公开(公告)号：US20020044279A1

公开(公告)日：2002-04-18

申请号：US09973996

申请日：2001-10-09

Inventor： Jed Khoury

IPC: G01J003/00 ,  G01N021/64

CPC classification number: G01N21/6456 ,  A61B5/0059 ,  A61B5/7257 ,  G01J3/28 ,  G01J3/457 ,  G01N2021/6423

Abstract: An angularly multiplexed store contains filters derived from prior examination of input image reference samples, a spectrum analyzer produces spectral data representing the frequency spectrum of the input image under examination, a computer produces an encoded map of the spectral data representing the input image frequency spectrum. The encoded map is transformed, inputted into the store while close match spectral correlation light beams emerge from the multiplexed store, each having an emerging angle associated with that filter within the multiplexed store producing a close match with the first transform. An array of light beam detectors and a display present images having colors that indicate the nature of the input image such as a type of cancer. An associated memory-retro-reflector arrangement displays characters naming the materials making up the input image such as types of abnormal tissue. The disclosed apparatus can have significant application in medicine, food industry, spectroscopy, material science and other various areas.

Abstract translation: 角度多路复用存储器包含从先前检查输入图像参考样本得到的滤波器，频谱分析仪产生表示被检测输入图像的频谱的频谱数据，计算机产生表示输入图像频谱的频谱数据的编码图。 将经编码的图像变换，输入到存储器中，同时从多路复用存储器中出现紧密匹配的频谱相关光束，每个具有与多路复用存储器内的该滤波器相关联的出现角度，产生与第一变换的紧密匹配。 光束检测器和显示器的阵列呈现具有指示诸如癌症类型的输入图像的性质的颜色的图像。 相关联的存储器 - 反射器布置显示命名构成输入图像的材料的字符，例如异常组织的类型。 所公开的装置可以在医药，食品工业，光谱学，材料科学等各个领域都有重要的应用。

公开(公告)号：US20020008211A1

公开(公告)日：2002-01-24

申请号：US09779461

申请日：2001-02-09

Inventor： Peet Kask

IPC: G01N021/64

CPC classification number: G01N21/64 ,  G01J3/4406 ,  G01J3/457 ,  G01J2003/2866 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/6421 ,  G01N2021/6463

Abstract: The present invention relates to a method for characterizing samples having fluorescent particles, comprising the steps of: (a) monitoring intensity fluctuations of fluorescence emitted by the particles in at least one measurement volume by detecting sequences of photon counts by at least one photon detector, (b) determining from the sequences of photon counts intermediate statistical data comprising at least two probability functions, {circumflex over (P)}1(n1),{circumflex over (P)}2(n2), . . . , of the number of photon counts, n1,n2, . . . , detected in different sets of counting time intervals, (c) determining from said intermediate statistical data a distribution of particles as a function of at least two arguments, wherein one argument is a specific brightness of the particles, or a measure thereof, and another argument is a diffusion coefficient of the particles, or a measure thereof.

Abstract translation: 本发明涉及一种用于表征具有荧光颗粒的样品的方法，包括以下步骤：（a）通过至少一个光子检测器检测光子计数序列来监测由至少一个测量体积中的颗粒发射的荧光的强度波动， （b）根据光子计数的序列确定包括至少两个概率函数的中间统计数据{（f）（1）（1），{（f）（2））2（n2）。 。 。 ，光子计数的数量，n1，n2，。 。 。 （c）从所述中间统计数据确定作为至少两个参数的函数的粒子的分布，其中一个参数是粒子的特定亮度或其度量，以及另一个参数 论证是粒子的扩散系数，或其度量。

公开(公告)号：US06029115A

公开(公告)日：2000-02-22

申请号：US940575

申请日：1997-09-30

Applicant: David H. Tracy ,  Alan M. Ganz ,  Yongdong Wang ,  David A. Huppler ,  Juan C. Ivaldi ,  Christopher B. Hanna

Inventor： David H. Tracy ,  Alan M. Ganz ,  Yongdong Wang ,  David A. Huppler ,  Juan C. Ivaldi ,  Christopher B. Hanna

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/457 ,  G01N21/27 ,  G01N21/73 ,  G01R35/00

