公开(公告)号：WO9834917A3

公开(公告)日：1999-01-14

申请号：PCT/US9802439

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： LEANNA M ROBERT ,  HANNICK STEVEN M ,  RASMUSSEN MICHAEL ,  TIEN JIEN-HEH J ,  BHAGAVATULA LAKSHMI ,  SINGAM PULLA REDDY ,  GATES BRADLEY D ,  KOLACZKOWSKI LAWRENCE ,  PATEL RAMESH R ,  WAYNE GREG ,  LANNOYE GREG ,  ZHANG WEIJIANG ,  TIAN ZHENPING ,  LUKIN KIRILL L ,  NARAYANAN BIKSHANDARKOR A ,  RILEY DAVID A ,  MORTON HOWARD ,  CHANG SOU-JEN

IPC: C12P7/62 ,  A61K31/52 ,  A61P31/12 ,  A61P31/18 ,  A61P31/22 ,  C07C69/16 ,  C07C309/73 ,  C07D473/18 ,  C07D473/40 ,  C07D73/00

CPC classification number: C07D473/18

Abstract: Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.

公开(公告)号：AT480541T

公开(公告)日：2010-09-15

申请号：AT05770762

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： WAYNE GREG ,  MELLICAN SEAN ,  ZHANG GEOFF ,  WILLCOX DAVID ,  BRETING JEFFREY

IPC: C07D487/04

Abstract: The present invention relates to the salt (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate and to methods of preparing the salt.

公开(公告)号：ES2350239T3

公开(公告)日：2011-01-20

申请号：ES05770762

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BRETING JEFFREY ,  MELLICAN SEAN ,  ZHANG GEOFF ,  WILLCOX DAVID ,  WAYNE GREG

IPC: C07D487/04

Abstract: Bencenosulfonato de (1S,5S)-3-(5,6-dicloropiridin-3-il)-3,6diazabiciclo[3.2.0]heptano cristalino demostrando al menos un pico característico en el modelo de difracción de rayos X de polvo, a valores de 2 theta de 8'8 ± 0'2, 11'8, 13'7, 15'1, 17'2, 18'5, 18'9, 20'6, 24'4, 24'7, y 27'4 ± 0'2.