公开(公告)号：ZA200705116B

公开(公告)日：2008-06-25

申请号：ZA200705116

申请日：2007-06-18

Applicant: VERTEX PHARMA

Inventor： IOANA DRUTU ,  BANDARAGE UPUL K ,  CHARIFSON PAUL S ,  MIGUEL GARCIA-GUZMAN BLANCO ,  AKIKO NAKATANI ,  HURLEY DENNIS J ,  BERGERON DANIELE M ,  DAVIES ROBERT J ,  MAKINGS LEWIS R ,  GABRIEL RAFFAI

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：ZA200602449B

公开(公告)日：2007-05-30

申请号：ZA200602449

申请日：2006-03-24

Applicant: VERTEX PHARMA

Inventor： MIGUEL GARCIA-GUZMAN BLANCO ,  GROOTENHUIS PETER D J ,  AKIKO NAKATANI ,  DANIEL DISEPIO ,  DANIELE BERGERON ,  JAMES HURLEY DENNIS ,  MAKINGS LEWIS R ,  GABRIEL RAFFAI

IPC: A61K20090101 ,  A61K31/495 ,  A61K31/496 ,  A61P20090101 ,  C07D20090101 ,  C07D295/02 ,  C07D295/033 ,  C07D295/073 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D309/14 ,  C07D451/02 ,  C07D451/04 ,  C07D493/08

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：AU2005309365B2

公开(公告)日：2011-10-06

申请号：AU2005309365

申请日：2005-11-29

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT J ,  GABRIEL RAFFAI ,  AKIKO NAKATANI ,  MAKINGS LEWIS R ,  IOANA DRUTU ,  BANDARAGE UPUL K ,  CHARIFSON PAUL S ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  BERGERON DANIELE M

IPC: C07D471/00 ,  A61K31/435 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4747 ,  A61P1/00 ,  A61P3/04 ,  A61P9/00 ,  A61P17/02 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：ZA200807236B

公开(公告)日：2009-08-26

申请号：ZA200807236

申请日：2008-08-21

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  IOANA DRUTU ,  GABRIEL RAFFAI ,  BERGERON DANIELE M ,  AKIKO NAKATANI ,  TERMIN ANDREAS P ,  ALINA SILINA

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

公开(公告)号：ZA200806028B

公开(公告)日：2009-04-29

申请号：ZA200806028

申请日：2008-07-10

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  MIGUEL GARCIA-GUZMAN BLANCO ,  HURLEY DENNIS J ,  IOANA DRUTU ,  GABRIEL RAFFAI ,  BERGERON DANIELE M ,  AKIKO NAKATANI ,  TERMIN ANDREAS P ,  ALINA SILINA

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：ZA200701397B

公开(公告)日：2009-04-29

申请号：ZA200701397

申请日：2007-02-16

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  HURLEY DENIS J ,  GABRIEL RAFFAI ,  AKIKO NAKATANI ,  ALINA SILINA ,  MIGUEL GARCIA-GUZMAN BLANCO ,  LOANA DRUTU ,  BERGERON DANIELE M ,  TERMIN ANDREAS P

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith or treating muscarinic receptor mediated diseases.