公开(公告)号：US08269191B2

公开(公告)日：2012-09-18

申请号：US12940228

申请日：2010-11-05

Applicant: David Lawrence Rosen ,  Ronald Everett Meyers

Inventor： David Lawrence Rosen ,  Ronald Everett Meyers

IPC: G01J1/58

CPC classification number: G01J1/58 ,  G01J1/0429 ,  G01J1/0488 ,  G01J3/0224 ,  G01J3/44 ,  G01J3/443 ,  G01J4/00

Abstract: An apparatus for determining the depolarization efficiency of a environment includes a transmitter, a receiver, and signal processing circuitry. A reference object is located within the environment at a reference distance. The transmitter includes a radiation source providing incident radiation that has an initial polarization as it enters the environment. The receiver receives returned radiation from the reference, which may be diffuse reflection or photoluminescence. The signal processing circuitry calculates the depolarization efficiency of the environment from the initial polarization, luminescence or final polarization, and the reference distance. A method of determining depolarization efficiency includes directing incident radiation having initial polarization through an environment onto a reference, detecting returned radiation from the reference, and calculating the depolarization efficiency using the initial polarization and the luminescence or final polarization.

Abstract translation: 用于确定环境的去极化效率的装置包括发射器，接收器和信号处理电路。 参考对象位于环境中的参考距离处。 发射机包括提供入射辐射的辐射源，入射辐射在其进入环境时具有初始极化。 接收器接收来自参考物的返回辐射，其可以是漫反射或光致发光。 信号处理电路从初始极化，发光或最终极化以及参考距离计算环境的去极化效率。 确定去极化效率的方法包括将具有通过环境的初始极化的入射辐射引导到参考，检测来自参考物的返回辐射，以及使用初始极化和发光或最终极化来计算去极化效率。

公开(公告)号：US08264681B2

公开(公告)日：2012-09-11

申请号：US12639393

申请日：2009-12-16

Applicant: Anupam Kumar Misra ,  Shiv Kumar Sharma ,  Paul Grandmont Lucey

Inventor： Anupam Kumar Misra ,  Shiv Kumar Sharma ,  Paul Grandmont Lucey

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0227 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/443

Abstract: An spectrometer including Raman and LIBS spectroscopy capabilities is disclosed. The spectrometer includes a laser source configurable to produce a lased light directable towards a target substance, the laser source having a single wavelength and having sufficient power to cause a portion of the target to emit Raman scattering and sufficient to ablate a portion of the target substance to produce a plasma plume. A separate remote light collector is optically configurable to collect light emitted from the portion of the target emitting Raman scattering and from the portion of the target producing the plasma plume. A filter is optically coupled to the remote light collector to remove reflected light and Rayleigh-scattered light, and a spectroscope is optically coupled to the filter and configured to separate the collected and filtered light into a frequency spectrum comprising a Raman spectrum and a laser-induced breakdown spectrum. Finally, an electronic light sensor is used to record the frequency spectrum.

Abstract translation: 公开了包括拉曼和LIBS光谱能力的光谱仪。 光谱仪包括可配置为产生可朝向目标物质定向的激光的激光源，激光源具有单一波长并具有足够的功率以使靶的一部分发射拉曼散射并足以消除目标物质的一部分 以产生等离子体羽流。 单独的远程收光器是可光学配置的，以收集从发射拉曼散射的目标的部分和从产生等离子体羽流的目标的部分发射的光。 滤光器光耦合到远程光收集器以去除反射光和瑞利散射光，并且光谱仪光学耦合到滤光器并且被配置为将收集的和经过滤光的光分离成包括拉曼光谱和激光 - 诱发击穿光谱。 最后，使用电子光传感器来记录频谱。

公开(公告)号：US20120212736A1

公开(公告)日：2012-08-23

申请号：US13401199

申请日：2012-02-21

Applicant: PI LING HUANG ,  KUANG-YU HSU ,  CHENG-KAI WANG ,  EDMUND SUN ,  SHENG-LUNG HUANG

Inventor： PI LING HUANG ,  KUANG-YU HSU ,  CHENG-KAI WANG ,  EDMUND SUN ,  SHENG-LUNG HUANG

IPC: G01J3/44 ,  G02B6/00

CPC classification number: G01J3/0218 ,  G01J3/0245 ,  G01J3/10 ,  G01J3/44 ,  H01S3/06716 ,  H01S3/09415 ,  H01S3/1623 ,  H01S3/1625 ,  H01S3/1636 ,  H01S5/32341

Abstract: The invention relates to a crystal fiber, a Raman spectrometer using the same and a inspection method thereof. The crystal fiber comprises a sapphire crystal is doped with two transition metals having different concentrations. An excitation light beam at a specific wavelength can propagate along the crystal fiber to generate a narrow-band light beam and a wide-band light beam to project on a specimen. Raman scattered light is emitted from the specimen. The wavelength of the Raman scattered light falls within the wavelength range of the wide-band light beam so that the wide-band light beam is enhanced at some characteristic wavelengths to facilitate Raman spectroscopy.

