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公开(公告)号：WO02064550A8
公开(公告)日：2002-11-14
申请号：PCT/US0204501
申请日：2002-02-12
Applicant: ABBOTT LAB
Inventor： LINK JAMES T , SORENSEN BRYAN K , PATEL JYOTI R , ARENDSEN DAVID L , LI GAOQUAN
IPC: C07D317/32 , A61K31/11 , A61K31/136 , A61K31/18 , A61K31/197 , A61K31/223 , A61K31/343 , A61K31/351 , A61K31/357 , A61K31/365 , A61K31/381 , A61K31/401 , A61K31/4015 , A61K31/427 , A61K31/445 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P3/04 , A61P3/10 , A61P5/46 , A61P9/12 , A61P11/02 , A61P11/06 , A61P19/02 , A61P37/06 , A61P37/08 , C07C307/10 , C07C311/08 , C07D207/08 , C07D207/16 , C07D207/27 , C07D211/60 , C07D265/32 , C07D277/20 , C07D277/34 , C07D295/092 , C07D307/20 , C07D307/33 , C07D309/36 , C07D333/32 , C07D403/04 , C07C307/04
CPC classification number: C07D295/088 , C07C307/10 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18
Abstract: Compounds of formula (I) (I), or pharmaceutically acceptable salts thereof are novel glucocorticoid receptor modulators and are useful for treating type II diabetes in a mammal.
Abstract translation: 式（I）（I）化合物或其药学上可接受的盐是新型糖皮质激素受体调节剂，可用于治疗哺乳动物的II型糖尿病。
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公开(公告)号：WO02070507A3
公开(公告)日：2002-11-21
申请号：PCT/US0204541
申请日：2002-01-16
Applicant: ABBOTT LAB
Inventor： KYM PHILIP R , LANE BENJAMIN C , PRATT JOHN K , VON GELDERN TOM , WINN MARTIN , PATEL JYOTI R , ARENDSEN DAVID L , AKRITOPOULOU-ZANZE IRINI , ASHWORTH KIMBA L , HARTANDI KRESNA , BRENNEMAN JEHROD
IPC: A61P3/10 , A61P7/12 , C07D311/80 , C07D407/04 , C07D409/04 , A61K31/352 , C07D405/04
CPC classification number: C07D407/04 , C07D311/80 , C07D409/04
Abstract: Compounds of formula (I) are useful for treating type (II) diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 式（I）化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除率不足，高胰岛素血症，高甘油三酯血症和高循环性糖皮质激素水平，化合物的制剂，含该化合物的组合物，以及使用 化合物。
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公开(公告)号：WO9962908A3
公开(公告)日：2000-03-30
申请号：PCT/US9912419
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗炎症。 还公开了包含式（I）的化合物的药物组合物，以及哺乳动物抑制/治疗炎性疾病的方法。
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公开(公告)号：PL345906A1
公开(公告)日：2002-01-14
申请号：PL34590699
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/435 , A61K31/50 , A61K31/505
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：AT206390T
公开(公告)日：2001-10-15
申请号：AT96912978
申请日：1996-04-18
Applicant: ABBOTT LAB
Inventor： ARENDSEN DAVID L , BAKER WILLIAM R , FAKHOURY STEPHEN A , FUNG K L ANTHONY , GARVEY DAVID S , MCCLELLAN WILLIAM J , O'CONNOR STEPHEN J , PRASAD RAJNANDAN N , ROCKWAY TODD W , ROSENBERG SAUL H , STEIN HERMAN H , SHEN WANG , STOUT DAVID M , SULLIVAN GERARD M , AUGERI DAVID J
IPC: A61K31/195 , A61K31/215 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/433 , A61P3/06 , A61P9/00 , A61P9/08 , A61P31/04 , A61P35/00 , A61P43/00 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07C235/82 , C07D271/06 , C07D271/10 , C07D285/10 , C07D333/20 , A61K31/19
Abstract: The present invention provides a compound of formula (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
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Patent Agency Ranking
公开(公告)号：TR200100189T2
公开(公告)日：2001-05-21
申请号：TR200100189
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/505
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：NO20006157A
公开(公告)日：2001-02-02
申请号：NO20006157
申请日：2000-12-04
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
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公开(公告)号：SK18542000A3
公开(公告)日：2001-12-03
申请号：SK18542000
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：BG105109A
公开(公告)日：2001-11-30
申请号：BG10510901
申请日：2001-01-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
Abstract: Compounds having formula are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising said compounds, and methods of inhibiting/treating inflammatory diseases in a mammal. 23 claims, 1 figure
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公开(公告)号：NO20006157D0
公开(公告)日：2000-12-04
申请号：NO20006157
申请日：2000-12-04
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
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