公开(公告)号：WO2007100990A2

公开(公告)日：2007-09-07

申请号：PCT/US2007062329

申请日：2007-02-16

Applicant: ABBOTT LAB ,  COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G Z ,  SHEIKH AHMAD Y ,  LOU XIAOCHUN ,  HENRY RODGER F ,  BARNES DAVID M ,  KOLACZKOWSKI LAWRENCE ,  HAIGHT ANTHONY R ,  CHANG SOU-JEN ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G

Inventor： COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G Z ,  SHEIKH AHMAD Y ,  LOU XIAOCHUN ,  HENRY RODGER F ,  BARNES DAVID M ,  KOLACZKOWSKI LAWRENCE ,  HAIGHT ANTHONY R ,  CHANG SOU-JEN ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G

IPC: C07D487/04 ,  A61K31/407

CPC classification number: C07D487/04

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

Abstract translation: 八氢吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体预防或改善的病症或病症。 八氢吡咯并[3,4-b]吡咯化合物，使用这些化合物的方法，制备它们的组合物和制备这些化合物的方法在本文中公开。

公开(公告)号：BR112012031469A2

公开(公告)日：2016-11-01

申请号：BR112012031469

申请日：2011-06-08

Applicant: ABBOTT LAB

Inventor： SHEIKH AHMAD Y ,  ZHANG GEOFF G Z ,  BRACKEMEYER PAUL J

IPC: C07D495/04 ,  A61K31/4365 ,  A61P35/00

Abstract: formas cristalinas de inibidores de quinase. a presente invenção se refere a uma base livre de n-(4-{4-amino-7-[1-(2-hidroxietil)-1h-pirazol-4-il]tieno[3,2-c]piridin-3-il}fenil)-n -(3-fluorofenil) ureia e as formas cristalinas da mesma que são ingredientes farmacêuticos adequados para composições farmacêuticas uteis úteis no tratamento de doença, por exemplo, cãncer.

公开(公告)号：MY149513A

公开(公告)日：2013-09-13

申请号：MYPI20083158

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  HENRY RODGER F ,  BARNES DAVID M ,  LAWRENCE KOLACZKOWSKI ,  HAIGHT ANTHONY R ,  SOU-JEN CHANG ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G ,  CHEN ZHAO ,  MINGHUA SUN ,  BLACK LAWRENCE A ,  ZHU ZHENG GUO ,  GREGG ROBERT J ,  ZHANG GEOFF G Z ,  SHEIKH AHMAD Y ,  XIAOCHUN LOU

IPC: A61K31/407

Abstract: OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES ARE USEFUL IN TREATING CONDITIONS OR DISORDERS PREVENTED BY OR AMELIORATED BY HISTAMINE-3 RECEPTOR LIGANDS. OCTAHYDRO PYRROLO[3,4-B]PYRROLE COMPOUNDS, METHODS FOR USING SUCH COMPOUNDS, COMPOSITIONS FOR MAKING THEM, AND PROCESSES FOR PREPARING SUCH COMPOUNDS ARE DISCLOSED HEREIN.

公开(公告)号：CA2802064A1

公开(公告)日：2011-12-15

申请号：CA2802064

申请日：2011-06-08

Applicant: ABBOTT LAB

Inventor： ZHANG GEOFF G Z ,  BRACKEMEYER PAUL J ,  SHEIKH AHMAD Y

IPC: C07D495/04 ,  A61K31/4365 ,  A61P35/00

Abstract: N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N'-(3-fluorophenyl)urea free base and crystallines form thereof are suitable pharmaceutical ingredients for pharmaceutical compositions useful in the treatment of disease, for example, cancer.

公开(公告)号：UA97639C2

公开(公告)日：2012-03-12

申请号：UAA200811465

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G Z ,  SHEIKH AHMAD Y ,  LOU XIAOCHUN ,  HENRY RODGER F ,  BARNES DAVID M ,  KOLACZKOWSKI LAWRENCE ,  HAIGHT ANTHONY R ,  CHANG SOU-JEN ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G

IPC: C07D487/04 ,  A61K31/407

Abstract: Раскрытыоктагидропирроло[3,4-b]пиррольныепроизводныеформулы I и II, пригодныедлялечениясостоянийилирасстройств, которыепредотвращаютсяилиоблегчаютсяс помощьюлигандоврецепторагистамина-3.Раскрытыоктагидропирроло[3,4-b]пиррольныесоединения, применениетакихсоединений, композиции, содержащиеэтисоединения, испособыполучениятакихсоединений.

