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公开(公告)号：WO0181316A3
公开(公告)日：2002-05-23
申请号：PCT/US0113678
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： WANG WEI-BO , CURTIN MICHAEL L , FAKHOURY STEPHEN A , GWALTNEY STEPHEN L II , HASVOLD LISA A , HUTCHINS CHARLES W , LI QUI , LIN NAN-HORNG , JENNINGS NELSON LISSA TAKA , O'CONNOR STEPHEN J , SHAM HING L , SULLIVAN GERALD M , WANG GARY T , WANG XILU
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , A61K31/33 , C07D213/74 , C07D409/12
CPC classification number: C07D213/30 , C07D213/36 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/08 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D409/10 , C07D413/12 , C07D417/06
Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
Abstract translation: 式（I）化合物或其药学上可接受的盐抑制法呢基转移酶。 公开了制备该化合物的方法，含该化合物的药物组合物和使用该化合物的治疗方法。
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公开(公告)号：AU5921801A
公开(公告)日：2001-11-07
申请号：AU5921801
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： WANG WEI-BO , CURTIN MICHAEL L , FAKHOURY STEPHEN A , GWALTNEY STEPHEN L II , HASVOLD LISA A , HUTCHINS CHARLES W , LI QUI , LIN NAN-HORNG , NELSON LISSA TAKA JENNINGS , O'CONNOR STEPHEN J , SHAM HING L , SULLIVAN GERALD M , WANG GARY T , WANG XILU
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , C07D233/00
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公开(公告)号：AU5673196A
公开(公告)日：1996-11-21
申请号：AU5673196
申请日：1996-05-02
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROSENBERG SAUL H , FUNG K L ANTHONY , ROCKWAY TODD W , FAKHOURY STEPHEN A , GARVEY DAVID S , DONNER B GREGORY , O'CONNOR STEPHEN J , PRASAD RAJNANDAN N , SHEN WANG , STOUT DAVID M , SULLIVAN GERARD M
IPC: C07C65/24 , C07C65/28 , C07C65/40 , C07C69/94 , C07C229/38 , C07C233/22 , C07C233/65 , C07C233/69 , C07C233/73 , C07C233/87 , C07C235/16 , C07C235/34 , C07C235/42 , C07C235/48 , C07C235/60 , C07C235/84 , C07C237/08 , C07C237/20 , C07C237/32 , C07C251/48 , C07C255/57 , C07C259/10 , C07C271/48 , C07C275/42 , C07C311/08 , C07C311/29 , C07C311/51 , C07C323/59 , C07C327/48 , C07C333/04 , C07D209/16 , C07D213/40 , C07D231/12 , C07D271/10 , C07D271/113 , C07D307/88 , C07D307/89 , C07D309/32 , C07D311/68 , C07D319/06 , C07D333/20 , C07C235/38 , C07D257/04 , C07C335/22 , C07C233/12
Abstract: The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.
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4.发明专利
公开(公告)号：CA2218597A1
公开(公告)日：1996-10-24
申请号：CA2218597
申请日：1996-04-18
Applicant: ABBOTT LAB
Inventor： STEIN HERMAN H , FUND K L ANTHONY , AUGERI DAVID J , BAKER WILLIAM R , SULLIVAN GERARD M , ROSENBERG SAUL H , O'CONNOR STEPHEN J , FAKHOURY STEPHEN A , PRASAD RAJNANDAN N , STOUT DAVID M , SHEN WANG , ROCKWAY TODD W , MCCLELLAN WILLIAM J , GARVEY DAVIS S , ARENDSEN DAVID L
IPC: A61K31/195 , A61K31/215 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/433 , A61P3/06 , A61P9/00 , A61P9/08 , A61P31/04 , A61P35/00 , A61P43/00 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07C235/82 , C07D271/06 , C07D271/10 , C07D285/10 , C07D333/20 , A61K38/04 , C07D215/14 , A61K31/16 , A61K31/19 , C07D333/24 , C07D263/32 , A61K31/33 , C07C323/40 , C07C317/44 , C07C311/45 , C07D307/54 , C07D213/56 , C07C233/57 , C07D317/60 , C07D333/60
Abstract: The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
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公开(公告)号：AT177420T
公开(公告)日：1999-03-15
申请号：AT94931987
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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Patent Agency Ranking
公开(公告)号：CA2407093A1
公开(公告)日：2001-11-01
申请号：CA2407093
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： GWALTNEY STEPHEN L II , SULLIVAN GERALD M , WANG GARY T , FAKHOURY STEPHEN A , HUTCHINS CHARLES W , LI QUN , SHAM HING L , HASVOLD LISA A , WANG XILU , LIN NAN-HORNG , CURTIN MICHAEL L , WANG WEI-BO , O'CONNOR STEPHEN J , JENNINGS NELSON LISSA TAKA
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , A61K31/33 , C07D213/74 , C07D409/12
Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhib it farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
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7.发明专利
公开(公告)号：GR3030342T3
公开(公告)日：1999-09-30
申请号：GR990401431
申请日：1999-05-27
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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公开(公告)号：ZA963237B
公开(公告)日：1996-07-29
申请号：ZA963237
申请日：1996-04-23
Applicant: ABBOTT LAB
Inventor： SHEN WANG , ROSENBERG SAUL H , ARENDSEN DAVID L , O'CONNOR STEPHEN J , FAKHOURY STEPHEN A , GARVEY DAVID S , FUNG ANTHONY K L , STEIN HERMAN H
IPC: A61K20060101 , C07C20060101 , C07D20060101 , A61K , C07C , C07D
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公开(公告)号：ZA9603237B
公开(公告)日：1996-07-29
申请号：ZA9603237
申请日：1996-04-23
Applicant: ABBOTT LAB
Inventor： SHEN WANG , ROSENBERG SAUL H , ARENDSEN DAVID L , O'CONNOR STEPHEN J , FAKHOURY STEPHEN A , GARVEY DAVID S , FUNG ANTHONY K L , STEIN HERMAN H
IPC: A61K20060101 , C07C20060101 , C07D20060101 , A61K , C07C , C07D
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10.发明专利
公开(公告)号：CA2152822A1
公开(公告)日：1995-05-11
申请号：CA2152822
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , C07C235/82 , A61K31/33 , C07D207/337 , C07D249/02 , C07D285/06 , C07D307/54 , C07D333/24
Abstract: The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disorders resulting from an excess of cholesterol or cancer or a fungal infection.
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