公开(公告)号：WO9640937A3

公开(公告)日：1997-08-21

申请号：PCT/US9608097

申请日：1996-05-31

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  HALBERT DONALD N ,  KERWIN JAMES F JR ,  MCNALLY TERESA

IPC: C12N15/09 ,  A61K38/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/54 ,  C12R1/19

CPC classification number: C12N9/1205 ,  A61K38/00

Abstract: The present invention provides an isolated and purified polynucleotide that encodes mammalian adenosine kinase, and to an isolated and purified adenosine kinase polypeptide. Human recombinant adenosine kinase and methods of using adenosine kinase polypeptides are also provided. Methods of making recombinant adenosine kinase using those polynucleotides and host cells transformed with those polynucleotides are also provided.

公开(公告)号：WO9100725A2

公开(公告)日：1991-01-24

申请号：PCT/US9003630

申请日：1990-06-26

Applicant: ABBOTT LAB

Inventor： KERWIN JAMES F JR

IPC: A61K31/16 ,  A61K31/195 ,  A61K31/27 ,  A61K31/38 ,  A61K31/381 ,  A61K31/47 ,  A61K38/00 ,  A61P1/00 ,  A61P3/04 ,  A61P3/08 ,  A61P25/00 ,  A61P25/04 ,  C07C237/06 ,  C07C237/20 ,  C07C237/22 ,  C07C255/24 ,  C07C255/29 ,  C07C255/41 ,  C07C271/22 ,  C07C271/24 ,  C07C275/42 ,  C07C275/62 ,  C07C311/13 ,  C07C311/19 ,  C07C317/14 ,  C07C323/58 ,  C07C327/38 ,  C07C335/04 ,  C07D207/16 ,  C07D209/20 ,  C07D209/42 ,  C07D213/56 ,  C07D213/75 ,  C07D213/82 ,  C07D215/48 ,  C07D215/54 ,  C07D215/56 ,  C07D233/54 ,  C07D295/185 ,  C07D307/84 ,  C07D333/20 ,  C07D333/24 ,  C07D333/70 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07K5/02 ,  C07K5/078

CPC classification number: C07D213/82 ,  A61K38/00 ,  C07C237/06 ,  C07C237/20 ,  C07C237/22 ,  C07C255/29 ,  C07C255/41 ,  C07C271/22 ,  C07C271/24 ,  C07C275/62 ,  C07C317/14 ,  C07C323/58 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/42 ,  C07D213/56 ,  C07D215/48 ,  C07D215/54 ,  C07D215/56 ,  C07D233/54 ,  C07D295/185 ,  C07D307/84 ,  C07D333/24 ,  C07D333/70 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07K5/0202 ,  C07K5/06139

Abstract: A CCK antagonist compound of formula (I) wherein G is (1) NH2 or (2) substituted amino; R9 is (1) hydrogen, (2) loweralkyl, (3) carboxy-substituted alkyl or (4) carboxyester-substituted alkyl; R10 is (1) hydrogen, (2) loweralkyl, (3) functionalized alkyl or (4) cycloalkyl; D is (1) hydrogen, (2) loweralkyl, (3) functionalized alkyl, (4) cycloalkyl, (5) aryl, (6) functionalized oxyalkyl or (7) heterocyclic; with the proviso that D is other than indolylmethyl, indolinylmethyl or oxindolylmethyl; or R10 taken together with D or R9 taken together with D forms a cyclic group; Z is (1) -C(O)-, (2) -C(S)- or (3) -S(O)2-; B is (1) absent, (2) alkylene, (3) alkenylene, (4) substituted alkenylene, (5) -R26-R27- wherein R26 is absent or -CH2- and R27 is -O-, -S-, -NH- or -N(loweralkyl)- or (6) -R27-CH2- wherein R27 is defined as above; and Ar is (1) aryl or (2) a heterocyclic group.

Abstract translation: 其中G是（1）NH 2或（2）取代的氨基的式（I）的CCK拮抗剂化合物; R9是（1）氢，（2）低级烷基，（3）羧基取代的烷基或（4）羧酯取代的烷基; R10是（1）氢，（2）低级烷基，（3）官能化烷基或（4）环烷基; D为（1）氢，（2）低级烷基，（3）官能化烷基，（4）环烷基，（5）芳基，（6）官能化烷氧基或（7） 条件是D不是吲哚基甲基，二氢吲哚基甲基或羟吲哚基甲基; 或R 10与D或R9一起与D一起形成环状基团; Z是（1）-C（O） - ，（2）-C（S） - 或（3）-S（O） B是（1）不存在，（2）亚烷基，（3）亚烯基，（4）取代的亚烯基，（5）-R26-R27-，其中R26不存在或-CH2-和R27是-O - ， - S-， -NH-或-N（低级烷基） - 或（6）-R27-CH2-，其中R27如上定义; 和Ar是（1）芳基或（2）杂环基。

公开(公告)号：WO9100725A3

公开(公告)日：1991-02-21

申请号：PCT/US9003630

申请日：1990-06-26

Applicant: ABBOTT LAB

Inventor： KERWIN JAMES F JR

IPC: A61K31/16 ,  A61K31/195 ,  A61K31/27 ,  A61K31/38 ,  A61K31/381 ,  A61K31/47 ,  A61K38/00 ,  A61P1/00 ,  A61P3/04 ,  A61P3/08 ,  A61P25/00 ,  A61P25/04 ,  C07C237/06 ,  C07C237/20 ,  C07C237/22 ,  C07C255/24 ,  C07C255/29 ,  C07C255/41 ,  C07C271/22 ,  C07C271/24 ,  C07C275/42 ,  C07C275/62 ,  C07C311/13 ,  C07C311/19 ,  C07C317/14 ,  C07C323/58 ,  C07C327/38 ,  C07C335/04 ,  C07D207/16 ,  C07D209/20 ,  C07D209/42 ,  C07D213/56 ,  C07D213/75 ,  C07D213/82 ,  C07D215/48 ,  C07D215/54 ,  C07D215/56 ,  C07D233/54 ,  C07D295/185 ,  C07D307/84 ,  C07D333/20 ,  C07D333/24 ,  C07D333/70 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07K5/02 ,  C07K5/078 ,  A61K

