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公开(公告)号：AU2020286424A1
公开(公告)日：2022-01-06
申请号：AU2020286424
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：BR112021022832A2
公开(公告)日：2022-01-18
申请号：BR112021022832
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM , MEDEK ALES , AMY BETH HALL , MAXWELL BRAD , CAVAN MCKEON BLIGH , DENNIS JAMES HURLEY , BOUCHER DIANE , GABRIELLE SIMONE FLEMING , XU JINWANG , JOHN PATRICK MAXWELL , STAVROPOULOS KATHY , KEVIN JAMES GAGNON , KEVIN MICHAEL COTTRELL , KIRK ALAN OVERHOFF , LEV TYLER DEWEY FANNING , MAC ARTHUR JOHNSON JR , ZAKY MARIAM , SPOSATO MARISA , LAI MEI-HSIU , MICHAEL AARON BRODNEY , MICHAEL JOHN BOYD , MICHAEL PHILIP CLARK , SHRESTHA MUNA , PEDRO MANUEL GARCIA BARRANTES , JONES PETER , PHILIPPE MARCEL NUHANT , TANG QING , REBECCA JANE SWETT , ROBERT DANIEL GIACOMETTI , ROBERT FRANCIS FIMOGNARI , RONALD LEE GREY JR , SAWANT RUPA , GUIDO SAMANTHA , SARAH CAROL HOOD , KESAVAN SARATHY , RODAY SETU , GIROUX SIMON , LIU SIYING , ROEPER STEFANIE , THOMSON STEPHEN , STEVEN M RONKIN , TIMOTHY LEWIS TAPLEY , UPUL KEERTHI BANDARAGE , DAMAGNEZ VERONIQUE , SHI YI
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: pirrois tricíclicos condensados como moduladores da alfa-1 antitripsina. a divulgação fornece compostos úteis para tratar a deficiência de alfa-1 antitripsina (aatd), de acordo com a fórmula (i), seus tautômeros, sais farmaceuticamente aceitáveis dos compostos, sais farmaceuticamente aceitáveis dos tautômeros, derivados deuterados dos compostos, derivados deuterados dos tautômeros e derivados deuterados dos sais, formas sólidas desses compostos e processos para produzir esses compostos.
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公开(公告)号：MX2023005589A
公开(公告)日：2023-07-31
申请号：MX2023005589
申请日：2021-11-17
Applicant: VERTEX PHARMA
Inventor： SHI YI , GIROUX SIMON , MEDEK ALES , RODAY SETU , SAWANT RUPA , LAI MEI-HSIU , LIU SIYING , OVERHOFF KIRK ALAN , SPOSATO MARISA , HU KAN-NIAN , SONG ZHENGTIAN , TORRICO GUZMAN ELISA A , SOKOLOWSKY KATHLEEN PAIGE
IPC: A61P1/16 , A61K31/416 , A61K31/4162 , A61P11/00 , C07D487/04
Abstract: Formas sólidas del ácido 4-(5-(4-fluorofenil)-6- (tetrahidro-2H-piran-4-il)-1,5-dihidropirrolo[2,3-f]indazol-7-il) benzoico (Compuesto 1) capaces de modular la actividad de la alfa-1 antitripsina (AAT) y métodos para tratar la deficiencia de alfa-1 antitripsina (AATD) al administrar una o más de estas formas, y métodos de uso y preparación de las mismas para el tratamiento de la deficiencia de la alfa-1 antitripsina (AATD).
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公开(公告)号：JOP20210301A1
公开(公告)日：2023-01-30
申请号：JOP20210301
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： SHI YI , TAPLEY TIMOTHY LEWIS , SWETT REBECCA JANE , XU JINWANG , MAXWELL JOHN PATRICK , SHRESTHA MUNA , OVERHOFF KIRK ALAN , BANDARAGE UPUL KEERTHI , BRODNEY MICHAEL AARON , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , TANG QING , THOMSON STEPHEN , GAGNON KEVIN JAMES , GREY JR RONALD LEE , JONES PETER , JOHNSON JR MAC ARTHUR , GUIDO SAMANTHA , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , DAMAGNEZ VERONIQUE , RODAY SETU , RONKIN STEVEN M , ROEPER STEFANIE , ZAKY MARIAM , SAWANT RUPA , SPOSATO MARISA , STAVROPOULOS KATHY , GARCIA BARRANTES PEDRO MANUEL , FANNING LEV TYLER DEWEY , FLEMING GABRIELLE SIMONE , FIMOGNARI ROBERT FRANCIS , CLARK MICHAEL PHILIP , COTTRELL KEVIN MICHAEL , KESAVAN SARATHY , LAI MEI-HSIU , LOOKER ADAM , LIU SIYING , MAXWELL BRAD , MEDEK ALES , NUHANT PHILIPPE MARCEL , HOOD SARAH CAROL , HALL AMY BETH , HURLEY DENNIS JAMES
Abstract: يوفرالكشفالحاليمركباتمُفيدةلعلاجنقصمضادتريبسينألفا-1 (AATD)،وفقًاللصيغة (I): (I)،ومماثلاتكيميائيةمنها،وأملاحمقبولةصيدليًامنالمركبات،وأملاحمقبولةصيدليًامنالمماثلاتالكيميائية،ومشتقاتمُعالجةبالديوتريوممنالمركبات،ومشتقاتمعالجةبالديوتريوممنالمماثلاتالكيميائية،ومشتقاتمُعالجةبالديوتريوممنالأملاح،والصورالصلبةمنتلكالمركباتوعملياتتحضيرتلكالمركبات.
