公开(公告)号：AU2020277027A1

公开(公告)日：2021-12-09

申请号：AU2020277027

申请日：2020-05-12

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  AMEDZO LUKIANA ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  KARP GARY MITCHELL ,  KENTON NATHANIEL T ,  LUONG TOM TUAN ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  MORRILL CHRISTIE ,  MSZAR NICHOLAS WALTER ,  NARASIMHAN JANA ,  PATEL JIGAR S ,  REN HONGYU ,  TURPOFF ANTHONY ,  WANG GANG ,  WOLL MATTHEW G ,  ZHANG NANJING ,  ZHANG XIAOYAN

IPC: C07D401/14 ,  A61K31/501 ,  A61K31/53 ,  A61P25/28 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), Formula (II), or Formula (III), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：MX2020014098A

公开(公告)日：2021-05-27

申请号：MX2020014098

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： GERASYUTO ALEKSEY I ,  WOLL MATTHEW G ,  CHEN GUANGMING ,  NARASIMHAN JANA ,  ZHANG NANJING ,  KARP GARY MITCHELL ,  SYDORENKO NADIYA ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  MAZZOTTI ANTHONY R ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  MOON YOUNG-CHOON ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  KASSICK ANDREW J ,  YAN WUMING

IPC: A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: La presente descripción se refiere a compuestos, formas y composiciones farmacéuticas de los mismos y a métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington. En particular, la presente descripción se refiere a compuestos heterocíclicos y de heteroarilo sustituidos de Fórmula (I), formas y composiciones farmacéuticas de los mismos y a métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington.

公开(公告)号：CA2863874C

公开(公告)日：2021-02-16

申请号：CA2863874

申请日：2013-02-08

Applicant: PTC THERAPEUTICS INC ,  HOFFMANN LA ROCHE

Inventor： QI HONGYAN ,  CHOI SOONGYU ,  DAKKA AMAL ,  KARP GARY MITCHELL ,  NARASIMHAN JANA ,  NARYSHKIN NIKOLAI ,  TURPOFF ANTHONY A ,  WEETALL MARIA L ,  WELCH ELLEN ,  WOLL MATTHEW G ,  YANG TIANLE ,  ZHANG NANJING ,  ZHANG XIAOYAN ,  ZHAO XIN ,  GREEN LUKE ,  PINARD EMMANUEL ,  RATNI HASANE

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/551 ,  A61P21/00 ,  A61P25/28 ,  C07D455/02 ,  C07D471/04 ,  C07D487/02

Abstract: Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.

公开(公告)号：SG11202012674PA

公开(公告)日：2021-01-28

申请号：SG11202012674P

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：AU2019294482A1

公开(公告)日：2021-01-21

申请号：AU2019294482

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I) or (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：AU2019294478A1

公开(公告)日：2021-01-21

申请号：AU2019294478

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. Formula (I). In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：CL2019003798A1

公开(公告)日：2020-07-17

申请号：CL2019003798

申请日：2019-12-20

Applicant: PTC THERAPEUTICS INC

Inventor： BHATTACHARYYA ANURADHA ,  JANI MINAKSHI B ,  SYDORENKO NADIYA ,  WOLL MATTHEW G

IPC: A61K31/4353 ,  A61K31/4375 ,  A61K31/4545 ,  C07D401/00 ,  C07D401/14

Abstract: LA PRESENTE DESCRIPCIÓN SE REFIERE A UN MÉTODO O USO DE UN COMPUESTO PARA TRATAR O MEJORAR LA HD (ENFERMEDAD DE HUNTINGTON) EN UN INDIVIDUO QUE LO NECESITE QUE COMPRENDE ADMINISTRAR AL INDIVIDUO UNA CANTIDAD EFECTIVA DE UN COMPUESTO DE LA FÓRMULA (I) O UNA FORMA DEL MISMO, EN LA CUAL W1, W2, W3, W4, W5, W6 Y W7 SON COMO SE DEFINEN EN LA PRESENTE SOLICITUD. EN PARTICULAR, LA PRESENTE DESCRIPCIÓN SE REFIERE A UN MÉTODO DE USO DE UN COMPUESTO DE LA FÓRMULA (I) O UNA FORMA O COMPOSICIÓN DEL MISMO PARA TRATAR O MEJORAR LA HD EN UN INDIVIDUO QUE LO NECESITE QUE COMPRENDE, ADMINISTRAR AL INDIVIDUO UNA CANTIDAD EFECTIVA DEL COMPUESTO O UNA FORMA O COMPOSICIÓN DEL MISMO.

公开(公告)号：CA3104516A1

公开(公告)日：2020-01-02

申请号：CA3104516

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I) or (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：PL2812004T3

公开(公告)日：2019-01-31

申请号：PL13747100

申请日：2013-02-08

Applicant: PTC THERAPEUTICS INC ,  HOFFMANN LA ROCHE

Inventor： QI HONGYAN ,  CHOI SOONGYU ,  DAKKA AMAL ,  KARP GARY MITCHELL ,  NARASIMHAN JANA ,  NARYSHKIN NIKOLAI ,  TURPOFF ANTHONY A ,  WEETALL MARLA L ,  WELCH ELLEN ,  WOLL MATTHEW G ,  YANG TIANLE ,  ZHANG NANJING ,  ZHANG XIAOYAN ,  ZHAO XIN ,  GREEN LUKE ,  PINARD EMMANUEL ,  RATNI HASANE

IPC: A61K31/53 ,  A61K31/4375 ,  A61K31/519 ,  A61P25/00 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

公开(公告)号：CA3067591A1

公开(公告)日：2019-01-03

申请号：CA3067591

申请日：2018-06-27

Applicant: PTC THERAPEUTICS INC

Inventor： BHATTACHARYYA ANURADHA ,  JANI MINAKSHI B ,  SYDORENKO NADIYA ,  WOLL MATTHEW G

IPC: A61K31/519 ,  A61K31/551 ,  A61P25/14

Abstract: The present description relates to a method or use of a compound for treating or ameliorating HD (Huntington's Disease) in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I) or a form thereof, wherein w1, w2, w3, w4, w5, w6 and w7 are as defined herein. In particular, the present description relates to a method of use of a compound of Formula (I) or a form or composition thereof for treating or ameliorating HD in a subject in need thereof comprising, administering an effective amount of the compound or a form or composition thereof to the subject.