CPC classification number: C07D213/82 ,  A61K38/00 ,  C07C237/06 ,  C07C237/20 ,  C07C237/22 ,  C07C255/29 ,  C07C255/41 ,  C07C271/22 ,  C07C271/24 ,  C07C275/62 ,  C07C317/14 ,  C07C323/58 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/42 ,  C07D213/56 ,  C07D215/48 ,  C07D215/54 ,  C07D215/56 ,  C07D233/54 ,  C07D295/185 ,  C07D307/84 ,  C07D333/24 ,  C07D333/70 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07K5/0202 ,  C07K5/06139

Abstract: A CCK antagonist compound of formula (I) wherein G is (1) NH2 or (2) substituted amino; R9 is (1) hydrogen, (2) loweralkyl, (3) carboxy-substituted alkyl or (4) carboxyester-substituted alkyl; R10 is (1) hydrogen, (2) loweralkyl, (3) functionalized alkyl or (4) cycloalkyl; D is (1) hydrogen, (2) loweralkyl, (3) functionalized alkyl, (4) cycloalkyl, (5) aryl, (6) functionalized oxyalkyl or (7) heterocyclic; with the proviso that D is other than indolylmethyl, indolinylmethyl or oxindolylmethyl; or R10 taken together with D or R9 taken together with D forms a cyclic group; Z is (1) -C(O)-, (2) -C(S)- or (3) -S(O)2-; B is (1) absent, (2) alkylene, (3) alkenylene, (4) substituted alkenylene, (5) -R26-R27- wherein R26 is absent or -CH2- and R27 is -O-, -S-, -NH- or -N(loweralkyl)- or (6) -R27-CH2- wherein R27 is defined as above; and Ar is (1) aryl or (2) a heterocyclic group.

公开(公告)号：WO0007997A8

公开(公告)日：2000-05-04

申请号：PCT/US9917739

申请日：1999-08-06

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  MEYER MICHAEL D ,  KERWIN JAMES F JR ,  HOLLADAY MARK W ,  KHILEVICH ALBERT ,  KOLASA TEODOZYJ ,  ROHDE JEFFREY ,  CARROLL WILLIAM A

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  A61P43/00 ,  C07D233/38 ,  C07D233/54 ,  C07D233/61 ,  C07D233/66 ,  C07D233/84 ,  C07D263/32 ,  C07D263/48 ,  C07D277/20 ,  C07D277/28 ,  C07D277/40 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D233/64 ,  C07D233/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D409/12 ,  C07D417/12

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with alpha 1A agonists. Also disclosed are alpha 1A agonist compositions and a method of activating alpha 1 adrenoceptors in a mammal.

Abstract translation: 具有式（I）的化合物可用于治疗α1A激动剂所预防或改善的疾病。 还公开了α1A激动剂组合物和激活哺乳动物中α1肾上腺素能受体的方法。

公开(公告)号：MX9705675A

公开(公告)日：1997-10-31

申请号：MX9705675

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA J ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  PRATY JOHN K

IPC: A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  C07D487/02 ,  C07D495/02 ,  C07D487/00 ,  C07D239/00 ,  C07D209/00 ,  C07D333/00

Abstract: La presente invencion se refiere a un compuesto de la Formula (I), y a las sales farmacéuticamente aceptables del mismo, en donde W es un sistema de anillo heterocíclico bicíclico. Los compuestos son antagonistas adrenérgicos alfa-1, y son utiles en el tratamiento de hiperplasia prostática benigna; también se describen composiciones antagonistas de alfa-1, y un método para antagonizar receptores de alfa-1, y para el tratamiento de hiperplasia prostática benigna.

公开(公告)号：MX9307363A

公开(公告)日：1994-05-31

申请号：MX9307363

申请日：1993-11-24

Applicant: ABBOTT LAB

Inventor： COWART MARLON ,  KERWIN JAMES F JR

IPC: C07C215/18 ,  C07C215/20 ,  C07C215/24 ,  C07C215/30 ,  C07C229/26 ,  C07C229/42 ,  C07C233/47 ,  C07C233/51 ,  C07C233/63 ,  C07C233/83 ,  C07C255/58 ,  C07C271/20 ,  C07C271/22 ,  C07C323/25 ,  C07C323/58 ,  C07D263/04 ,  C07D307/68 ,  C07D333/20 ,  C07D333/24 ,  A61K31/33

公开(公告)号：GR3034485T3

公开(公告)日：2000-12-29

申请号：GR20000402174

申请日：2000-09-26

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：AU3616800A

公开(公告)日：2000-09-21

申请号：AU3616800

申请日：2000-03-06

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  CHEN YIYUAN ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  MOORE JIMMIE L

IPC: A61K31/435 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/10 ,  A61P25/08 ,  A61P25/28 ,  C07C45/29 ,  C07D221/04 ,  C07D221/06 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D211/82 ,  C07D215/20 ,  C07D211/90 ,  A61K31/473

Abstract: Compounds of formula Iare useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：AU705283B2

公开(公告)日：1999-05-20

申请号：AU4745796

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：AU4745796A

公开(公告)日：1996-08-14

申请号：AU4745796

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.