Abstract translation: 本发明涉及一种晶体纤维，使用其的拉曼光谱仪及其检查方法。 晶体纤维包括蓝宝石晶体，其掺杂有两种不同浓度的过渡金属。 特定波长的激发光束可以沿着晶体光纤传播，以产生窄带光束和宽带光束投影在样本上。 拉曼散射光从样品中排出。 拉曼散射光的波长落在宽带光束的波长范围内，使得宽带光束在某些特征波长处被增强以促进拉曼光谱。

公开(公告)号：US20120212735A1

公开(公告)日：2012-08-23

申请号：US13394979

申请日：2010-09-09

Applicant: Göran Palmskog ,  Olof Beck ,  Per Ola Andersson

Inventor： Göran Palmskog ,  Olof Beck ,  Per Ola Andersson

IPC: G01J3/44

CPC classification number: G01N21/658 ,  A61B5/082 ,  A61B5/412 ,  G01J3/44 ,  G01N33/497

Abstract: A sensor for detecting a drug substance (15) from exhaled breath of a subject in-situ. Its collecting surface has a Surface Enhanced Raman Spectroscopy (SERS)-active layer (14) of a SERS-active material. The collecting surface is arranged as an outer surface of a waveguide (12) for contact with exhaled breath, such that at least traces of said drug substance (15) in said exhaled breath can contact said SERS-active layer for read-out of a Raman shift spectrum.

公开(公告)号：US08248600B2

公开(公告)日：2012-08-21

申请号：US12516170

申请日：2007-11-21

Applicant: Pavel Matousek ,  Eva Charlotte Eliasson

Inventor： Pavel Matousek ,  Eva Charlotte Eliasson

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/44

Abstract: Methods and apparatus for screening the unknown contents of containers using Raman spectroscopy are disclosed, especially for security screening applications such as in airports. A probe light beam is directed through the wall of a container to a sample region within the container contents. Light scattered out of the beam within the sample region is collected along a path which passes through a separate part of the container wall, for Raman spectral analysis.

Abstract translation: 公开了使用拉曼光谱法筛选容器的未知内容物的方法和装置，特别是对于诸如在机场中的安全筛选应用。 探针光束通过容器的壁被引导到容器内容器内的样品区域。 沿着通过容器壁的单独部分的路径收集在样品区域内从光束散射的光，以进行拉曼光谱分析。

公开(公告)号：US08243270B2

公开(公告)日：2012-08-14

申请号：US12697156

申请日：2010-01-29

Applicant: Huei Pei Kuo ,  Michael J. Stuke ,  Min Hu ,  Fung Suong Ou ,  Shih-Yuan (SY) Wang ,  Alexandre M. Bratkovski ,  Wei Wu ,  Zhiyong Li

Inventor： Huei Pei Kuo ,  Michael J. Stuke ,  Min Hu ,  Fung Suong Ou ,  Shih-Yuan (SY) Wang ,  Alexandre M. Bratkovski ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01J3/44

Abstract: A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.

Abstract translation: 振动尖端表面增强拉曼光谱（SERS）装置，系统和方法采用配置为振动的纳米针。 该装置包括在与连接到基底的端相对的自由端处具有基本尖锐的尖端的纳米针。 尖端构造成吸附分析物。 该装置还包括一个被配置为提供交流（AC）电场的振动源，其引起自由端和纳米针的尖端的振动。 在AC电场的影响下，纳米针的振动有助于检测吸附在纳米针尖上的分析物的拉曼散射信号。 该系统还包括配置为与纳米针的振动协同地选通的同步检测器。 该方法包括引起振动，照亮振动尖端以产生拉曼信号，并使用检测器检测拉曼信号。

公开(公告)号：US20120194814A1

公开(公告)日：2012-08-02

申请号：US13359758

申请日：2012-01-27

Applicant: Sean Xiaolu Wang

Inventor： Sean Xiaolu Wang

IPC: G01J3/44 ,  G01J3/443 ,  G01J3/28

CPC classification number: G01J3/44 ,  G01J3/021

Abstract: An improved apparatus and method for performing Raman spectroscopy in a scattering medium, where the scattering induced phase modulation is compensated by using a spatial light modulator to shape the wavefront of the laser beam. This allows the laser beam to be focused to a spot inside the inhomogeneous material with low distortion, thus stimulating Raman signal from the focus point for spectral analysis.