CPC classification number: G01J3/28 ,  G01J3/2803 ,  G01J3/457 ,  G01J2003/2866

Abstract: A spectrometric instrument includes a detector with detecting subarrays on small portions of the surface. Spectral data are acquired for selected subarrays at a first time for a drift standard, and compared to a zero position to obtain first offset data. Data are acquired similarly at a second time to obtain second offset data. The offset data are utilized to obtain a spectral shift for any subarray position at any selected time. The shift is applied to a matrix model used for converting test data to compositional information. Archive data for the model is obtained in the foregoing manner, using slit scanning in the instrument to achieve sub-increments smaller than the detector pixel size, with a procedure to assure that there is an integral number of scanning steps across one pixel. The drift standard may be chemical analytes, or an optical interference element producing fringes related to spectral positions in each subarray. A procedure is used to identify the fringe peaks to spectral position, with temperature correction.

Abstract translation: 光谱测量仪器包括一个检测器，在表面的小部分具有检测子阵列。 针对漂移标准在第一时间针对所选择的子阵列采集光谱数据，并与零位置进行比较以获得第一偏移数据。 在第二时间类似地获取数据以获得第二偏移数据。 偏移数据用于在任何选定的时间获得任何子阵列位置的光谱偏移。 该转移被应用于用于将测试数据转换成组合信息的矩阵模型。 以上述方式获得用于模型的存档数据，使用仪器中的狭缝扫描来实现小于检测器像素尺寸的次增量，以确保跨越一个像素存在整数个扫描步骤的过程。 漂移标准可以是化学分析物，或者产生与每个子阵列中的光谱位置相关的条纹的光学干涉元件。 使用一个程序来确定边缘峰到光谱位置，并进行温度校正。

公开(公告)号：US5949532A

公开(公告)日：1999-09-07

申请号：US900714

申请日：1997-07-28

Applicant: Wolfgang Schrof ,  Jurgen Klingler ,  Dieter Horn

Inventor： Wolfgang Schrof ,  Jurgen Klingler ,  Dieter Horn

IPC: G01N21/65 ,  G01J3/28 ,  G01J3/44 ,  G01J3/457 ,  G01N21/64

CPC classification number: G01J3/457 ,  G01J3/44 ,  G01J2003/2866

Abstract: A method and an apparatus for determining diffusion parameters, concentration, size or flow behavior of particles in a sample, exciting light of a light source being directed into the sample, Raman scattered light being collected from an observed volume of the sample and being passed on to a spectrograph where it is resolved into spectral lines, the intensity of at least one spectral line being measured at least 10 times per second by means of one photodetector each, and the measured intensity values for the respective spectral line being used, via a fluctuation analysis, preferably an autocorrelation or a frequency analysis, to calculate diffusion parameters, concentration, size or flow behavior of the particle to which the spectral line in question can be assigned. With this method, it is also possible for signals of different spectral lines or bands, or signals of Raman scattered light, quasi-elastically scattered light and fluorescence light to be correlated with one another.

Abstract translation: 用于确定样品中颗粒的扩散参数，浓度，尺寸或流动行为的方法和装置，激发被引入样品的光源的激发光，从观察体积的样品中收集的拉曼散射光，并被传递 对于其被分解成谱线的光谱仪，通过一个光电检测器每秒至少测量10次光谱线的强度，以及通过波动测量各光谱线的测量强度值 分析，优选自相关或频率分析，以计算可以分配所讨论的谱线的粒子的扩散参数，浓度，尺寸或流动行为。 通过该方法，也可以使不同谱线或频带的信号，或拉曼散射光，准弹性散射光和荧光的信号彼此相关。

