公开(公告)号：WO2006019660A3

公开(公告)日：2006-05-11

申请号：PCT/US2005024447

申请日：2005-07-08

Applicant: ABBOTT LAB ,  BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

Inventor： BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: C07D487/04 ,  A61K31/4439

CPC classification number: C07D487/04

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

Abstract translation: 本发明公开了（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷及其盐，其用于治疗与 烟碱乙酰胆碱受体。

公开(公告)号：BRPI0513719A

公开(公告)日：2008-05-13

申请号：BRPI0513719

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: C07D487/04 ,  A61K31/4439

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：NZ552520A

公开(公告)日：2010-09-30

申请号：NZ55252005

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JL JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LL WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: A61K31/4439 ,  C07D487/04

Abstract: Disclosed is a salt of (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, selected from the group consisting of acetate, citrate, fumarate, hemicitrate, hydrocholoride, maleate, methanesulfonate, 4-methylbenzenesulfonate, sulphate, L-tartrate and trifluoroacetate. Also disclosed is a process for preparing a compound of formula (5J) comprising the steps of a) treating compound (5D), with an aqueous acid; b) treating the mixture from step (a) with a compound of formula (A), wherein R2 is phenyl optionally substituted with alkyl, alkoxy or halo in the presence of magnesium bromide in a mixture of isopropyl alcohol and dichloromethane to provide a compound of formula (B), c) using the compound of formula (B) to prepare the compound (5J).

公开(公告)号：AU2005275387A1

公开(公告)日：2006-02-23

申请号：AU2005275387

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： KOTECKI BRIAN J ,  JI JIANGUO ,  LI WENKE ,  HANNICK STEVEN M ,  ZHANG GEOFF G ,  WAYNE GREG S ,  ROBBINS TIMOTHY A ,  BUCKLEY MICHAEL J ,  WANG WEILI W ,  WITTENBERGER STEVEN J ,  HENRY RODGER F ,  MARCI BRYAN S ,  TOWNE TIMOTHY B

IPC: C07D487/04 ,  A61K31/4439

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：CA2573688C

公开(公告)日：2013-05-28

申请号：CA2573688

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MACRI BRYAN S ,  ROBBINS TIMOTHY A

IPC: C07D487/04 ,  A61K31/4439

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：ZA200901558B

公开(公告)日：2010-01-27

申请号：ZA200901558

申请日：2009-03-04

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  TOWNE TIMOTHY B ,  WANG WEILI W ,  ZHANG GEOFF G ,  HANNICK STEVEN M ,  JI JIANGUO ,  LI WENKE ,  ROBBINS TIMOTHY A ,  WITTENBERGER STEVEN J ,  WAYNE GREG S

IPC: A61K20100101 ,  A61K31/4439 ,  C07D20100101 ,  C07D487/04

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：ZA200700510B

公开(公告)日：2009-07-29

申请号：ZA200700510

申请日：2007-01-17

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  ZHANG GEOFF G ,  WANG WEILI W ,  WENKE LI ,  WITTENBERGER STEVEN J ,  KOTECKI BRIAN J ,  ROBBINS TIMOTHY A ,  JIANGUO JI ,  HENRY RODGER F ,  WAYNE GREG S ,  TOWNE TIMOTHY B ,  HANNICK STEVEN M ,  MARCI BRYAN S

IPC: A61K20090101 ,  A61K31/4439 ,  C07D20090101 ,  C07D487/04

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：MX2007000948A

公开(公告)日：2007-04-16

申请号：MX2007000948

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JI JIANGUO ,  ROBBINS TIMOTHY A ,  WITTENBERGER STEVEN J ,  HENRY RODGER F ,  WAYNE GREG S ,  ZHANG GEOFF G ,  WANG WEILI W ,  LI WENKE ,  TOWNE TIMOTHY B ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S

IPC: A61K31/4439 ,  C07D487/04

Abstract: La presente invencion describe (1s, 5s)-3-(5, 6-dicloro-3 -piridinil)-3, 6-diazabiciclo [3.2.0] heptano, sales del mismo, y su uso en tratar dolor y otros trastornos con el receptor de la aceticolina nicotinica.

公开(公告)号：CA2573688A1

公开(公告)日：2006-02-23

申请号：CA2573688

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： HANNICK STEVEN M ,  HENRY RODGER F ,  ROBBINS TIMOTHY A ,  WAYNE GREG S ,  WITTENBERGER STEVEN J ,  WANG WEILI W ,  LI WENKE ,  TOWNE TIMOTHY B ,  MARCI BRYAN S ,  BUCKLEY MICHAEL J ,  KOTECKI BRIAN J ,  ZHANG GEOFF G ,  JI JIANGUO

IPC: C07D487/04 ,  A61K31/4439

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.