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公开(公告)号：JP2013253114A
公开(公告)日：2013-12-19
申请号：JP2013196681
申请日：2013-09-24
Applicant: VERTEX PHARMA
Inventor： LEDEBOER MARK W , WANNAMAKER MARION W , FARMER LUC J , WANG TIANSHENG , PIERCE ALBERT C , MARTINEZ-BOTELLA GABRIEL , BETHIEL RANDY S , BEMIS GUY W , WANG JIAN , SALITURO FRANCESCO G , ARNOST MICHAEL J , COME JON H , GREEN JEREMY , STEWART MICHELLE , MARHEFKA CRAIG
IPC: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/55 , A61K31/551 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P15/06 , A61P15/10 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D519/00 , C12N9/99 , C12Q1/48
Abstract: PROBLEM TO BE SOLVED: To provide pyrrolopyridine compounds useful as inhibitors of protein kinase.SOLUTION: The present invention relates to compounds of formula (I) (wherein Q, Z, R, Rand Rare described in specification), useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：WO2005068468A3
公开(公告)日：2005-10-13
申请号：PCT/US2004040422
申请日：2004-12-02
Applicant: VERTEX PHARMA , STRAUB JUDITH , HALE MICHAEL R , MALTAIS FRANCOIS , MARTINEZ-BOTELLA GABRIEL , ARONOV ALEX , BEMIS GUY W
Inventor： STRAUB JUDITH , HALE MICHAEL R , MALTAIS FRANCOIS , MARTINEZ-BOTELLA GABRIEL , ARONOV ALEX , BEMIS GUY W
IPC: A61K31/506 , A61K45/06 , C07D239/48 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D487/08 , A61P35/00
CPC classification number: C07D239/48 , A61K31/506 , A61K45/06 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K2300/00
Abstract: Described herein are compounds that are useful as protein kinase inhibitors of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ring B, Z , Z , U, p, Q, R , R , R , and R are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
Abstract translation: 本文描述了可用作式（I）的蛋白激酶抑制剂或其药学上可接受的盐的化合物，其中环B，Z 1，Z 2，U，p，Q，R 1， R 3，R 3和R 3如本文所定义。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种疾病的严重性，包括中风，炎性疾病，自身免疫性疾病如SLE狼疮和牛皮癣，增殖性疾病如癌症，以及与器官移植相关的病症 。
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公开(公告)号：WO2007041130A3
公开(公告)日：2010-01-21
申请号：PCT/US2006037593
申请日：2006-09-28
Applicant: VERTEX PHARMA , SALITURO FRANCESCO , FARMER LUC , WANG TIANSHENG , WANG JIAN , BETHIEL RANDY , WANNAMAKER MARION , MARTINEZ-BOTELLA GABRIEL , DUFFY JOHN , ARONOV ALEXANDER , LAUFFER DAVID , PIERCE ALBERT
Inventor： SALITURO FRANCESCO , FARMER LUC , WANG TIANSHENG , WANG JIAN , BETHIEL RANDY , WANNAMAKER MARION , MARTINEZ-BOTELLA GABRIEL , DUFFY JOHN , ARONOV ALEXANDER , LAUFFER DAVID , PIERCE ALBERT
IPC: C07D487/04 , A61K31/495 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D519/00
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract translation: 本发明涉及用作蛋白激酶抑制剂，特别是JAK家族激酶的抑制剂的式（I）化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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4.发明申请
公开(公告)号：WO2008116139A3
公开(公告)日：2008-12-18
申请号：PCT/US2008057797
申请日：2008-03-21
Applicant: VERTEX PHARMA , WANNAMAKER MARION , SALITURO FRANCESCO , PIERCE ALBERT , ARONOV ALEXANDER , MARTINEZ-BOTELLA GABRIEL , WANG JIAN , FARMER LUC , LEDEBOER MARK , WANG TIANSHENG , BETHIEL RANDY , LEDFORD BRIAN , PORTER EMILIE
Inventor： WANNAMAKER MARION , SALITURO FRANCESCO , PIERCE ALBERT , ARONOV ALEXANDER , MARTINEZ-BOTELLA GABRIEL , WANG JIAN , FARMER LUC , LEDEBOER MARK , WANG TIANSHENG , BETHIEL RANDY , LEDFORD BRIAN , PORTER EMILIE
IPC: C07D213/74 , A61K31/506 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/04 , C07D417/04 , C07D417/12 , C07D471/04
CPC classification number: C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：WO2007084557A3
公开(公告)日：2007-09-27
申请号：PCT/US2007001225
申请日：2007-01-17
Applicant: VERTEX PHARMA , FARMER LUC , MARTINEZ-BOTELLA GABRIEL , PIERCE ALBERT , SALITURO FRANCESCO , WANG JIAN , WANNAMKER MARION , WANG TIANSHENG
Inventor： FARMER LUC , MARTINEZ-BOTELLA GABRIEL , PIERCE ALBERT , SALITURO FRANCESCO , WANG JIAN , WANNAMKER MARION , WANG TIANSHENG
IPC: C07D471/04 , A61K31/506 , A61K31/517 , A61K31/53 , A61P25/00 , A61P29/00 , A61P37/00 , C07D519/00
CPC classification number: A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
Abstract: The present invention relates to azaindole compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂，尤其是JAK家族激酶抑制剂的氮杂吲哚化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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Patent Agency Ranking
公开(公告)号：WO2006071644A8
公开(公告)日：2006-08-24
申请号：PCT/US2005046177
申请日：2005-12-20
Applicant: VERTEX PHARMA , ARONOV ALEX , HALE MICHAEL R , MALTAIS FRANCOIS , MARTINEZ-BOTELLA GABRIEL , STRAUB JUDITH , TANG QING
Inventor： ARONOV ALEX , HALE MICHAEL R , MALTAIS FRANCOIS , MARTINEZ-BOTELLA GABRIEL , STRAUB JUDITH , TANG QING
IPC: C07D403/04 , A61K31/506 , A61P35/00
CPC classification number: C07D403/04
Abstract: Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferate disorders such as cancer.
