公开(公告)号：NZ552520A

公开(公告)日：2010-09-30

申请号：NZ55252005

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JL JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LL WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: A61K31/4439 ,  C07D487/04

Abstract: Disclosed is a salt of (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, selected from the group consisting of acetate, citrate, fumarate, hemicitrate, hydrocholoride, maleate, methanesulfonate, 4-methylbenzenesulfonate, sulphate, L-tartrate and trifluoroacetate. Also disclosed is a process for preparing a compound of formula (5J) comprising the steps of a) treating compound (5D), with an aqueous acid; b) treating the mixture from step (a) with a compound of formula (A), wherein R2 is phenyl optionally substituted with alkyl, alkoxy or halo in the presence of magnesium bromide in a mixture of isopropyl alcohol and dichloromethane to provide a compound of formula (B), c) using the compound of formula (B) to prepare the compound (5J).