公开(公告)号：US20180164214A1

公开(公告)日：2018-06-14

申请号：US15580265

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： Xavier Rottenberg

IPC: G01N21/59 ,  G01N21/31

CPC classification number: G01N21/59 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0457 ,  B01L2400/0487 ,  G01N21/31 ,  G01N21/3577 ,  G01N21/552 ,  G01N21/61 ,  G01N21/7746 ,  G01N2021/0346 ,  G01N2021/3137 ,  G01N2021/3166 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/066 ,  G01N2201/0873

Abstract: The present disclosure relates to a device for measuring an optical absorption property of a fluid as function of wavelength. The device comprises a broadband light source for emitting light, a plurality of integrated optical waveguides for guiding this light, and a light coupler for coupling the emitted light into the integrated optical waveguides such that the light coupled into each integrated optical waveguide has substantially the same spectral distribution. The device also comprises a microfluidic channel for containing the fluid, arranged such as to allow an interaction of the light propagating through each waveguide with the fluid in the microfluidic channel. Each integrated optical waveguide comprises an optical resonator for filtering the light guided by the waveguide according to a predetermined spectral component. The spectral component corresponding to each waveguide is substantially different from the spectral component corresponding to another of the waveguides.

公开(公告)号：US20180136126A1

公开(公告)日：2018-05-17

申请号：US15815914

申请日：2017-11-17

Applicant: PROMEGA CORPORATION

Inventor： ANDREA CHOW ,  IGOR PALGUYEV ,  ERIC HEINZ ,  BRUCE JOHNSON ,  THOMAS WILLSON ,  YARON KIDRON

IPC: G01N21/64 ,  G02B21/06

CPC classification number: G01N21/645 ,  G01N2021/6417 ,  G01N2021/6482 ,  G01N2201/062 ,  G01N2201/0631 ,  G01N2201/0633 ,  G01N2201/0642 ,  G01N2201/08 ,  G02B21/06

Abstract: An illumination apparatus for configuration with spectro-fluorometer system includes at least one light emitting diode (LED), a collimator, and a light guide. The at least one LED may be configured to emit light including a first beam-width angle. The collimator is optically coupled to the at least one LED. The collimator is configured to collimate the light emitted from the at least one LED to form a collimated light beam including a second beam-width angle and a first cross-sectional illumination intensity profile. The second beam-width angle may be less than the first beam-width angle. The light guide may be configured to alter a cross-sectional area of the collimated light beam and output a substantially homogenized light beam including a second cross-sectional illumination intensity profile with greater uniformity than the first cross-sectional illumination intensity profile.

公开(公告)号：US09945781B2

公开(公告)日：2018-04-17

申请号：US15407443

申请日：2017-01-17

Applicant: Pacific Biosciences of California, Inc.

Inventor： Aaron Rulison ,  Mark McDonald ,  Paul Lundquist

IPC: G01N21/64 ,  G02B27/10 ,  G02B5/04 ,  C12Q1/68

CPC classification number: G01N21/6452 ,  C12Q1/6874 ,  G01J3/2803 ,  G01J3/36 ,  G01N21/6428 ,  G01N21/75 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/0633 ,  G02B3/0056 ,  G02B3/0062 ,  G02B5/045 ,  G02B13/006 ,  G02B13/0065 ,  G02B13/0085 ,  G02B27/1013

Abstract: Apparatus, systems and methods for use in analyzing discrete reactions are provided. The analytical devices of the invention use an array of nanoscale regions (a chip) that has discrete patches, for example, patches of nanoscale regions. In some embodiments an analytical system is provided that has an analysis chip with an array of patches, each of the patches comprising nanoscale regions that emit fluorescent light when illuminated. The system has a two-dimensional (x, y) array of dichroic prisms, each prism comprising a dichroic element that diverts illumination light up in the z dimension of the array to a patch on the analysis chip above it. Each dichroic element transmits fluorescent light emitted by the patch that it illuminates, whereby the emitted light from each patch passes down through each dichroic prism. The analytical system also has a detector below the array of dichroic prisms that detects the transmitted fluorescent light. Such systems are useful for monitoring many analytical reactions at one time including single molecule sequencing reactions.