Abstract translation: 本文描述的是可用作ERK2抑制剂的化合物。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括增殖性疾病如癌症）的严重性。
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公开(公告)号：WO2006065820A2
公开(公告)日：2006-06-22
申请号：PCT/US2005045079
申请日：2005-12-13
Applicant: VERTEX PHARMA , MARTINEZ-BOTELLA GABRIEL , ARONOV ALEX , HALE MICHAEL R , MALTAIS FRANCOIS , STRAUB JUDITH , TANG QING
Inventor： MARTINEZ-BOTELLA GABRIEL , ARONOV ALEX , HALE MICHAEL R , MALTAIS FRANCOIS , STRAUB JUDITH , TANG QING
CPC classification number: C07D239/48
Abstract: Described herein are compounds that are useful as protein kinase inhibitors of formula (I); or a pharmaceutically acceptable salt thereof, wherein Ring A, Z 1 , Z 2 , U, Q, R 1 , R 2 , and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
Abstract translation: 本文描述的是可用作式（I）的蛋白激酶抑制剂的化合物; 或其药学上可接受的盐，其中环A，Z 1，Z 2，U，Q，R 1，R 2， 和/或L如本文所定义。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括增殖性疾病如癌症）的严重性。
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公开(公告)号：ES2751761T3
公开(公告)日：2020-04-01
申请号：ES17184079
申请日：2005-05-13
Applicant: VERTEX PHARMA
Inventor： MARTINEZ-BOTELLA GABRIEL , HALE MICHAEL , MALTAIS FRANÇOIS , TANG QING , STRAUB JUDITH
IPC: C07D401/04 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P37/00 , C07F9/58 , C07F9/6558
Abstract: Un compuesto de fórmula I:**Fórmula** o una sal farmacéuticamente aceptable del mismo, en el que: R1 es un grupo alifático C1-6, en el que R1 está opcionalmente sustituido con hasta 2 grupos independientemente seleccionados entre -OR o -haloalquilo C1-3; cada R es independientemente hidrógeno o alifático C1-4; R2 es hidrógeno, alifático C1-3, o cloro; m es 0, 1 o 2; y R3 es hidrógeno, alifático C1-3, flúor o cloro.
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公开(公告)号：ES2401192T8
公开(公告)日：2013-05-10
申请号：ES06815526
申请日：2006-09-28
Applicant: VERTEX PHARMA
Inventor： SALITURO FRANCESCO , FARMER LUC , WANG TIANSHENG , WANG JIAN , BETHIEL RANDY , WANNAMAKER MARION , MARTINEZ-BOTELLA GABRIEL , DUFFY JOHN , ARONOV ALEXANDER , LAUFFER DAVID , PIERCE ALBERT
IPC: C07D487/04 , A61K31/495 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D519/00
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公开(公告)号：AU2007207533B8
公开(公告)日：2012-06-28
申请号：AU2007207533
申请日：2007-01-17
Applicant: VERTEX PHARMA
Inventor： WANNAMAKER MARION , SALITURO FRANCESCO , MARTINEZ-BOTELLA GABRIEL , WANG TIANSHENG , PIERCE ALBERT , FARMER LUC , WANG JIAN
IPC: C07D471/04 , A61K31/506 , A61K31/517 , A61K31/53 , A61P25/00 , A61P29/00 , A61P37/00 , C07D495/10 , C07D519/00
Abstract: The present invention relates to azaindole compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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