公开(公告)号：WO2004032908A9

公开(公告)日：2004-05-27

申请号：PCT/US0331220

申请日：2003-10-02

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  DINGES JUERGEN ,  SAUER DARYL R ,  HENKIN JACK

IPC: A61K31/455 ,  C07D213/82 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  A61K31/00

CPC classification number: C07D213/82 ,  A61K31/455 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04

Abstract: Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.

Abstract translation: 具有下式的化合物是血管生成抑制剂。 还公开了含有该化合物的组合物，制备该化合物的方法以及使用该化合物的治疗方法。

公开(公告)号：WO2004032908A3

公开(公告)日：2004-08-12

申请号：PCT/US0331220

申请日：2003-10-02

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  DINGES JUERGEN ,  SAUER DARYL R ,  HENKIN JACK

IPC: A61K31/455 ,  C07D213/82 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04

CPC classification number: C07D213/82 ,  A61K31/455 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04

Abstract: Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.

Abstract translation: 具有下式的化合物是血管发生抑制剂。 还公开了含有化合物的组合物，制备化合物的方法和使用该化合物的治疗方法。

公开(公告)号：DK1318978T3

公开(公告)日：2006-06-06

申请号：DK01971244

申请日：2001-09-20

Applicant: ABBOTT LAB

Inventor： WANG XILU ,  AUGERI DAVID J ,  DICKMAN DANIEL A ,  DINGES JUERGEN ,  FESIK STEPHEN W ,  ROSENBERG SAUL H ,  SHEN WANG ,  THOMAS SHEELA A ,  WENDT MICHAEL D ,  MCCLELLAN WILLIAM ,  OOST THORSTEN ,  BRUNCKO MILAN ,  BAUMEISTER STEVEN A ,  DING HONG ,  HAJDUK PHILIP J ,  KUNZER AARON R ,  NETTESHEIM DAVID G ,  PETROS ANDREW M

IPC: C07C311/51 ,  A61K31/18 ,  A61K31/428 ,  A61K31/63 ,  A61K31/635 ,  A61P9/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  C07C311/46 ,  C07C317/28 ,  C07C323/12 ,  C07C323/17 ,  C07C323/25 ,  C07C323/30 ,  C07C323/37 ,  C07C323/43 ,  C07C323/44 ,  C07C323/48 ,  C07C323/58 ,  C07C323/60 ,  C07D203/10 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D207/24 ,  C07D207/40 ,  C07D207/404 ,  C07D209/08 ,  C07D209/52 ,  C07D209/54 ,  C07D209/96 ,  C07D211/14 ,  C07D211/44 ,  C07D211/70 ,  C07D211/74 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/71 ,  C07D215/14 ,  C07D215/22 ,  C07D215/227 ,  C07D215/38 ,  C07D215/48 ,  C07D217/04 ,  C07D221/20 ,  C07D231/12 ,  C07D233/60 ,  C07D235/08 ,  C07D235/26 ,  C07D241/08 ,  C07D241/16 ,  C07D249/04 ,  C07D263/32 ,  C07D263/56 ,  C07D263/58 ,  C07D277/62 ,  C07D277/64 ,  C07D295/13 ,  C07D295/14 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D307/14 ,  C07D317/54 ,  C07D333/28 ,  C07D333/68 ,  C07D333/70 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D417/12 ,  C07D451/02 ,  C07D491/107

公开(公告)号：CA2501043A1

公开(公告)日：2004-04-22

申请号：CA2501043

申请日：2003-10-02

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  DINGES JUERGEN ,  SAUER DARYL R ,  HENKIN JACK

IPC: A61K31/455 ,  C07D213/82 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04

Abstract: Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.

公开(公告)号：CA2560691A1

公开(公告)日：2005-10-13

申请号：CA2560691

申请日：2005-03-24

Applicant: MAKOTO AOYAMA ,  ABBOTT LAB

Inventor： WADA CAROL K ,  STEINMAN DOUGLAS H ,  RAFFERTY PAUL ,  MAKOTO AOYAMA ,  XIA ZHIREN ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  DINGES JUERGEN ,  HOLMS JAMES H ,  ZHANG HENRY Q ,  AKRITOPOULOU-ZANZE IRINI ,  DIXON RICHARD W ,  DJURIC STEVAN W ,  ERICSSON ANNA M ,  FISCHER KIMBA ,  GRACIAS VIJAYA J ,  ARNOLD LEE D ,  GASIECKI ALAN F

IPC: C07D409/04 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00 ,  A61P37/00 ,  C07D231/54 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07D495/04

Abstract: Compounds of the present invention are useful for inhibiting protein tyrosin e kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：CA2481240A1

公开(公告)日：2003-10-23

申请号：CA2481240

申请日：2003-04-03

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  KOLACZKOWSKI LAWRENCE ,  DINGES JUERGEN ,  SAUER DARYL R ,  PARK DAVID C ,  HENKIN JACK ,  BRADLEY MICHAEL F ,  VASUDEVAN ANIL

IPC: C07D241/24 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/4747 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/551 ,  A61P1/00 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P15/00 ,  A61P17/00 ,  A61P27/02 ,  A61P35/00 ,  C07D213/81 ,  C07D213/82 ,  C07D239/28 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D491/10 ,  C07D491/113

Abstract: Compounds having the formula (I) are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds. A is selected from the group consisting of pyridine, pyridine N-oxide, pyridazine, pyrimidine. pyrazine, and triazine; R1 and R2, together with the nitrogen atom to which they are attached, form a five - to eight - membered ring containing an additional ze ro to two heteroatoms selected from the group consisting of nitrogen, oxygen, a nd sulfur; wherein the ring can be optionally substituted with one, two, or thr ee substituents independently selected from the group consisting of alkoxyalkyl , alkoxycarbonyl, alkyl, unsubstituted alkylcarbonyl, amino, aminocarbonyl, aryl, arylalkoxycarbonyl, wylalkyl, carboxy, formyl, haloalkyl, heterocycle, (heterocycle)alkyl, hydroxy, hydroxyalkoxyalkyl, hydroxyalkyl, and spiroheterocycle; R3 at each occurance is independently selected from the group consisting 'of alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, unsubstituted alkylcarbonyl, alkylsulfanyl, amino, aminocarbonyl, aryl, arylalkyl, aryloxy, cyano, cyanoalkyl, cyanoalkyl, (cycloalkyl)alkyl, halo, haloalkyl, heterocycle, hydroxy, hydroxyalkyl, and nitro; X is selected from the group consisting of O, S, and CH2; and m is 0-4.

公开(公告)号：UY34177A

公开(公告)日：2013-01-31

申请号：UY34177

申请日：2012-06-29

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： MICHAEL OCHSE ,  KARLA DRESCHER ,  BERTHOLD BEHL ,  DINGES JUERGEN ,  CLARISSA JAKOB ,  GENESTE HERVE ,  LOIC LAPLANCHE

IPC: A61K31/4353 ,  A61P25/00 ,  C07D471/04

Abstract: Nuevos compuestos de carboxamida. Composiciones farmacéuticas que los contienen. Su uso en la terapia. Estos compuestos presentan propiedades terapéuticas valiosas y son particularmente apropiados para tratar o controlar diversos trastornos neurológicos y psiquiátricos, para mejorar sus síntomas y para reducir el riesgo de que se desarrollen.