公开(公告)号：US5867264A

公开(公告)日：1999-02-02

申请号：US950928

申请日：1997-10-15

Applicant: Michele Hinnrichs

Inventor： Michele Hinnrichs

IPC: G01J3/04 ,  G01J3/28 ,  G01J3/457 ,  G01J3/02

CPC classification number: G01J3/2846 ,  G01J3/04 ,  G01J3/457

Abstract: An apparatus for spectral detection of remote objects. The apparatus consists of an input optic which focuses the field of view onto an image receiving surface consisting of an addressable spatial mask. The mask sequentially projects portions of the scene onto a diffractive optical element which focuses onto a photodetector array. The first image receiving surface of mask is partitioned into independently addressable and controllable subsurfaces, or gates, adapted to receive an electronic control signal from a programmable control signal generator. Each gate in the receiving mask directs a portion of the image incident thereon to a diffractive lens in response to a control signal communicated thereto. This gated image is dispersed by the diffractive lens and focused upon the photosensitive surface of a photodetector array. The photodetector array is partitioned into pixels having a number in ratio to the gates in the addressable mask. The signal output of a pixel within the optical path of the dispersed gated light is sampled and stored in a signal processor. A control signal generator sequentially or randomly addresses each gate in the mask causing the gate to direct that portion of the image thereon to the diffractive lens. The output signal from each pixel on the photodetector array corresponding to the addressed gate in the mask is sampled and stored until the entire image is recorded. This process is repeated as the diffractive optic is scanned through the spectral range of interest. The mask provides enhanced spectral and spatial resolution of the scene.

Abstract translation: 一种远程物体光谱检测装置。 该装置由将视场聚焦到由可寻址空间掩模组成的图像接收表面上的输入光学元件组成。 掩模顺序地将场景的部分投影到聚焦到光电检测器阵列上的衍射光学元件上。 掩模的第一图像接收表面被划分成独立可寻址和可控的子表面或门，适于从可编程控制信号发生器接收电子控制信号。 接收掩模中的每个门响应于与其通信的控制信号，将入射到其上的图像的一部分引导到衍射透镜。 该选通图像由衍射透镜分散并聚焦在光电检测器阵列的感光表面上。 光电检测器阵列被划分为与可寻址掩模中的栅极的数量成比例的像素。 分散门控光的光路内的像素的信号输出被采样并存储在信号处理器中。 控制信号发生器顺序地或随机地寻址掩模中的每个栅极，使得栅极将图像的该部分引导到衍射透镜。 对应于掩模中寻址的栅极的光电检测器阵列上每个像素的输出信号被采样并存储直到记录整个图像。 当衍射光学器件通过感兴趣的光谱范围被扫描时，重复该过程。 该面具提供了增强的场景的光谱和空间分辨率。

公开(公告)号：US5815261A

公开(公告)日：1998-09-29

申请号：US838298

申请日：1997-04-16

Applicant: Neil H. Brooks ,  Sergey N. Tugarinov ,  Nicolae N. Naumenko ,  Torkil H. Jensen

Inventor： Neil H. Brooks ,  Sergey N. Tugarinov ,  Nicolae N. Naumenko ,  Torkil H. Jensen

IPC: G01J3/20 ,  G01J3/28 ,  G01J3/457 ,  G01J3/04

CPC classification number: G01J3/20 ,  G01J3/457 ,  G01J2003/2866 ,  G01J3/0229 ,  G01J3/0235

Abstract: A spectrometer that determines a spectral correlation between an optical signal and a reference spectra over a broad spectral range while maintaining a relatively high resolution. The spectrometer uses a mask that has high resolution slits at wavelengths corresponding to the reference spectra. Relative oscillatory movement is induced between the mask and the imaged spectra of the optical signal is induced and the light passing through the slits is collected by an optical sensor. A lock-in amplifier monitors a signal from the optical sensor as well as a signal representative of the oscillatory movement and determines a correlation between them.

Abstract translation: 一种光谱仪，其在保持相对高的分辨率的同时确定光信号与宽光谱范围上的参考光谱之间的光谱相关性。 光谱仪使用在对应于参考光谱的波长处具有高分辨率狭缝的掩模。 在掩模之间引起相对振荡运动，并且感光的光信号的成像光谱被感应，并且通过狭缝的光被光学传感器收集。 锁定放大器监视来自光学传感器的信号以及表示振荡运动的信号，并确定它们之间的相关性。

公开(公告)号：USH780H

公开(公告)日：1990-05-01

申请号：US227570

申请日：1988-08-03

Applicant: Richard L. Hartman

Inventor： Richard L. Hartman

IPC: G01J3/457

CPC classification number: G01J3/457

Abstract: A method of detecting chemical agents present in a sample by utilizing a ctrometer to produce an output spectrum which is transmitted to an optical correlator which processes the output spectra of the spectrometer and identifies particular chemical species present in the sample by utilizing a detector and indicator arrangement.

