公开(公告)号：US08390805B2

公开(公告)日：2013-03-05

申请号：US12846524

申请日：2010-07-29

Applicant: Huei Pei Kuo ,  Zhiyong Li ,  R. Stanley Williams

Inventor： Huei Pei Kuo ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/0227 ,  G01J3/26 ,  G01J3/36 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy system includes a surface enhanced Raman spectroscopy substrate and a laser source configured to emit light within a spectrum of wavelengths toward a predetermined species on or near the surface enhanced Raman spectroscopy substrate. The system further includes a set of filters positioned to be in optical communication with light scattered after the laser light interacts with the predetermined species. Each of the filters in the set is respectively configured to pass scattered light within a different predetermined narrow band of wavelengths. The system also includes a plurality of photodetectors, where each photodetector is positioned adjacent to a respective one of the filters in the set and is configured to output a signal if the scattered light passes through the respective one of the filters. The set of filters is targeted for detection of characteristic peaks of the predetermined species.

Abstract translation: 表面增强拉曼光谱系统包括表面增强拉曼光谱基板和激光源，该激光源被配置为向表面增强拉曼光谱基板上或附近的预定物质发射波长光谱的光。 该系统还包括一组滤光器，其被定位成在激光与预定物质相互作用之后与散射的光光通信。 集合中的每个滤光器分别被配置成使不同预定的窄波段内的散射光通过。 该系统还包括多个光电检测器，其中每个光电检测器被定位成与集合中的相应一个滤光器相邻，并且被配置为如果散射光通过相应的一个滤光器则输出信号。 该组滤波器用于检测预定种类的特征峰。

公开(公告)号：US08018582B2

公开(公告)日：2011-09-13

申请号：US12442109

申请日：2007-08-30

Applicant: Dae-Hong Jeong ,  Yoon-Sik Lee ,  Myung-Haing Cho ,  Yong-Kweon Kim

Inventor： Dae-Hong Jeong ,  Yoon-Sik Lee ,  Myung-Haing Cho ,  Yong-Kweon Kim

IPC: G01J3/44 ,  G01N21/47 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01J3/02 ,  G01J3/0227 ,  G01J3/0291 ,  G01J3/44 ,  G01N2015/0038 ,  G01N2015/0092 ,  G01N2015/1493

Abstract: Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies.

Abstract translation: 提供了拉曼散射和光散射的检测装置，更具体地，涉及拉曼散射和动态光散射的同时检测装置以及使用该检测装置的检测方法。 拉曼散射和光散射的同时检测装置包括：用于将入射光施加到样品的检测单元，并且以90°或180°几何形状检测拉曼散射并以90°或180°几何形状的光散射检测拉曼散射，以便同时收集拉曼 散射和光散射; 以及连接到检测单元的计算机，以从所检测到的光散射中获得粒子的大小和分布中的至少一个，并且从检测到的拉曼散射获得分子结构的信息。 该装置可以根据材料的尺寸和分布的材料变化和材料的变化同时观察纳米尺寸或更大的材料的尺寸及其分子信息，以及伴随分子环境变化的现象，因此对于研究纳米材料和 蛋白质抗原和抗体。

公开(公告)号：US07944555B2

公开(公告)日：2011-05-17

申请号：US12551404

申请日：2009-08-31

Applicant: Ricardo Claps

Inventor： Ricardo Claps

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/2889 ,  G01J3/32 ,  G01J2003/123 ,  G01N21/65

Abstract: A new architecture for implementing a time-resolved Raman spectrometer is 2-3 orders of magnitude faster than current systems. In one embodiment, the invention employs a rotating optical switch to time multiplex an input signal through multiple band-pass filters and into a single optical detector which is electrically activated only when the filtered input light pulse is about to impact it.Time-multiplexing the input signal through multiple optical filters and time-sequencing the optical detector enables the device to detect and analyze 2-3 orders of magnitude faster than current designs. In one embodiment, the system may be employed for the diagnostics of a pathological condition of skin tissue in patients, such as malignant melanoma or other types of skin cancers and abnormal conditions.

