公开(公告)号：WO2006019660A3

公开(公告)日：2006-05-11

申请号：PCT/US2005024447

申请日：2005-07-08

Applicant: ABBOTT LAB ,  BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

Inventor： BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: C07D487/04 ,  A61K31/4439

CPC classification number: C07D487/04

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

Abstract translation: 本发明公开了（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷及其盐，其用于治疗与 烟碱乙酰胆碱受体。

公开(公告)号：BRPI0513719A

公开(公告)日：2008-05-13

申请号：BRPI0513719

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: C07D487/04 ,  A61K31/4439

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：ES2229691T3

公开(公告)日：2005-04-16

申请号：ES99914082

申请日：1999-03-23

Applicant: ABBOTT LAB

Inventor： WANG XIU C ,  BHATIA ASHOK V ,  HOSSAIN AZAD ,  TOWNE TIMOTHY B

IPC: C07B61/00 ,  C07C51/353 ,  C07C403/20 ,  C11C3/00

Abstract: Un procedimiento para producir un compuesto de fórmula IV: **(Fórmula)** que comprende las etapas de: a) hacer reaccionar en un disolvente en presencia de una base débil, un butenólido de fórmula II: **(Fórmula)** con una sal de fórmula: **(Fórmula)** en la que R1, R2 y R3 se seleccionan independientemente entre arilo o dialquilamino, R4 y R5 se seleccionan independientemente entre hidrógeno, alquilo inferior, alcoxi, cicloalquilo, arilo, o anillo heterocíclico, y X se selecciona entre halógeno o hidrogenosulfato, para formar una mezcla de reacción; y b) recuperar el compuesto de la mezcla de reacción.

公开(公告)号：AU2005275387A1

公开(公告)日：2006-02-23

申请号：AU2005275387

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： KOTECKI BRIAN J ,  JI JIANGUO ,  LI WENKE ,  HANNICK STEVEN M ,  ZHANG GEOFF G ,  WAYNE GREG S ,  ROBBINS TIMOTHY A ,  BUCKLEY MICHAEL J ,  WANG WEILI W ,  WITTENBERGER STEVEN J ,  HENRY RODGER F ,  MARCI BRYAN S ,  TOWNE TIMOTHY B

IPC: C07D487/04 ,  A61K31/4439

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：CA2325517A1

公开(公告)日：1999-09-30

申请号：CA2325517

申请日：1999-03-23

Applicant: ABBOTT LAB

Inventor： BHATIA ASHOK V ,  HOSSAIN AZAD ,  WANG XIU C ,  TOWNE TIMOTHY B

IPC: C07B61/00 ,  C07C51/353 ,  C07C403/20 ,  C11C3/00

Abstract: The process of the present invention relates to a process for producing 13-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and optionally, a Lewis acid.

公开(公告)号：NZ552520A

公开(公告)日：2010-09-30

申请号：NZ55252005

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JL JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LL WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: A61K31/4439 ,  C07D487/04

Abstract: Disclosed is a salt of (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, selected from the group consisting of acetate, citrate, fumarate, hemicitrate, hydrocholoride, maleate, methanesulfonate, 4-methylbenzenesulfonate, sulphate, L-tartrate and trifluoroacetate. Also disclosed is a process for preparing a compound of formula (5J) comprising the steps of a) treating compound (5D), with an aqueous acid; b) treating the mixture from step (a) with a compound of formula (A), wherein R2 is phenyl optionally substituted with alkyl, alkoxy or halo in the presence of magnesium bromide in a mixture of isopropyl alcohol and dichloromethane to provide a compound of formula (B), c) using the compound of formula (B) to prepare the compound (5J).

公开(公告)号：PT1066253E

公开(公告)日：2004-10-29

申请号：PT99914082

申请日：1999-03-23

Applicant: ABBOTT LAB

Inventor： BHATIA ASHOK V ,  WANG XIU C ,  HOSSAIN AZAO ,  TOWNE TIMOTHY B

IPC: C07B61/00 ,  C07C51/353 ,  C07C403/20 ,  C11C3/00

Abstract: The process of the present invention relates to a process for producing 1 3-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and a Lewis acid.

公开(公告)号：AT269847T

公开(公告)日：2004-07-15

申请号：AT99914082

申请日：1999-03-23

Applicant: ABBOTT LAB

Inventor： WANG XIU C ,  BHATIA ASHOK V ,  HOSSAIN AZAD ,  TOWNE TIMOTHY B

IPC: C07B61/00 ,  C07C51/353 ,  C07C403/20 ,  C11C3/00

Abstract: The process of the present invention relates to a process for producing 1 3-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and a Lewis acid.

公开(公告)号：CA2573688C

公开(公告)日：2013-05-28

申请号：CA2573688

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MACRI BRYAN S ,  ROBBINS TIMOTHY A

IPC: C07D487/04 ,  A61K31/4439

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：ZA200901558B

公开(公告)日：2010-01-27

申请号：ZA200901558

申请日：2009-03-04

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  TOWNE TIMOTHY B ,  WANG WEILI W ,  ZHANG GEOFF G ,  HANNICK STEVEN M ,  JI JIANGUO ,  LI WENKE ,  ROBBINS TIMOTHY A ,  WITTENBERGER STEVEN J ,  WAYNE GREG S

IPC: A61K20100101 ,  A61K31/4439 ,  C07D20100101 ,  C07D487/04

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.