公开(公告)号：US09909992B2

公开(公告)日：2018-03-06

申请号：US15119055

申请日：2015-02-28

Applicant: IMEC VZW

Inventor： Pol Van Dorpe ,  Peter Peumans

IPC: G01J3/30 ,  G01N21/65 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/36 ,  G01J3/44 ,  G01J3/26 ,  G01N33/49 ,  G01J3/12

CPC classification number: G01N21/65 ,  A61B5/0066 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/443 ,  A61B2562/0233 ,  A61B2562/0238 ,  G01J1/0204 ,  G01J1/0425 ,  G01J1/0477 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0227 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0291 ,  G01J3/1895 ,  G01J3/26 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/1213 ,  G01N33/49 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636 ,  G02B6/0026 ,  G02B6/0031 ,  G02B6/0038 ,  G02B6/0048

Abstract: The present disclosure relates to systems, methods, and sensors configured to characterize a radiation beam. At least one embodiment relates to an optical system. The optical system includes an optical radiation guiding system. The optical radiation guiding system includes a collimator configured to collimate the radiation beam into a collimated radiation beam. The optical radiation guiding system also includes a beam shaper configured to distribute power of the collimated radiation beam over a discrete number of line shaped fields. A spectrum of the collimated radiation beam entering the beam shaper is delivered to each of the discrete number of line shaped fields. The optical system further includes a spectrometer chip. The spectrometer chip is configured to process the spectrum of the collimated radiation beam in each of the discrete number of line shaped fields coming from the beam shaper.

公开(公告)号：US20180011335A1

公开(公告)日：2018-01-11

申请号：US15694682

申请日：2017-09-01

Applicant: Integrated Plasmonics Corporation

Inventor： Michael Yagoda SHAGAM ,  Robert Joseph WALTERS

IPC: G02B27/46 ,  B23K26/402 ,  G01N21/31 ,  G01N21/25 ,  B23K26/384 ,  C25D5/02 ,  C23C14/34 ,  B23K103/18

CPC classification number: G02B27/46 ,  B23K26/384 ,  B23K26/402 ,  B23K2103/18 ,  B23K2103/50 ,  C23C14/34 ,  C25D5/02 ,  G01N21/255 ,  G01N21/31 ,  G01N2201/0633 ,  G01N2201/068

Abstract: A spatial filter is made by forming a structure comprising a focusing element and an opaque surface, the opaque surface being disposed remotely from the focusing element in substantially the same plane as a focal plane of the focusing element; and by forming a pinhole in the opaque surface at or adjacent to a focal point of the focusing element by transmitting a substantially collimated laser beam through the focusing element so that a point optimally corresponding to the focal point is identified on the opaque surface and imperfection of the focusing element, if any, is reflected on the shape and position of the pinhole so formed.

公开(公告)号：US20170370828A1

公开(公告)日：2017-12-28

申请号：US15194829

申请日：2016-06-28

Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION

Inventor： Arifin Arifin ,  Cheng-Gang Xie

IPC: G01N21/31 ,  G01N15/02 ,  G01P5/26

CPC classification number: G01N21/31 ,  G01N15/0205 ,  G01N15/06 ,  G01N21/359 ,  G01N21/532 ,  G01N2015/0011 ,  G01N2015/0053 ,  G01N2015/0693 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0694 ,  G01N2201/12 ,  G01N2201/1241 ,  G01P5/26

Abstract: An apparatus includes a pipe through which a multiphase fluid flows, with a transparent window structure formed in the pipe. A collimated light source emits light through the transparent window structure into the pipe having a wavelength at which a component of a desired phase of the multiphase fluid is absorptive. A photodetector is positioned such that the emitted light passes through the multiphase fluid in the pipe to impinge upon the photodetector. The photodetector has an actual dynamic range for collimated light detection. Processing circuitry is configured to continuously adjust a power of the collimated light source dependent upon an output level of the photodetector so as to cause measurement of the emitted light over an effective dynamic range greater than the actual dynamic range, and determine a property of the multiphase fluid as a function of the power of the collimated light source.

公开(公告)号：US20170261430A1

公开(公告)日：2017-09-14

申请号：US15240471

申请日：2016-08-18

Applicant: Tien-Ming CHOU

Inventor： Tien-Ming CHOU

IPC: G01N21/59 ,  G01V8/12

CPC classification number: G01N21/59 ,  G01D5/32 ,  G01F23/00 ,  G01F23/2921 ,  G01F23/2922 ,  G01N2201/0633 ,  G01V8/12

Abstract: A detecting apparatus includes a container, and a detecting device including a transmitting module and a receiving module. The transmitting module includes a light-emitting element provided at a first point of the container and operable to transmit a photo signal to propagate toward the container along an optical path. The receiving module includes a light-receiving element provided at a second point of the container and configured to receive the photo signal transmitted through the container. The receiving module is operable to determine whether a substance is present within the container based on receipt of the photo signal. An imaginary tangent plane tangent to the first point is not parallel to an imaginary tangent plane tangent to the second point.

