/18 ,  C07C317/28 ,  C07C317/40 ,  C07C323/47 ,  C07C323/62 ,  C07D207/40 ,  C07D207/404 ,  C07D207/416 ,  C07D209/48 ,  C07D211/88 ,  C07D213/68 ,  C07D233/76 ,  C07D233/78 ,  C07D237/14 ,  C07D263/44 ,  C07D275/04 ,  C07D275/06 ,  C07D309/14 ,  C07D311/18 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/16

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

公开(公告)号：CZ9904730A3

公开(公告)日：2000-06-14

申请号：CZ473099

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DELLARIA JOSEPH F JR ,  FLORJANIC ALAN S ,  GIESLER JAMIE ,  GONG JIANCHUN ,  GUO YAN ,  HEYMAN ROBIN H ,  HOLMS JAMES H ,  MICHAELIDES MICHAEL R ,  STEINMAN DOUGLAS H ,  WADA CAROL K ,  XU LIANHONG

IPC: A61K31/16 ,  A61P19/02 ,  A61P35/00 ,  C07C259/00 ,  C07C259/04

公开(公告)号：CA2672868C

公开(公告)日：2015-11-24

申请号：CA2672868

申请日：2007-12-20

Applicant: ABBOTT LAB

Inventor： GANDHI VIRAJ B ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  PENNING THOMAS D ,  ZHU GUI-DONG

IPC: C07D403/10 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/55 ,  A61P35/00 ,  C07D237/32 ,  C07D401/10 ,  C07D471/04

Abstract: The present invention relates to compounds of formula (Ik) or pharmaceutical acceptable salts, (see formula Ik) wherein R101, R102, R103, R104, and R105 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting poly(ADP-ribose)polymerase (PARP).

公开(公告)号：CA2641776C

公开(公告)日：2014-04-08

申请号：CA2641776

申请日：2007-02-15

Applicant: ABBOTT LAB

Inventor： PENNING THOMAS D ,  ZHU GUI-DONG ,  GANDHI VIRAJKUMAR B ,  GONG JIANCHUN ,  GIRANDA VINCENT L

IPC: C07D471/04 ,  A61K31/438 ,  A61P35/00 ,  C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

公开(公告)号：CA2647373C

公开(公告)日：2014-03-18

申请号：CA2647373

申请日：2007-05-02

Applicant: ABBOTT LAB

Inventor： GIRANDA VINCENT L ,  PENNING THOMAS D ,  GANDHI VIRAJKUMAR B ,  THOMAS SHEELA A ,  ZHU GUI-DONG ,  GONG JIANCHUN

IPC: C07D403/10

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

公开(公告)号：RS52990B

公开(公告)日：2014-02-28

申请号：RSP20130428

申请日：2006-04-11

Applicant: ABBOTT LAB

Inventor： GANDHI VIRAJKUMAR B ,  ZHU GUIDONG ,  GONG JIANCHUN ,  PENNING THOMAS D ,  GIRANDA VINCENT

IPC: A61K31/4184 ,  A61K31/454 ,  A61K31/55 ,  A61P9/10

Abstract: Compounds of Formula (I) (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

公开(公告)号：PL2420234T3

公开(公告)日：2013-12-31

申请号：PL11189346

申请日：2006-04-11

Applicant: ABBOTT LAB

Inventor： ZHU GUIDONG ,  GONG JIANCHUN ,  GANDHI VIRAJKUMAR B ,  PENNING THOMAS D ,  GIRANDA VINCENT

IPC: A61K31/4184 ,  A61K31/454 ,  A61K31/55 ,  A61P9/10

公开(公告)号：CA2623822C

公开(公告)日：2013-11-12

申请号：CA2623822

申请日：2006-09-28

Applicant: ABBOTT LAB

Inventor： PENNING THOMAS D ,  THOMAS SHEELA A ,  ZHU GUI-DONG ,  GANDHI VIRAJKUMAR B ,  GONG JIANCHUN ,  GIRANDA VINCENT L

IPC: C07D401/10 ,  A61K31/4178 ,  A61K31/454 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  C07D403/10

Abstract: Compounds having formula (I) (see formula I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds haying formula (I).