公开(公告)号：US3836254A

公开(公告)日：1974-09-17

申请号：US88538769

申请日：1969-12-15

Applicant: BARRINGER RESEARCH LTD

Inventor： BARRINGER A

IPC: G01J3/26 ,  G01J3/28 ,  G01J3/30 ,  G01J3/45 ,  G01J3/457 ,  G01J3/00 ,  G01B9/02 ,  G01J3/42

CPC classification number: G01J3/457 ,  G01J2003/2866

Abstract: An optical correlator having an optical wedge or other device for producing a spatially dispersed pattern of light in a plane, the light being characterized by zones of relatively high intensity and low intensity corresponding to spectra present in the incident light or the Fourier transform thereof. The dispersed light is alternately or simultaneously passed through a first mask having a pattern of opaque and transparent regions or lines positioned to correlate with the zones of relatively high intensity light and a second mask having a plurality of opaque and transparent regions or lines positioned to correlate with the relatively low intensity zones of light. A photodetector examines the light passing through the masks and produces and output signal which can be analyzed to determine the character of the incident radiation.

Abstract translation: 一种光学相关器，具有用于在平面中产生空间分散的光图案的光学楔块或其它装置，所述光的特征在于对应于入射光中存在的光谱或其傅里叶变换的相对高强度和低强度的区域。 分散的光交替地或同时地通过具有不透明和透明区域的图案的第一掩模，其被定位成与相对高强度的光的区域相关联，并且第二掩模具有多个不透明和透明的区域或线， 具有相对较低强度的光区。 光电检测器检查通过掩模的光，并产生和输出可分析的信号，以确定入射辐射的特性。

公开(公告)号：US3744918A

公开(公告)日：1973-07-10

申请号：US3744918D

申请日：1971-04-23

Applicant: AGA AB

Inventor： JACOBSSON J

IPC: G01J3/28 ,  G01J3/457 ,  G01J3/02 ,  G01J3/50

CPC classification number: G01J3/457 ,  G01J2003/2866

Abstract: Arrangement for correlation spectroscopy by means of the absorption or emission spectrum of a gas. Light from the gas is arranged to be fed to an analyzer, comprising a light transmitting disc arranged in front of a detector. One side of the disc is supplied with an interference filter which within at least one segment of the filter has transmission characteristics as a function of the wavelength within a determined range of wavelengths. The range of wavelengths corresponds to the absorption or emission spectrum of a searched ingredient in the gas. The other parts of said filter have different transmission characteristics. These parts have different transmission characteristics relative to one another and are arranged to be alternatively inserted into the beam path in front of the detector.

Abstract translation: 通过气体的吸收或发射光谱进行相关光谱的排列。 来自气体的光被布置成被馈送到分析器，包括布置在检测器前面的透光盘。 光盘的一侧被提供有干涉滤光片，其在滤光器的至少一个部分内具有作为在确定的波长范围内的波长的函数的透射特性。 波长范围对应于气体中所搜索的成分的吸收或发射光谱。 所述滤波器的其它部分具有不同的传输特性。 这些部件相对于彼此具有不同的传输特性，并且被布置成交替地插入到检测器前面的光束路径中。

公开(公告)号：US3578980A

公开(公告)日：1971-05-18

申请号：US3578980D

申请日：1969-06-18

Applicant: COMSTOCK & WESCOTT

Inventor： DECKER JOHN A JR ,  HARWIT MARTIN O

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/457 ,  G06K9/00

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/457 ,  G01J2003/2866

Abstract: A light spectrum is projected on a photocell through a movable mask having plural combinations of arrays of light windows and opaque areas which transmit to or mask different portions of the spectral line from the photocell. The combinations of windows and opaque areas in the several arrays are different and distributed according to a set of linearly independent equations forming a matrix. As the mask is advanced stepwise the photocell successively senses all the light transmitted from the spectrum through successively interposed arrays and generates a corresponding group of values with an inverse of the mask matrix so as to derive a series of values representing the distribution of energy along the spectrum. The mask thus analyzes and encodes the spectral energy distribution.