公开(公告)号：US09726602B2

公开(公告)日：2017-08-08

申请号：US14439046

申请日：2013-10-28

Applicant: Commissariat A L'Energie Atomique Et Aux Energies Alternatives ,  Biomerieux

Inventor： Mathieu Dupoy ,  Mathieu Debourdeau ,  Frédéric Pinston

IPC: G01N21/47 ,  C12M1/22 ,  C12M1/34 ,  C12Q1/02

CPC classification number: G01N21/47 ,  C12M23/10 ,  C12M41/36 ,  C12Q1/02 ,  G01N21/4738 ,  G01N2201/022 ,  G01N2201/06113 ,  G01N2201/0633

Abstract: A method for observing biological species on a culture medium contained in a container having at least one translucent face, the method including the steps of: a) directing a light beam onto one portion of the translucent face, so as to define at least one illuminated region and at least one non-illuminated region of the face; and b) acquiring an image of a portion of the surface of the culture medium illuminated by the light beam, the acquisition being carried out through at least one of the non-illuminated regions of the translucent face and along an optical acquisition axis forming a non-zero angle (a) with the direction of propagation of the light beam.

公开(公告)号：US09581548B2

公开(公告)日：2017-02-28

申请号：US14430147

申请日：2013-09-23

Applicant: GE Healthcare Bio-Sciences Corp.

Inventor： Jeremy Cooper ,  William M. Dougherty

IPC: G01N21/64 ,  G02B21/14 ,  G02B21/16 ,  G02B21/36 ,  G01B11/00 ,  G02B21/06 ,  G02B27/58

CPC classification number: G01N21/6458 ,  G01B11/002 ,  G01N21/6486 ,  G01N2201/0633 ,  G01N2201/0636 ,  G02B21/06 ,  G02B21/14 ,  G02B21/16 ,  G02B21/361 ,  G02B21/365 ,  G02B21/367 ,  G02B27/58

Abstract: Methods and systems to resolve positions of sample components in fluorescence stochastic microscopy using three-dimensional structured illumination microscopy (“3D-SIM”) are disclosed. In one aspect, components of a sample specimen are labeled with fluorophores and weakly illuminated with a frequency of light to stochastically convert a subset of the fluorophores into an active state. The sample is then illuminated with a three-dimensional structured illumination pattern (“3D-SIP”) of excitation light that causes the activated fluorophores to fluoresce. As the 3D-SIP is incrementally moved within the volume of the sample and images are recorded, computational methods are used to process the images to locate and refine the locations of the activated fluorophores thereby generating a super-resolution image of sample components.

Abstract translation: 公开了使用三维结构照明显微镜（“3D-SIM”）在荧光随机显微镜中分析样品组分位置的方法和系统。 在一个方面，样品样品的成分用荧光团标记，并以光的频率被弱照射以将一部分荧光团随机转化为活性状态。 然后用引起活化的荧光团发荧光的激发光的三维结构照明模式（“3D-SIP”）照亮样品。 随着3D-SIP在样本的体积内逐渐移动并且记录图像，使用计算方法来处理图像以定位和细化活化的荧光团的位置，从而生成样品组分的超分辨率图像。

公开(公告)号：US09574956B2

公开(公告)日：2017-02-21

申请号：US14405938

申请日：2013-06-06

Applicant: Technical University of Denmark

Inventor： Kasper Reck ,  Christian Østergaard ,  Ole Hansen ,  Erik Vilain Thomsen

IPC: G01L1/24 ,  G01L11/02 ,  G01N21/55 ,  G02B6/10

CPC classification number: G01L1/246 ,  G01L11/02 ,  G01N21/55 ,  G01N2201/061 ,  G01N2201/0633 ,  G01N2201/084 ,  G02B6/10

Abstract: The present invention relates to an all-optical sensor utilizing effective index modulation of a waveguide and detection of a wavelength shift of reflected light and a force sensing system accommodating said optical sensor. One embodiment of the invention relates to a sensor system comprising at least one multimode light source, one or more optical sensors comprising a multimode sensor optical waveguide accommodating a distributed Bragg reflector, at least one transmitting optical waveguide for guiding light from said at least one light source to said one or more multimode sensor optical waveguides, a detector for measuring light reflected from said Bragg reflector in said one or more multimode sensor optical waveguides, and a data processor adapted for analyzing variations in the Bragg wavelength of at least one higher order mode of the reflected light.

Abstract translation: 本发明涉及利用波导的有效折射率调制和检测反射光的波长偏移的全光学传感器以及容纳所述光学传感器的力感测系统。 本发明的一个实施例涉及包括至少一个多模光源的传感器系统，一个或多个光学传感器，其包括容纳分布式布拉格反射器的多模传感器光波导，至少一个发射光波导，用于引导来自所述至少一个光的光 源到所述一个或多个多模传感器光波导，用于测量在所述一个或多个多模传感器光波导中从所述布拉格反射器反射的光的检测器，以及适于分析至少一个高阶模的布拉格波长的变化的数据处理器 的反射光。