Abstract translation: 实现时间分辨拉曼光谱仪的新架构比现有系统快2-3个数量级。 在一个实施例中，本发明采用旋转光开关，通过多个带通滤波器对输入信号进行时间复用，并将其转换成仅在滤波后的输入光脉冲即将影响时才被电激活的单个光检测器。 通过多个光学滤波器对输入信号进行时分复用，并对光学检测器进行时间排序，使器件能够比目前的设计更快地检测和分析2-3个数量级。 在一个实施方案中，该系统可用于诊断患者皮肤组织的病理状况，例如恶性黑素瘤或其他类型的皮肤癌症和异常状况。

公开(公告)号：US07701571B2

公开(公告)日：2010-04-20

申请号：US11894887

申请日：2007-08-22

Applicant: Masud Azimi ,  Kevin J. Knopp ,  Steve McLaughlin

Inventor： Masud Azimi ,  Kevin J. Knopp ,  Steve McLaughlin

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/024 ,  G01J3/0291 ,  G01N21/65 ,  G01N2021/656 ,  G01N2201/08

Abstract: A Raman spectrometry assembly includes a Raman spectrometer having a laser light source and a Raman signal analyzer, an interface module comprising a housing which is connectable to and disconnectable from the spectrometer, and a fiber optic assembly which is connectable to and disconnectable from the interface module, the fiber optic assembly including optical fibers and a probe head at a distal end thereof for disposition adjacent a specimen to be tested, the optical fibers extending from the probe head and adapted to extend to the interface module.

Abstract translation: 拉曼光谱仪组件包括具有激光光源和拉曼信号分析器的拉曼光谱仪，包括可与光谱仪连接并可与光谱仪分离的外壳的接口模块，以及可与接口模块连接并与其分离的光纤组件 ，所述光纤组件包括光纤和在其远端处的探针头，用于邻近待测试的样品布置，所述光纤从探头延伸并适于延伸到接口模块。

公开(公告)号：US20100020312A1

公开(公告)日：2010-01-28

申请号：US12442109

申请日：2007-08-30

Applicant: Dae-Hong Jeong ,  Yoon-Sik Lee ,  Myung-Haing Cho ,  Yong-Kweon Kim

Inventor： Dae-Hong Jeong ,  Yoon-Sik Lee ,  Myung-Haing Cho ,  Yong-Kweon Kim

IPC: G01N21/65 ,  G01N21/47

CPC classification number: G01J3/02 ,  G01J3/0227 ,  G01J3/0291 ,  G01J3/44 ,  G01N2015/0038 ,  G01N2015/0092 ,  G01N2015/1493

Abstract: Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies.

Abstract translation: 提供了拉曼散射和光散射的检测装置，更具体地，涉及拉曼散射和动态光散射的同时检测装置以及使用该检测装置的检测方法。 拉曼散射和光散射的同时检测装置包括：用于将入射光施加到样品的检测单元，并且以90°或180°几何形状检测拉曼散射并以90°或180°几何形状的光散射检测拉曼散射，以便同时收集拉曼 散射和光散射; 以及连接到检测单元的计算机，以从所检测到的光散射中获得粒子的大小和分布中的至少一个，并且从检测到的拉曼散射获得分子结构的信息。 该装置可以根据材料的尺寸和分布的材料变化和材料的变化同时观察纳米尺寸或更大的材料的尺寸及其分子信息，以及伴随分子环境变化的现象，因此对于研究纳米材料和 蛋白质抗原和抗体。

公开(公告)号：US20090065710A1

公开(公告)日：2009-03-12

申请号：US12199984

申请日：2008-08-28

Applicant: Lukas Hunziker ,  Georg Herink ,  Arnaud Lepert

Inventor： Lukas Hunziker ,  Georg Herink ,  Arnaud Lepert

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/646 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0634

Abstract: A method for detecting trace evidence materials on a surface comprises irradiating the surface with radiation from two or more lasers emitting radiation at different wavelengths selected to stimulate luminescence in the trace materials. The evidence is detected by observing the surface through an optical filter arranged to transmit the luminescence, while blocking transmission of the laser radiation wavelengths reflected or scattered from the surface.

Abstract translation: 用于检测表面上的痕量证据材料的方法包括用来自两个或更多个激光器的辐射照射表面，所述激光器发射不同波长的辐射，以激发微量材料中的发光。 通过用布置成透射发光的滤光片观察表面，同时阻挡从表面反射或散射的激光辐射波长的透射来检测证据。

公开(公告)号：US20090033930A1

公开(公告)日：2009-02-05

申请号：US12248344

申请日：2008-10-09

Applicant: John Maier ,  Jeffrey Cohen

Inventor： John Maier ,  Jeffrey Cohen

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0227 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/129

Abstract: A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.

Abstract translation: 鉴定微生物生物膜的光谱方法和系统。 用基本上单色的辐射照射含有样品微生物的样品。 基于从照射样品散射的辐射获得拉曼数据集。 根据拉曼数据集搜索数据库，以便从数据库中识别已知的拉曼数据集。 数据库包含多个已知的拉曼数据集，其中每个已知的拉曼数据集与相应的已知微生物的已知无形形式相关联。 基于通过搜索识别的已知拉曼数据集来鉴定样品微生物的固定形式。

公开(公告)号：US07420664B2

公开(公告)日：2008-09-02

申请号：US11484939

申请日：2006-07-12

Applicant: Patrick J. Treado ,  Charles W. Gardner, Jr.

