公开(公告)号：NO20064351A

公开(公告)日：2006-11-20

申请号：NO20064351

申请日：2006-09-26

Applicant: VERTEX PHARMA

Inventor： STUDLEY JOHN ,  CHARRIER JEAN-DAMIEN ,  MORTIMORE MICHAEL ,  DURRANT STEVEN ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  RAMAYA SHARN ,  TRUDEAU MARTIN ,  LOOKER ADAM

IPC: C07D207/16 ,  A61K31/439 ,  A61K38/04 ,  A61K38/06 ,  C07D209/52 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D417/06 ,  C07D417/12 ,  C07K5/02 ,  C07K5/04

CPC classification number: C07D405/12 ,  A61K38/06 ,  C07D207/16 ,  C07D209/52 ,  C07D401/12 ,  C07D401/14 ,  C07D417/06 ,  C07D417/12 ,  C07K5/0202 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389

Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.

公开(公告)号：CA2820541A1

公开(公告)日：2005-09-15

申请号：CA2820541

申请日：2005-02-28

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  MORTIMORE MICHAEL ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  RAMAYA SHARN ,  STUDLEY JOHN R ,  TRUDEAU MARTIN ,  LOOKER ADAM

IPC: C07K5/083 ,  A01N1/02 ,  A61K38/06 ,  C07D471/08 ,  C07K5/062

Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions. (see formula I)

公开(公告)号：CA2747252C

公开(公告)日：2018-09-18

申请号：CA2747252

申请日：2009-12-18

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  MORTIMORE MICHAEL ,  O'DONNELL MICHAEL ,  PINDER JOANNE ,  RUTHERFORD ALISTAIR ,  VIRANI ANISA NIZARALI ,  YOUNG STEPHEN ,  REAPER PHILIP MICHAEL

IPC: C07D413/04 ,  A61K31/497 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; pro-cesses for preparing the compounds of this invention; in-termediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The com-pounds of this invention have formula (I):wherein the variables are as defined herein.

公开(公告)号：AU2018201363A1

公开(公告)日：2018-03-15

申请号：AU2018201363

申请日：2018-02-26

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  MORTIMORE MICHAEL ,  O'DONNELL MICHAEL ,  PINDER JOANNE ,  RUTHERFORD ALISTAIR ,  YOUNG STEPHEN ,  REAPER PHILIP MICHAEL ,  VIRANI ANISA NIZARALI

IPC: C07D413/04 ,  A61K31/497 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04

Abstract: Abstract The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutical acceptable compositions comprising the compounds of this invention; me thods of treating of various diseases, disc rders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the com parative evaluation of n ew kin ase inhibitors. The compo un ds of this invention have formula (1):wherein the variables are as defined herein r N

公开(公告)号：AU2009327357C1

公开(公告)日：2017-02-02

申请号：AU2009327357

申请日：2009-12-18

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  MORTIMORE MICHAEL ,  O'DONNELL MICHAEL ,  PINDER JOANNE ,  RUTHERFORD ALISTAIR ,  VIRANI ANISA NIZARALI ,  YOUNG STEPHEN ,  REAPER PHILIP MICHAEL

IPC: C07D413/04 ,  A61K31/497 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in

公开(公告)号：AU2016203414A1

公开(公告)日：2016-06-23

申请号：AU2016203414

申请日：2016-05-25

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  O'DONNELL MICHAEL ,  KNEGTEI RONALD ,  MACCORMICK SOMHAIRLE ,  PINDER JOANNE ,  VIRANI ANISA ,  YOUNG STEPHEN ,  BINCH HAYLEY ,  CLEVELAND THOMAS ,  FANNING LEV ,  HURLEY DENNIS ,  JOSHI PRAMOD ,  SHETH URVI ,  SILINA ALINA

IPC: C07D401/04 ,  A61K31/4965 ,  A61P35/00 ,  C07D403/04 ,  C07D413/04

Abstract: Abstract The present invention relates to pyrazine compounds, pharmaceutical compositions comprising them, and methods for inhibiting ATR protein kinase for treating various diseases, disorders, and conditions including cancer, HIV, hepatitis, adenovirus and psoriasis. Additionally the invention discloses processes for preparing the compounds, intermediates used in the preparation, and methods of using the compounds in in vitro applications including the study of kinases in biological and pathological phenomena, the study of intracellular signal transduction pathways mediated by such kinases, and the comparative evaluation of new kinase inhibitors.

公开(公告)号：SG185524A1

公开(公告)日：2012-12-28

申请号：SG2012083176

申请日：2011-05-12

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  BINCH HAYLEY MARIE ,  HURLEY DENNIS JAMES ,  CLEVELAND THOMAS ,  JOSHI PRAMOD ,  FANNING LEV TYLER DEWEY ,  PINDER JOANNE ,  O'DONNELL MICHAEL ,  VIRANI ANISA NIZARALI ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  DURRANT STEVEN JOHN ,  YOUNG STEPHEN CLINTON ,  STORCK PIERRE-HENRI ,  KAY DAVID ,  REAPER PHILIP MICHAEL ,  GROTE MATTHEW PAUL

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I wherein the variables are as defined herein.

公开(公告)号：ZA201104498B

公开(公告)日：2012-10-31

申请号：ZA201104498

申请日：2011-06-17

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  MORTIMORE MICHAEL ,  O'DONNELL MICHAEL ,  PINDER JOANNE ,  RUTHERFORD ALISTAIR ,  VIRANI ANISA NIZARALI ,  YOUNG STEPHEN ,  REAPER PHILIP MICHAEL

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

公开(公告)号：HK1159614A1

公开(公告)日：2012-08-03

申请号：HK11114041

申请日：2011-12-29

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN J ,  DURRANT STEVEN ,  MORTIMORE MICHAEL ,  O'DONNELL MICHAEL ,  RUTHERFORD ALISTAIR ,  RAMAYA SHARN ,  STUDLEY JOHN R ,  TRUDEAU MARTIN ,  LOOKER ADAM

IPC: C07D20060101 ,  A61K20060101 ,  A61K38/04 ,  A61K38/06 ,  A61P20060101 ,  C07D207/16 ,  C07D209/52 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D417/06 ,  C07D417/12 ,  C07K5/02 ,  C07K5/04

Abstract: The present invention provides a compound of formula (I): wherein the variables are as defined herein. The present invention also provides processes for preparing the compounds of formula (I), and intermediates thereof, pharmaceutical compositions comprising those compounds, and methods of using the compounds and compositions.

公开(公告)号：NZ577798A

公开(公告)日：2012-04-27

申请号：NZ57779807

申请日：2007-12-21

Applicant: VERTEX PHARMA

Inventor： MORTIMORE MICHAEL ,  YOUNG STEPHEN CLINTON ,  EVERITT SIMON ROBERT LORRIE ,  KNEGTEL RONALD ,  PINDER JOANNE LOUISE ,  RUTHERFORD ALISTAIR PETER ,  DURRANT STEVEN ,  BRENCHLEY GUY ,  CHARRIER JEAN DAMIEN ,  O'DONNELL MICHAEL

IPC: A61K31/506 ,  A61K31/551 ,  A61P3/00 ,  A61P5/00 ,  A61P9/00 ,  A61P11/06 ,  A61P19/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00

Abstract: Disclosed is a 5-CYANO-4- (PYRROLO [2, 3B] PYRIDINE-3-YL) -PYRIMIDINE and derivatives that are useful as protein kinase inhibitors.