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    Enhanced Spray Formation for Liquid Samples
    1.
    发明申请
    Enhanced Spray Formation for Liquid Samples 有权
    液体样品增强喷雾形成

    公开(公告)号：US20160181082A1

    公开(公告)日：2016-06-23

    申请号：US14910032

    申请日：2014-08-05

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Thomas Covey ,  Peter Kovarik

    IPC: H01J49/16 ,  H01J49/04

    CPC classification number: H01J49/165 ,  H01J49/045

    Abstract: Methods and systems for generating ions from a liquid sample for mass spectrometry are provided herein. In various aspects, the methods and systems can enhance the break-up of a jet of the liquid sample upon injection into an ionization chamber. In some aspects, methods and systems perturb the liquid sample prior to discharge to increase the internal energy of the sample so as to enhance the formation of liquid droplets when the liquid sample is injected into the ionization chamber.

    Abstract translation: 本文提供了用于从用于质谱的液体样品产生离子的方法和系统。 在各个方面，所述方法和系统可以在注入电离室时增强液体样品的射流的分解。 在一些方面，方法和系统在放电之前扰乱液体样品以增加样品的内部能量，以便当液体样品注入电离室时增强液滴的形成。

    Method and system for introducing make-up flow in an electrospray ion source system
    2.
    发明授权
    Method and system for introducing make-up flow in an electrospray ion source system 有权
    在电喷雾离子源系统中引入补充流的方法和系统

    公开(公告)号：US09196468B2

    公开(公告)日：2015-11-24

    申请号：US14395705

    申请日：2013-05-17

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： John L. Campbell ,  Thomas Covey ,  Yves LeBlanc ,  Bradley B. Schneider

    IPC: B05B5/025 ,  G01N30/02 ,  H01J49/00 ,  F23D11/22 ,  H01J49/16 ,  G01N27/62 ,  H01J49/04

    CPC classification number: H01J49/165 ,  G01N27/622 ,  H01J49/0081 ,  H01J49/0431

    Abstract: An electrospray ion source method and system is provided for detecting emitter failure comprising a liquid chromatography column suitable for chromatographic separation of a sample. The column can have an inlet for receiving the sample; and an outlet for ejecting the sample. A make-up flow channel is provided for introducing make-up flow of liquid to the sample post-column, wherein the make-up flow normalizes the spray current. An electrospray ionization source is provided having one or more electrospray ionization emitter nozzles for receiving the make-up flow containing sample. A power supply can provide a voltage to the one or more emitter nozzles, and a measurement device can measure and monitor the spray current.

    Abstract translation: 提供了一种用于检测发射器故障的电喷雾离子源方法和系统，其包括适于样品色谱分离的液相色谱柱。 该柱可以具有用于接收样品的入口; 以及用于喷射样品的出口。 提供了补充流动通道，用于将液体的补充流引入样品后柱，其中补充流使归一化喷雾电流。 提供了具有一个或多个电喷雾电离发射器喷嘴的电喷雾离子源，用于接收含有补充流的样品。 电源可以向一个或多个发射器喷嘴提供电压，并且测量装置可以测量和监测喷射电流。

    SYSTEMS AND METHODS FOR MULTI-CHANNEL DIFFERENTIAL MOBILITY SPECTROMETRY
    3.
    发明申请
    SYSTEMS AND METHODS FOR MULTI-CHANNEL DIFFERENTIAL MOBILITY SPECTROMETRY 审中-公开

    公开(公告)号：US20190086363A1

    公开(公告)日：2019-03-21

    申请号：US16085239

    申请日：2017-03-15

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Thomas Covey ,  Yang Kang ,  Chang Liu ,  Bradley Schneider

    IPC: G01N27/62 ,  H01J49/06

    Abstract: In accordance with various aspects of the present teachings, methods and systems for differential mobility spectrometry are provided herein for simultaneously applying a plurality of SV/CV combinations to subsets of a population of ions generated by one or more ion sources. In various aspects, DMS devices in accordance with the present teachings can provide multiple channels (e.g., 2, 3, 4, 5, 6, or more) for operating in parallel and within which different electrical fields can be generated for filtering sample ions within those channels based on the characteristic mobilities of the ions within each channel. In this manner, devices and methods in accordance with the present teachings can, in various aspects, enable improved duty cycle, increased throughput, decreased sample consumption, increased sensitivity for a plurality of ions of interest, and/or increased resolution.

    Enhanced spray formation for liquid samples
    4.
    发明授权
    Enhanced spray formation for liquid samples 有权

    公开(公告)号：US09653276B2

    公开(公告)日：2017-05-16

    申请号：US14910032

    申请日：2014-08-05

    Applicant: DH Technologies Development PTE Ltd.

    Inventor： Thomas Covey ,  Peter Kovarik

    IPC: H01J49/04 ,  H01J49/16

    CPC classification number: H01J49/165 ,  H01J49/045

    Abstract: Methods and systems for generating ions from a liquid sample for mass spectrometry are provided herein. In various aspects, the methods and systems can enhance the break-up of a jet of the liquid sample upon injection into an ionization chamber. In some aspects, methods and systems perturb the liquid sample prior to discharge to increase the internal energy of the sample so as to enhance the formation of liquid droplets when the liquid sample is injected into the ionization chamber.

    SYSTEM AND METHOD FOR THE ACOUSTIC LOADING OF AN ANALYTICAL INSTRUMENT USING A CONTINUOUS FLOW SAMPLING PROBE
    6.
    发明申请
    SYSTEM AND METHOD FOR THE ACOUSTIC LOADING OF AN ANALYTICAL INSTRUMENT USING A CONTINUOUS FLOW SAMPLING PROBE 有权

    公开(公告)号：US20210090867A1

    公开(公告)日：2021-03-25

    申请号：US16985076

    申请日：2020-08-04

    Applicant: Labcyte, Inc. ,  DH Technologies Development Pte. Ltd.

    Inventor： Sammy Datwani ,  Don W. Arnold ,  Lucien P. Ghislain ,  Chang Liu ,  Thomas Covey

    IPC: H01J49/04 ,  H01J49/16 ,  H01J49/00 ,  B01L3/02

    Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.

    METHOD AND SYSTEM FOR TIMED INTRODUCTION OF SAMPLE INTO A MASS SPECTROMETER
    7.
    发明公开
    METHOD AND SYSTEM FOR TIMED INTRODUCTION OF SAMPLE INTO A MASS SPECTROMETER 审中-公开

    公开(公告)号：US20240312774A1

    公开(公告)日：2024-09-19

    申请号：US18268438

    申请日：2021-09-24

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Peter Kovarik ,  Thomas Covey ,  Gordana Ivosev ,  Chang Liu

    IPC: H01J49/04 ,  H01J49/00

    CPC classification number: H01J49/0418 ,  H01J49/0036

    Abstract: Systems and methods are disclosed for timed introduction of samples into a mass spectrometer may include receiving a plurality of sample ion pulses in a mass spectrometer from a sampling interface, where the sample ion pulses are received at a pre-determined time pattern; detecting the received sample ion pulses to generate a signal; isolating an analyte signal by signal conditioning the generated signal based on the pre-determined time pattern; and identifying a presence of an analyte based on the isolated analyte signal. The signal conditioning may include pulse-based averaging based on the pre-determined time pattern or may include converting the generated signal to a frequency-domain signal and calculating a modulus to isolate the analyte signal. The pre-determined time pattern may be periodic where the signal conditioning comprises performing a Fourier Transform on the signal to convert it to a frequency-domain signal.

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