公开(公告)号：DK0805812T3

公开(公告)日：2001-09-17

申请号：DK96903364

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： BASHA FATIMA Z ,  TIETJE KARIN R ,  MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  PRATT JOHN K ,  YAMAMOTO DIANE M ,  SIPPY KEVIN B

IPC: A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  C07D487/02 ,  C07D487/00 ,  C07D495/02

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：AT194141T

公开(公告)日：2000-07-15

申请号：AT96903340

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：GR3034485T3

公开(公告)日：2000-12-29

申请号：GR20000402174

申请日：2000-09-26

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：AU705283B2

公开(公告)日：1999-05-20

申请号：AU4745796

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：AU4745796A

公开(公告)日：1996-08-14

申请号：AU4745796

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：PT808318E

公开(公告)日：2000-12-29

申请号：PT96903340

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： BASHA FATIMA Z ,  ALTENBACH ROBERT J ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F ,  WENDT MICHAEL D ,  MEYER MICHAEL D ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：MX9705675A

公开(公告)日：1997-10-31

申请号：MX9705675

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA J ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  PRATY JOHN K

IPC: A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  C07D487/02 ,  C07D495/02 ,  C07D487/00 ,  C07D239/00 ,  C07D209/00 ,  C07D333/00

Abstract: La presente invencion se refiere a un compuesto de la Formula (I), y a las sales farmacéuticamente aceptables del mismo, en donde W es un sistema de anillo heterocíclico bicíclico. Los compuestos son antagonistas adrenérgicos alfa-1, y son utiles en el tratamiento de hiperplasia prostática benigna; también se describen composiciones antagonistas de alfa-1, y un método para antagonizar receptores de alfa-1, y para el tratamiento de hiperplasia prostática benigna.

公开(公告)号：GR3036560T3

公开(公告)日：2001-12-31

申请号：GR20010401414

申请日：2001-09-06

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  PRATT JOHN K ,  SIPPY KEVIN B ,  TIETJE KARIN R ,  YAMAMOTO DIANE M

IPC: C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D487/02 ,  C07D495/02 ,  C07D487/00

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：DK0808318T3

公开(公告)日：2000-10-16

申请号：DK96903340

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： SIPPY KEVIN B ,  MEYER MICHAEL D ,  ALTENBACH ROBERT J ,  BASHA FATIMA Z ,  CARROLL WILLIAM A ,  DRIZIN IRENE ,  KERWIN JAMES F JR ,  LEBOLD SUZANNE A ,  LEE EDMUND L ,  ELMORE STEVEN W ,  TIETJE KARIN R ,  WENDT MICHAEL D ,  YAMAMOTO DIANE M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  A61K31/395 ,  C07D487/16

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：CA2211212A1

公开(公告)日：1996-08-01

申请号：CA2211212

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER MICHAEL D ,  LEE EDMUND L ,  CARROLL WILLIAM A ,  LEBOLD SUZANNE A ,  WENDT MICHAEL D ,  KERWIN JAMES F JR ,  YAMAMOTO DIANE M ,  DRIZIN IRENE ,  ALTENBACH ROBERT J ,  SIPPY KEVIN B ,  ELMORE STEVEN W ,  TIETJE KARIN R ,  BASHA FATIMA Z

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  A61K31/505

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.