Abstract translation: 一种用于在散射介质中执行拉曼光谱的改进的装置和方法，其中通过使用空间光调制器来补偿激光束的波前的散射感应相位调制。 这允许激光束被聚焦到具有低失真的不均匀材料内的点，从而从聚焦点刺激拉曼信号用于光谱分析。

公开(公告)号：US08213004B2

公开(公告)日：2012-07-03

申请号：US12409056

申请日：2009-03-23

Applicant: Masayuki Naya ,  Yuichi Tomaru ,  Naoki Murakami

Inventor： Masayuki Naya ,  Yuichi Tomaru ,  Naoki Murakami

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/0205 ,  G01J3/0264 ,  G01J3/027 ,  G01N21/65

Abstract: A method of measuring Raman signals comprises: an analyte placing step of placing an analyte on a detection surface of a microstructure plate which generates an enhanced electric field when irradiated with excitation light; an irradiating step of irradiating the detection surface with the excitation light so that the enhanced electric field is generated around the detection surface and light is emitted from the analyte and the detection surface to be enhanced by the generated enhanced electric field; a Raman signal obtaining step of detecting the enhanced light to obtain a Raman signal emitted from the analyte and a background signal for use as a reference, the Raman signal and the background signal having respective intensities; and a normalizing step of normalizing the Raman signal from the analyte by dividing the intensity of the Raman signal from the analyte by the intensity of the background signal obtained as the reference.

Abstract translation: 测量拉曼信号的方法包括：分析物放置步骤，将分析物放置在微细板的检测表面上，当用激发光照射时产生增强的电场; 照射步骤，用激发光照射检测面，使得在检测面周围产生增强的电场，并且从分析物和检测面发射光，通过产生的增强电场来增强; 拉曼信号获取步骤，检测增强光以获得从分析物发射的拉曼信号和用作参考的背景信号，拉曼信号和背景信号具有各自的强度; 以及归一化步骤，通过将来自分析物的拉曼信号的强度除以作为参考获得的背景信号的强度，将来自分析物的拉曼信号归一化。

公开(公告)号：US20120156714A1

公开(公告)日：2012-06-21

申请号：US13393960

申请日：2010-09-03

Applicant: Jeremiah O'Brien ,  Lee Barry

Inventor： Jeremiah O'Brien ,  Lee Barry

IPC: C12M1/34 ,  G01N21/17

CPC classification number: G01N15/1434 ,  G01J3/2803 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/1213 ,  G01N15/1436 ,  G01N15/1459 ,  G01N21/6428 ,  G01N2021/6482 ,  G02B5/201 ,  G02B5/288

Abstract: The invention provides a flow cytometric system comprising a first sensor positioned axially to a light source; a channel comprising means for receiving a sample target and interposed between said first sensor and light source; and a second sensor placed at an angle to said first sensor adapted to sense side scattering and/or fluorescent components and said first sensor is adapted to sense a forward scattering component in response to light illuminating the sample target in said channel. In another embodiment the invention provides for a wide dynamic range sensor comprising a plurality of photodiode pixels; wherein at least one or more of said photodiode pixels are voltage biased in one or more of the following modes: photon counting, normal, linear avalanche or Geiger modes, for wide dynamic sensor range operation. By altering the reverse bias voltage, thus putting each photodiode into one of normal, avalanche or Geiger mode, the dynamic range of incident scattering and fluorescent power to which the filter cell array is sensitive to is greatly increased, thus increasing the operational sensitivity and specificity of the cytometric instrument.

Abstract translation: 本发明提供一种流式细胞术系统，其包括轴向定位于光源的第一传感器; 通道，包括用于接收样本目标并插入在所述第一传感器和光源之间的装置; 以及适于感测侧面散射和/或荧光部件的与所述第一传感器成角度设置的第二传感器，并且所述第一传感器适于响应于照射所述通道中的样本目标的光而感测前向散射分量。 在另一个实施例中，本发明提供了一种包括多个光电二极管像素的宽动态范围传感器; 其中至少一个或多个所述光电二极管像素以一种或多种以下模式进行电压偏置：用于宽动态传感器范围操作的光子计数，正常，线性雪崩或盖革格模式。 通过改变反向偏置电压，从而使每个光电二极管成为正常，雪崩或盖革模式之一，滤波器阵列敏感的入射散射和荧光功率的动态范围大大增加，从而提高了操作灵敏度和特异性 的细胞仪器。

公开(公告)号：US20120150028A1

公开(公告)日：2012-06-14

申请号：US13316703

申请日：2011-12-12

Applicant: Patrick J. Treado ,  John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

Inventor： Patrick J. Treado ,  John S. Maier ,  Shona Stewart ,  Jeffrey Cohen ,  Matthew Nelson

IPC: A61B6/00

CPC classification number: A61B5/0075 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4064 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/08

Abstract: System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.

Abstract translation: 使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。 用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。 使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。 肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。