中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

319 records (took 0.023 seconds)

    Preparation of optically active alkanol compound, useful for the treatment of depression or incontinence, comprises incubating an enzyme with a polypeptide sequence in a medium containing alkanone compound and isolating
    82.
    发明专利
    Preparation of optically active alkanol compound, useful for the treatment of depression or incontinence, comprises incubating an enzyme with a polypeptide sequence in a medium containing alkanone compound and isolating 未知

    公开(公告)号：DE102005062662A1

    公开(公告)日：2007-06-28

    申请号：DE102005062662

    申请日：2005-12-23

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  KESELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

    IPC: C12N9/04 ,  C12P7/02

    Abstract: Preparation of optically active alkanol compound (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound (II) and isolating the product, where (II) is enzymatically reduced to (I). Preparation of optically active alkanol compound of formula (I) comprises incubating an enzyme with a polypeptide sequence of SEQ ID NO:1 (Not defined) or the SEQ ID NO:1 with up to 25% of amino acids modified by deletion, insertion and/or substitution and at least 50% of which possess enzymatic activity, in a medium containing alkanone compound of formula Cyc-(C=O)-(CH 2) n-CH 2-R 1>(II) and isolating the product, where (II) is enzymatically reduced to (I). n : 0-5; Cyc : optionally substituted, mono- or polynuclear, (un)saturated, carbocylic or heterocyclic ring; R 1>halo, SH, OH, NO 2, NR 2>R 3> or NR 2>R 3>R 4+>X ->; R 2>-R 4>H, lower alkyl or lower alkoxy; and X ->counter ion. An independent claim is also included for the enzyme with dehydrogenase activity. [Image] ACTIVITY : Antidepressant; Uropathic. No biological data given. MECHANISM OF ACTION : None given.

    85.
    发明专利
    未知

    公开(公告)号：DK1123386T3

    公开(公告)日：2007-05-07

    申请号：DK99952558

    申请日：1999-10-13

    Applicant: BASF AG

    Inventor： MATTES RALF ,  HAUER BERNHARD ,  RESS-LOESCHKE MARION ,  FRIEDRICH THOMAS ,  ENGELS DIRK

    IPC: C12N9/78 ,  C12N15/09 ,  C07H21/00 ,  C12N1/21 ,  C12N15/55 ,  C12N15/63 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05

    Abstract: The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs.The invention additionally relates to a process for preparing chiral carboxylic acids from the racemic nitriles.

Patent Agency Ranking