公开(公告)号：AU2007220889A1

公开(公告)日：2007-09-07

申请号：AU2007220889

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： FICKES MICHAEL G ,  SUN MINGHUA ,  ZHAO CHEN ,  SHEIKH AHMAD Y ,  HENRY RODGER F ,  BARNES DAVID M ,  GREGG ROBERT J ,  HAIGHT ANTHONY R ,  KOLACZKOWSKI LAWRENCE ,  WITTENBERGER STEVEN J ,  ZHANG GEOFF G Z ,  COWART MARLON D ,  LOU XIAOCHUN ,  ZHENG GUO ZHU ,  BLACK LAWRENCE A ,  CHANG SOU-JEN

IPC: C07D487/04 ,  A61K31/407

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

公开(公告)号：SG188878A1

公开(公告)日：2013-04-30

申请号：SG2013017603

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G Z ,  SHEIKH AHMAD Y ,  LOU XIAOCHUN ,  HENRY RODGER F ,  BARNES DAVID M ,  KOLACZKOWSKI LAWRENCE ,  HAIGHT ANTHONY R ,  CHANG SOU-JEN ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.Figure 1

公开(公告)号：CA2802042A1

公开(公告)日：2011-12-15

申请号：CA2802042

申请日：2011-06-08

Applicant: ABBOTT LAB

Inventor： ZHANG GEOFF G Z ,  BRACKEMEYER PAUL J ,  SHEIKH AHMAD Y

IPC: C07D495/04 ,  A61K31/4365 ,  A61P35/00

Abstract: Salts of N-(4- {4-amino-7-[ 1 -(2-hydroxyethyl)- 1 H-pyrazol-4-yl]thieno[3,2-c]pyridin- 3-yl}phenyl)-N'-(3-fluorophenyl)urea and crystalline forms thereof are suitable pharmaceutical ingredients for pharmaceutical compositions useful in the treatment of disease, for example, cancer.

公开(公告)号：SG170033A1

公开(公告)日：2011-04-29

申请号：SG2011013430

申请日：2007-02-16

Applicant: ABBOTT LAB

Inventor： COWART MARLON D ,  ZHAO CHEN ,  SUN MINGHUA ,  BLACK LAWRENCE A ,  ZHENG GUO ZHU ,  GREGG ROBERT J ,  ZHANG GEOFF G Z ,  SHEIKH AHMAD Y ,  LOU XIAOCHUN ,  HENRY RODGER F ,  BARNES DAVID M ,  KOLACZKOWSKI LAWRENCE ,  HAIGHT ANTHONY R ,  CHANG SOU-JEN ,  WITTENBERGER STEVEN J ,  FICKES MICHAEL G

Abstract: OCTAHYDRO-PYRROLO[3,4-B] PYRROLE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR LIGANDS Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

公开(公告)号：AR083722A1

公开(公告)日：2013-03-20

申请号：ARP110101991

申请日：2011-06-09

Applicant: ABBOTT LAB

Inventor： ZHANG GEOFF G Z ,  BRACKEMEYER PAUL J ,  SHEIKH AHMAD Y

IPC: C07D495/04 ,  A61K31/4365 ,  A61P35/00

Abstract: N-(4-{4-amino-7-[1-(2-hidroxietil)-1H-pirazol-4-il]tieno[3,2-c]piridin-3-il}fenil)-N’-(3-fluorofenil)urea como base libre y formas cristalinas de la misma que son ingredientes farmacéuticos apropiados para hacer composiciones farmacéuticas útiles para el tratamiento de enfermedades, por ejemplo, cáncer. Proceso de obtención, composiciones farmacéuticas.Reivindicación 1: El compuesto N-(4-{4-amino-7-[1-(2-hidroxietil)-1H-pirazol-4-il]tieno[3,2-c]piridin-3-il}fenil)-N’-(3-fluorofenil)urea en una forma cristalina sólida, caracterizado porque la forma cristalina es la Forma I de la base libre, caracterizada por lo menos por un pico de difracción de rayos X en polvo en una o más cualesquiera de las siguientes posiciones: 7,20, 8,37, 11,38, 16,75, 16,95, 19,60, 22,04, y 22,86º 2q, ± 0,2º 2q. Reivindicación 13: El compuesto N-(4-{4-amino-7-[1-(2-hidroxietil)-1H-pirazol-4-il]tieno[3,2-c]piridin-3-il}fenil)-N’-(3-fluorofenil)urea en una forma cristalina sólida, caracterizado porque la forma cristalina es la base libre en la Forma II, caracterizada por lo menos por un pico de difracción de rayos X en polvo en una o más cualesquiera de las siguientes posiciones: 7,30, 8,81, 11,32, 15,08, 16,79, 19,46, 22,22, 22,70, 23,37, 24,29, 24,61, 25,07º 2q, ±@@@0,2º 2q.