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公开(公告)号：CO7061082A2
公开(公告)日：2014-09-19
申请号：CO14198817
申请日：2014-09-09
Applicant: PTC THERAPEUTICS INC , HOFFMANN LA ROCHE
Inventor： QI HONGYAN , CHOI SOONGYU , DAKKA AMAL , KARP GARY MITCHELL , NARASIMHAN JANA , NARYSHKIN NIKOLAI , TURPOFF ANTHONY A , WEETALL MARIA L , WELCH ELLEN , WOLL MATTHEW , YANG TIANLE , ZHANG XIAOYAN , ZHANG NANJING , ZHAO XIN , GREEN LUKE , PINARD EMMANUEL , RATNI HASANE
IPC: A61K31/53
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公开(公告)号：HUE039779T2
公开(公告)日：2019-02-28
申请号：HUE13747100
申请日：2013-02-08
Applicant: PTC THERAPEUTICS INC , HOFFMANN LA ROCHE
Inventor： QI HONGYAN , CHOI SOONGYU , DAKKA AMAL , KARP GARY , NARASIMHAN JANA , NARYSHKIN NIKOLAI , TURPOFF ANTHONY , WEETALL MARLA , WELCH ELLEN , WOLL MATTHEW , YANG TIANLE , ZHANG NANJING , ZHANG XIAOYAN , ZHAO XIN , GREEN LUKE , PINARD EMMANUEL , RATNI HASANE
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公开(公告)号：CA2913785A1
公开(公告)日：2014-12-31
申请号：CA2913785
申请日：2014-06-23
Applicant: HOFFMANN LA ROCHE , PTC THERAPEUTICS INC
Inventor： DAKKA AMAL , GREEN LUKE , KARP GARY , NARASIMHAN JANA , NARYSHKIN NIKOLAI , PINARD EMMANUEL , QI HONGYAN , RATNI HASANE , RISHER NICOLE , WEETALL MARIA , WOLL MATTHEW
IPC: A61K31/497 , A61K31/423 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/4985 , A61P21/00
Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
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公开(公告)号：WO2014209841A2
公开(公告)日：2014-12-31
申请号：PCT/US2014043577
申请日：2014-06-23
Applicant: HOFFMANN LA ROCHE , HOFFMANN LA ROCHE , PTC THERAPEUTICS INC
Inventor： DAKKA AMAL , GREEN LUKE , KARP GARY , NARASIMHAN JANA , NARYSHKIN NIKOLAI , PINARD EMMANUEL , QI HONGYAN , RATNI HASANE , RISHER NICOLE , WEETALL MARLA , WOLL MATTHEW
IPC: A61K31/4985
CPC classification number: C07D519/00 , C07D263/56 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/10
Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
Abstract translation: 本发明提供其中A，B，X，Y，R 1和R 2如本文所述的式（I）化合物及其药学上可接受的盐。 此外，本发明涉及制备式（I）化合物，包含它们的药物组合物及其作为药物的用途。
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公开(公告)号：AU2022320725A1
公开(公告)日：2024-02-22
申请号：AU2022320725
申请日：2022-07-29
Applicant: PTC THERAPEUTICS INC
Inventor： BABU SURESH , ALAM RAUFUL , BHATTACHARYYA ANURADHA , CHEN GUANGMING , EASTWOOD MATTHEW , HOSSEYNI SEYEDMORTEZA , JIANG YAO , KARP GARY , MOON YOUNG-CHOON , NARASIMHAN JANA , REN HONGYU , SYDORENKO NADIYA , WOLL MATTHEW , ZHANG NANJING
IPC: C07D487/04 , A61K31/5025 , A61P25/14 , A61P25/28
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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Patent Agency Ranking
公开(公告)号：HK1215399A1
公开(公告)日：2016-08-26
申请号：HK16103480
申请日：2016-03-24
Applicant: HOFFMANN LA ROCHE , PTC THERAPEUTICS INC
Inventor： DAKKA AMAL , GREEN LUKE , KARP GARY , NARASIMHAN JANA , NARYSHKIN NIKOLAI , PINARD EMMANUEL , QI HONGYAN , RATNI HASANE , RISHER NICOLE , WEETALL MARLA , WOLL MATTHEW
IPC: C07D20060101 , A61K20060101
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公开(公告)号：SG11202012869SA
公开(公告)日：2021-01-28
申请号：SG11202012869S
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC
Inventor： ZHANG NANJING , BABU SURESH , BARRAZA SCOTT J , BHATTACHARYYA ANURADHA , CHEN GUANGMING , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , SYDORENKO NADIYA , TURPOFF ANTHONY , WOLL MATTHEW , YAN WUMING
IPC: C07D417/14 , A61K31/4439 , A61K31/454 , A61K31/46 , A61K31/496 , A61K31/5025 , A61K31/519 , A61K31/55 , A61P25/00 , A61P25/14 , A61P25/28 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：CA2913785C
公开(公告)日：2021-08-31
申请号：CA2913785
申请日：2014-06-23
Applicant: HOFFMANN LA ROCHE , PTC THERAPEUTICS INC
Inventor： DAKKA AMAL , GREEN LUKE , KARP GARY , NARASIMHAN JANA , NARYSHKIN NIKOLAI , PINARD EMMANUEL , QI HONGYAN , RATNI HASANE , RISHER NICOLE , WEETALL MARIA , WOLL MATTHEW
IPC: C07D471/04 , A61K31/423 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/4985 , A61P21/00 , C07D263/56 , C07D413/12 , C07D487/04 , C07D519/00
Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, Rl and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of spinal muscular atrophy (SMA).
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公开(公告)号：SG11201911615WA
公开(公告)日：2020-01-30
申请号：SG11201911615W
申请日：2018-06-05
Applicant: PTC THERAPEUTICS INC
Inventor： WOLL MATTHEW , AMEDZO LUKIANA , BABU SURESH , BARRAZA SCOTT , BHATTACHARYYA ANURADHA , KARP GARY , MAZZOTTI ANTHONY , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , XU ZHENRONG
IPC: C07D239/74 , C07D239/94 , C07D239/95
Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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公开(公告)号：EP3013345A4
公开(公告)日：2016-11-30
申请号：EP14816651
申请日：2014-06-23
Applicant: HOFFMANN LA ROCHE , PTC THERAPEUTICS INC
Inventor： DAKKA AMAL , GREEN LUKE , KARP GARY , NARASIMHAN JANA , NARYSHKIN NIKOLAI , PINARD EMMANUEL , QI HONGYAN , RATNI HASANE , RISHER NICOLE , WEETALL MARLA , WOLL MATTHEW
IPC: A61K31/497 , A61K31/4965 , C07D401/00
CPC classification number: C07D519/00 , C07D263/56 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/10
Abstract: The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
Abstract translation: 本发明提供其中A，B，X，Y，R 1和R 2如本文所述的式（I）化合物及其药学上可接受的盐。 此外，本发明涉及制备式（I）化合物，包含它们的药物组合物及其作为药物的用途。
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