Inventor： Patrick J. Treado ,  Charles W. Gardner, Jr.

IPC: G01N21/00

CPC classification number: G01N21/474 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/0291 ,  G01J3/44

Abstract: An apparatus and method for the remote analysis and identification of unknown compounds. A robotic arm positions a sensor on a surface. The sensor unit has a monitoring mechanism to monitor separation between the sensor unit and the surface when placed in contact with the surface to maintain the separation substantially constant. An illumination source illuminates the region of interest to produce scattered photons from an unknown compound. The scattered photons are collected by an optical system and delivered to a spectroscopic detector for analysis and identification. An algorithm is applied to the data generated by the spectroscopic detector to identify the unknown compound.

Abstract translation: 用于远程分析和鉴定未知化合物的装置和方法。 机器手臂将传感器定位在表面上。 传感器单元具有监测机构，用于在放置与表面接触时监测传感器单元与表面之间的分离，以保持分离基本恒定。 照明源照亮感兴趣的区域以产生来自未知化合物的散射光子。 散射的光子被光学系统收集并传送到光谱检测器进行分析和识别。 将一种算法应用于由光谱检测器产生的数据，以识别未知化合物。

公开(公告)号：US20080165344A1

公开(公告)日：2008-07-10

申请号：US11484939

申请日：2006-07-12

Applicant: Patrick J. Treado ,  Charles W. Gardner

Inventor： Patrick J. Treado ,  Charles W. Gardner

IPC: G01N21/00

CPC classification number: G01N21/474 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/0291 ,  G01J3/44

Abstract: An apparatus and method for the remote analysis and identification of unknown compounds. A robotic arm positions a sensor on a surface. The sensor unit has a monitoring mechanism to monitor separation between the sensor unit and the surface when placed in contact with the surface to maintain the separation substantially constant. An illumination source illuminates the region of interest to produce scattered photons from an unknown compound. The scattered photons are collected by an optical system and delivered to a spectroscopic detector for analysis and identification. An algorithm is applied to the data generated by the spectroscopic detector to identify the unknown compound.

Abstract translation: 用于远程分析和鉴定未知化合物的装置和方法。 机器手臂将传感器定位在表面上。 传感器单元具有监测机构，用于在放置与表面接触时监测传感器单元与表面之间的分离，以保持分离基本恒定。 照明源照亮感兴趣的区域以产生来自未知化合物的散射光子。 散射的光子被光学系统收集并传送到光谱检测器进行分析和识别。 将一种算法应用于由光谱检测器产生的数据，以识别未知化合物。

公开(公告)号：US07397562B2

公开(公告)日：2008-07-08

申请号：US11475717

申请日：2006-06-26

Applicant: Wayne D Jung ,  Russell W Jung ,  Alan R. Loudermilk

Inventor： Wayne D Jung ,  Russell W Jung ,  Alan R. Loudermilk

IPC: G01J3/51

CPC classification number: G01J3/02 ,  G01J1/0411 ,  G01J1/0437 ,  G01J1/0474 ,  G01J1/06 ,  G01J1/44 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/0229 ,  G01J3/0251 ,  G01J3/0259 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0275 ,  G01J3/0278 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/2803 ,  G01J3/46 ,  G01J3/463 ,  G01J3/508 ,  G01J3/51 ,  G01J3/513

Abstract: A method for determining spectral characteristics of an object is disclosed. A probe is positioned in proximity relative to the object and provides light to a surface of the object and receives light from the object. One or more critical heights are defined below which no specularly refelcted light is received and propagated. Prior to positioning the probe in proximity relative to the object, a plurality of position-sensitive calibration/normalization reference and a plurality of calibration/normalization measurements are taken with the probe at a plurality of predetermined positions with respect to the calibration/normalization reference. The intensity of light received is determined in a plurality of spectral bands with one or more measurements. The spectral characteristics of the object are determined based on the one or more measurements and based on data taken from one or more of the calibration/normalization measurements.

Abstract translation: 公开了一种用于确定物体的光谱特性的方法。 探针相对于物体定位在邻近处，并且向对象的表面提供光并接收来自物体的光。 下面定义了一个或多个关键的高度，其中没有镜面反射光被接收和传播。 在将探针定位在相对于物体附近之前，多个位置敏感的校准/归一化参考和多个校准/归一化测量在探针相对于校准/归一化参考的多个预定位置处被采集。 在具有一个或多个测量的多个光谱带中确定所接收的光的强度。 基于一个或多个测量并且基于从一个或多个校准/归一化测量获取的数据来确定对象的光谱特性。