公开(公告)号：WO9834917A3

公开(公告)日：1999-01-14

申请号：PCT/US9802439

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： LEANNA M ROBERT ,  HANNICK STEVEN M ,  RASMUSSEN MICHAEL ,  TIEN JIEN-HEH J ,  BHAGAVATULA LAKSHMI ,  SINGAM PULLA REDDY ,  GATES BRADLEY D ,  KOLACZKOWSKI LAWRENCE ,  PATEL RAMESH R ,  WAYNE GREG ,  LANNOYE GREG ,  ZHANG WEIJIANG ,  TIAN ZHENPING ,  LUKIN KIRILL L ,  NARAYANAN BIKSHANDARKOR A ,  RILEY DAVID A ,  MORTON HOWARD ,  CHANG SOU-JEN

IPC: C12P7/62 ,  A61K31/52 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  C07C69/16 ,  C07C309/73 ,  C07D473/18 ,  C07D473/40 ,  C07D73/00

CPC classification number: C07D473/18

Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

公开(公告)号：DE683167T1

公开(公告)日：1996-11-07

申请号：DE95103186

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  SPANTON STEPHEN G ,  HENRY RODGER F

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.

公开(公告)号：AT182592T

公开(公告)日：1999-08-15

申请号：AT95103186

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  SPANTON STEPHEN G ,  HENRY RODGER F

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.

公开(公告)号：DE69510999T2

公开(公告)日：2000-02-17

申请号：DE69510999

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  SPANTON STEPHEN G ,  HENRY RODGER F

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.

公开(公告)号：DK0683167T3

公开(公告)日：2000-02-07

申请号：DK95103186

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  SPANTON STEPHEN G ,  HENRY RODGER F

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.

公开(公告)号：ES2093579T1

公开(公告)日：1997-01-01

申请号：ES95103186

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  SPANTON STEPHEN G ,  HENRY RODGER F

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.

公开(公告)号：CA2143974A1

公开(公告)日：1995-11-21

申请号：CA2143974

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  HENRY RODGER F ,  SPANTON STEPHEN G

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.

公开(公告)号：DE69510999D1

公开(公告)日：1999-09-02

申请号：DE69510999

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  SPANTON STEPHEN G ,  HENRY RODGER F

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.

公开(公告)号：HK1012629A1

公开(公告)日：1999-08-06

申请号：HK98113964

申请日：1998-12-17

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  SPANTON STEPHEN G ,  HENRY RODGER F

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12 ,  C07D ,  A61K

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms of terazosin monohydrochloride.

公开(公告)号：CA2143974C

公开(公告)日：1997-06-03

申请号：CA2143974

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： MORLEY JAMES A ,  BAUER JOHN F ,  PATEL RAMESH R ,  HENRY RODGER F ,  SPANTON STEPHEN G

IPC: A61K31/505 ,  A61P9/12 ,  C07B63/00 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation.Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms ofterazosin monohydrochloride.