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公开(公告)号：MA55971A
公开(公告)日：2022-03-23
申请号：MA55971
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , COTTRELL KEVIN MICHAEL , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM
IPC: A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
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Patent Agency Ranking
公开(公告)号：CA3202071A1
公开(公告)日：2022-05-27
申请号：CA3202071
申请日：2021-11-17
Applicant: VERTEX PHARMA
Inventor： SHI YI , LAI MEI-HSIU , MEDEK ALES , HU KAN-NIAN , SONG ZHENGTIAN , TORRICO GUZMAN ELISA A , SOKOLOWSKY KATHLEEN PAIGE , GIROUX SIMON , LIU SIYING , OVERHOFF KIRK ALAN , RODAY SETU , SAWANT RUPA , SPOSATO MARISA
IPC: A61K31/416 , A61K31/4162 , A61P1/16 , A61P11/00 , C07D487/04
Abstract: Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD).
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公开(公告)号：CO2021016594A2
公开(公告)日：2022-04-29
申请号：CO2021016594
申请日：2021-12-07
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , GAGNON KEVIN JAMES , HOOD SARAH CAROL , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , BANDARAGE UPUL KEERTHI , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , XU JINWANG , COTTRELL KEVIN MICHAEL , SHRESTHA MUNA , BOUCHER DIANE , CLARK MICHAEL PHILIP , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GUIDO SAMANTHA , LAI MEI-HSIU , LIU SIYING , MAXWELL BRAD , OVERHOFF KIRK ALAN , RONKIN STEVEN M , SPOSATO MARISA , STAVROPOULOS KATHY , THOMSON STEPHEN , ZAKY MARIAM
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos.
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公开(公告)号：CR20210608A
公开(公告)日：2022-02-11
申请号：CR20210608
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , GUIDO SAMANTHA , HOOD SARAH CAROL , THOMSON STEPHEN , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , KESAVAN SARATHY , MAXWELL JOHN PATRICK , OVERHOFF KIRK ALAN , STAVROPOULOS KATHY , XU JINWANG , CLARK MICHAEL PHILIP , GAGNON KEVIN JAMES , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , LOOKER ADAM , MEDEK ALES , FLEMING GABRIELLE SIMONE , HURLEY DENNIS JAMES , RONKIN STEVEN M , SHRESTHA MUNA , JONES PETER , BOUCHER DIANE , BRODNEY MICHAEL AARON , GARCIA BARRANTES PEDRO MANUEL , NUHANT PHILIPPE MARCEL , HALL AMY BETH , RODAY SETU , SAWANT RUPA , SPOSATO MARISA , BANDARAGE UPUL KEERTHI , JOHNSON JR MAC ARTHUR , LAI MEI-HSIU , MAXWELL BRAD , SWETT REBECCA JANE , ZAKY MARIAM , COTTRELL KEVIN MICHAEL , GREY JR RONALD LEE , LIU SIYING , ROEPER STEFANIE , TANG QING , TAPLEY TIMOTHY LEWIS , SHI YI
IPC: A61K31/429 , A61K31/4162 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos
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公开(公告)号：CA3140039A1
公开(公告)日：2020-12-10
申请号：CA3140039
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：AU2021381509A1
公开(公告)日：2023-06-22
申请号：AU2021381509
申请日：2021-11-17
Applicant: VERTEX PHARMA
Inventor： SHI YI , LAI MEI-HSIU , MEDEK ALES , HU KAN-NIAN , SONG ZHENGTIAN , TORRICO GUZMAN ELISA , SOKOLOWSKY KATHLEEN , GIROUX SIMON , LIU SIYING , OVERHOFF KIRK , RODAY SETU , SAWANT RUPA , SPOSATO MARISA
IPC: A61P1/16 , A61K31/416 , A61K31/4162 , A61P11/00 , C07D487/04
Abstract: Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD).
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