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1.发明申请(1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE 审中-公开（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷
公开(公告)号：WO2006019660A3
公开(公告)日：2006-05-11
申请号：PCT/US2005024447
申请日：2005-07-08
Applicant: ABBOTT LAB , BUCKLEY MICHAEL J , JI JIANGUO , ZHANG GEOFF G , HENRY RODGER F , WANG WEILI W , WAYNE GREG S , LI WENKE , TOWNE TIMOTHY B , WITTENBERGER STEVEN J , HANNICK STEVEN M , KOTECKI BRIAN J , MARCI BRYAN S , ROBBINS TIMOTHY A
Inventor： BUCKLEY MICHAEL J , JI JIANGUO , ZHANG GEOFF G , HENRY RODGER F , WANG WEILI W , WAYNE GREG S , LI WENKE , TOWNE TIMOTHY B , WITTENBERGER STEVEN J , HANNICK STEVEN M , KOTECKI BRIAN J , MARCI BRYAN S , ROBBINS TIMOTHY A
IPC: C07D487/04 , A61K31/4439
CPC classification number: C07D487/04
Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
Abstract translation: 本发明公开了（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷及其盐，其用于治疗与 烟碱乙酰胆碱受体。
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公开(公告)号：NZ552520A
公开(公告)日：2010-09-30
申请号：NZ55252005
申请日：2005-07-08
Applicant: ABBOTT LAB
Inventor： BUCKLEY MICHAEL J , JL JIANGUO , ZHANG GEOFF G , HENRY RODGER F , WANG WEILI W , WAYNE GREG S , LL WENKE , TOWNE TIMOTHY B , WITTENBERGER STEVEN J , HANNICK STEVEN M , KOTECKI BRIAN J , MARCI BRYAN S , ROBBINS TIMOTHY A
IPC: A61K31/4439 , C07D487/04
Abstract: Disclosed is a salt of (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, selected from the group consisting of acetate, citrate, fumarate, hemicitrate, hydrocholoride, maleate, methanesulfonate, 4-methylbenzenesulfonate, sulphate, L-tartrate and trifluoroacetate. Also disclosed is a process for preparing a compound of formula (5J) comprising the steps of a) treating compound (5D), with an aqueous acid; b) treating the mixture from step (a) with a compound of formula (A), wherein R2 is phenyl optionally substituted with alkyl, alkoxy or halo in the presence of magnesium bromide in a mixture of isopropyl alcohol and dichloromethane to provide a compound of formula (B), c) using the compound of formula (B) to prepare the compound (5J).
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3.发明专利
公开(公告)号：NZ588123A
公开(公告)日：2012-04-27
申请号：NZ58812304
申请日：2004-05-20
Applicant: ABBOTT LAB
Inventor： BUCKLEY MICHAEL J , JI JIANGUO
IPC: C07D487/04 , A61K31/397 , A61K31/407 , A61K31/4439 , A61P29/00 , C07D213/61 , C07D213/74
Abstract: Disclosed is a pharmaceutical composition for treating amyotrophic lateral sclerosis or premenstrual syndrome which comprises a therapeutically effective amount of (1S,5S)-3-(5,6-dichloro-pyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane or a pharmaceutically acceptable salt thereof. Further disclosed is a pharmaceutical composition comprising a therapeutically effective amount of (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, wherein the composition is in a solid dosage form or a liquid dosage form. Also disclosed is (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane (L)-tartrate and (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane p-toluenesulfonate.
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4.发明专利
公开(公告)号：SI1626973T1
公开(公告)日：2011-01-31
申请号：SI200431546
申请日：2004-05-20
Applicant: ABBOTT LAB
Inventor： BUCKLEY MICHAEL J , JI JIANGUO
IPC: C07D487/00 , A61K31/00 , A61P29/00 , C07D487/04
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5.发明专利
公开(公告)号：ZA200509601B
公开(公告)日：2006-10-25
申请号：ZA200509601
申请日：2005-11-28
Applicant: ABBOTT LAB
Inventor： BUCKLEY MICHAEL J , JIANGUO JI
IPC: A61K20090101 , A61P20090101 , A61P29/00 , C07D20090101 , C07D487/04
Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
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Patent Agency Ranking
公开(公告)号：AU2005275387A1
公开(公告)日：2006-02-23
申请号：AU2005275387
申请日：2005-07-08
Applicant: ABBOTT LAB
Inventor： KOTECKI BRIAN J , JI JIANGUO , LI WENKE , HANNICK STEVEN M , ZHANG GEOFF G , WAYNE GREG S , ROBBINS TIMOTHY A , BUCKLEY MICHAEL J , WANG WEILI W , WITTENBERGER STEVEN J , HENRY RODGER F , MARCI BRYAN S , TOWNE TIMOTHY B
IPC: C07D487/04 , A61K31/4439
Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
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7.发明专利
公开(公告)号：CA2526530C
公开(公告)日：2013-01-08
申请号：CA2526530
申请日：2004-05-20
Applicant: ABBOTT LAB
Inventor： BUCKLEY MICHAEL J , JI JIANGUO
IPC: C07D487/04 , A61K31/407 , A61P29/00 , C07D205/00 , C07D209/00
Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
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8.发明专利
公开(公告)号：DK1626973T3
公开(公告)日：2011-01-10
申请号：DK04752844
申请日：2004-05-20
Applicant: ABBOTT LAB
Inventor： BUCKLEY MICHAEL J , JI JIANGUO
IPC: C07D487/04 , A61K31/407 , A61P29/00
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9.发明专利
公开(公告)号：PT1626973E
公开(公告)日：2010-12-31
申请号：PT04752844
申请日：2004-05-20
Applicant: ABBOTT LAB
Inventor： JI JIANGUO , BUCKLEY MICHAEL J
IPC: C07D487/04 , A61K31/407 , A61P29/00
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10.发明专利
公开(公告)号：DE602004029671D1
公开(公告)日：2010-12-02
申请号：DE602004029671
申请日：2004-05-20
Applicant: ABBOTT LAB
Inventor： BUCKLEY MICHAEL J , JI JIANGUO
IPC: C07D487/04 , A61K31/407 , A61P29/00
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