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1.发明授权公开(公告)号：US12135969B2
公开(公告)日：2024-11-05
申请号：US17261811
申请日：2019-07-19
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu , Stanislaw Potyrala , Alex Tsipirovich
Abstract: Electromagnetic systems and corresponding methods for assembling the electromagnetic systems are described. The electromagnetic systems can be used in fluid processing systems that include a plurality of fluid containers, each configured to define a fluid chamber that receives a fluid and a plurality of magnetic particles, and a plurality of electromagnets configured to generate a magnetic field within at least one of the plurality of the fluid containers. The fluid processing system can also include a PCB board that supplies the electromagnets with electrical current by establishing an electrical connection between electrical contact terminals included on the PCB board and spring loaded connections included on each electromagnet. A control component controls the electromagnetic field generated by each electromagnet to generate a plurality of magnetic field gradients within the at least one fluid container sufficient to magnetically influence the plurality of magnetic particles within the fluid in each fluid container.
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公开(公告)号：US20240312774A1
公开(公告)日：2024-09-19
申请号：US18268438
申请日：2021-09-24
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Peter Kovarik , Thomas Covey , Gordana Ivosev , Chang Liu
CPC classification number: H01J49/0418 , H01J49/0036
Abstract: Systems and methods are disclosed for timed introduction of samples into a mass spectrometer may include receiving a plurality of sample ion pulses in a mass spectrometer from a sampling interface, where the sample ion pulses are received at a pre-determined time pattern; detecting the received sample ion pulses to generate a signal; isolating an analyte signal by signal conditioning the generated signal based on the pre-determined time pattern; and identifying a presence of an analyte based on the isolated analyte signal. The signal conditioning may include pulse-based averaging based on the pre-determined time pattern or may include converting the generated signal to a frequency-domain signal and calculating a modulus to isolate the analyte signal. The pre-determined time pattern may be periodic where the signal conditioning comprises performing a Fourier Transform on the signal to convert it to a frequency-domain signal.
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公开(公告)号：US11817302B2
公开(公告)日：2023-11-14
申请号：US18046986
申请日：2022-10-17
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu
CPC classification number: H01J49/0495 , G01N1/405 , H01J49/0404 , H01J49/165 , G01N2030/009
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
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4.发明公开公开(公告)号：US20230349858A1
公开(公告)日：2023-11-02
申请号：US17753921
申请日：2020-09-29
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R. Covey , Chang Liu
IPC: G01N27/623 , H01J49/04 , G01N27/624
CPC classification number: G01N27/623 , H01J49/0459 , G01N27/624
Abstract: MS-based methods and systems are provided herein in which a desorption solvent desorbs one or more analyte species from an SPME device within a sampling interface that is fluidly coupled to an ion source for subsequent mass spectrometric analysis. In accordance with various aspects of the applicants teachings, the sampling interface includes an internal sampling conduit that provides increased interaction between the desorption solvent and the sampling substrate, thereby improving mass transfer (e.g., increased extraction or desorption speed).
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5.发明公开公开(公告)号：US20230290627A1
公开(公告)日：2023-09-14
申请号：US18121550
申请日：2023-03-14
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
CPC classification number: H01J49/0454 , H01J49/0404 , H01J49/165 , H01J49/0031 , B01L3/0268 , G01N29/222 , G01N29/02 , H01J49/045 , H01J49/0445 , B01L2400/0439 , B01L2400/0436
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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Patent Agency Ranking
公开(公告)号：US20230207298A1
公开(公告)日：2023-06-29
申请号：US17999637
申请日：2021-05-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Chang Liu , Thomas R. Covey
CPC classification number: H01J49/0454 , H01J49/165
Abstract: An optimal value is calculated for at least one parameter of an ADE device, an OPI, or an ion source device. For each value of a plurality of parameter values for at least one parameter of the ADE device, the OPI, or the ion source device, three steps are performed using a processor. First, the at least one parameter is set to the value. Second, the ADE device, the OPI, the ion source device, and a mass spectrometer are instructed to produce one or more intensity versus time mass peaks for a sample. Third, a feature value is calculated for at least one feature of the one or more intensity versus time mass peaks. A plurality of feature values corresponding to the plurality of parameter values is produced. An optimal value is calculated for the at least one parameter from the plurality of feature values.
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7.发明申请公开(公告)号：US20220139690A1
公开(公告)日：2022-05-05
申请号：US17427428
申请日：2020-02-03
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Chang Liu , Stephen A Tate
Abstract: A device that produces charged droplets whose composition is optimized for the creation of ions by electro spray composed of: a transport device that is operative to transfer sample components from a liquid sample to a processing chamber, a flowing stream of liquid through the processing chamber into which the samples are deposited, a controller mechanism operative to control the amount of sample transferred, a transport tube through which the flowing liquid containing the sample is directed to an electro spray emitter with a high electric field at the exit, a flow of expanding gas surrounding the electro spray emitter creating a pressure drop at the exit, and, a mass spectrometer for measuring the number of ions produced from the charged droplets emanating from the emitter; wherein the dilution of the sample in the processing chamber and transport fluid is from 100 to 10,000-fold.
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公开(公告)号：US20210384023A1
公开(公告)日：2021-12-09
申请号：US17410758
申请日：2021-08-24
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
IPC: H01J49/04 , H01J49/16 , H01J49/00 , B01L3/02 , G01N29/28 , G01N29/24 , G01N24/00 , G01N1/38 , G01N29/22 , G01N29/02 , G01N35/10 , B05B17/06
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US20210265150A1
公开(公告)日：2021-08-26
申请号：US17255861
申请日：2019-06-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R Covey , Chang Liu
IPC: H01J49/04
Abstract: Methods and systems for delivering liquid sample to an ion source and subsequent analysis by mass spectrometry. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which desorption solvent is used in sampling interface to desorb analyte species from an SPME device that is coupled to an ion source to ionize analyte species desorbed into the desorption solvent for MS analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In various aspects of the methods and systems described herein, configuring the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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10.发明授权公开(公告)号：US10001456B2
公开(公告)日：2018-06-19
申请号：US15511712
申请日：2015-08-28
Applicant: DH Technologies Development PTE Ltd.
Inventor： John L Campbell , Yves LeBlanc , Chang Liu
IPC: C07K1/14 , C07K1/00 , B01D59/44 , B01D15/38 , B01D15/36 , C12Q1/68 , G01N33/53 , H01J49/26 , G01N27/62 , H01J49/04 , H01J49/10
CPC classification number: G01N27/624 , G01N33/6803 , H01J49/04 , H01J49/10
Abstract: Methods and systems for separating and/or quantifying peptides using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can provide for the separation of one or more peptides, for example, peptides that may be difficult to separate with conventional techniques, such as mass spectrometry (MS), by complexing the peptides with a metal cation (e.g., Ca2+) prior to DMS. In some aspects, the present teachings can prevent proton stripping from ionized peptides that can occur in DMS to prevent unintended and/or undesirable alterations to the peptide's charge state distribution.
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