公开(公告)号：US20120268584A1

公开(公告)日：2012-10-25

申请号：US13535468

申请日：2012-06-28

Applicant: GAUDENZ DANUSER ,  PAUL C. GOODWIN

Inventor： GAUDENZ DANUSER ,  PAUL C. GOODWIN

IPC: H04N7/18

CPC classification number: G01N21/6428 ,  G01N21/636 ,  G01N21/6458 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2201/126 ,  G02B21/365 ,  G02B21/367 ,  G06T3/4053

Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.

Abstract translation: 本发明的实施例涉及成像技术，特别涉及一种随时间检测相对较弱信号的成像系统，并且使用所检测的信号来确定信号发射器的位置。 本发明的具体实施方案涉及用于成像荧光团标记的样品的方法和系统，以便以明显大于与光学显微镜相关联的衍射限制分辨率的分辨率产生样品的图像。 本发明的实施例采用重叠 - 发射 - 图像消歧以允许从密集布置的发射器收集数据，这显着减少用于产生中间图像的数据收集时间以及计算构建高分辨率所需的中间图像的数量 最终图像。 本发明的另外的实施例采用分层图像处理技术来进一步解析和解释消歧图像。

公开(公告)号：US08263897B2

公开(公告)日：2012-09-11

申请号：US12343034

申请日：2008-12-23

Applicant: Peter J. Morrisroe

Inventor： Peter J. Morrisroe

IPC: B23K10/00

CPC classification number: G01N21/73 ,  G01J3/443 ,  G01N21/68 ,  G01N2201/126 ,  H01J49/105

Abstract: A device for sustaining a plasma in a torch is provided. In certain examples, the device comprises a first electrode configured to couple to a power source and constructed and arranged to provide a loop current along a radial plane of the torch. In some examples, the radial plane of the torch is substantially perpendicular to a longitudinal axis of the torch.

Abstract translation: 提供了一种用于在割炬中维持等离子体的装置。 在某些示例中，该装置包括被配置为耦合到电源并被构造和布置成沿着焊炬的径向平面提供回路电流的第一电极。 在一些示例中，焊炬的径向平面基本上垂直于焊炬的纵向轴线。

公开(公告)号：US07995202B2

公开(公告)日：2011-08-09

申请号：US11704689

申请日：2007-02-09

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01J3/30

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

公开(公告)号：US20110014645A1

公开(公告)日：2011-01-20

申请号：US12785337

申请日：2010-05-21

Applicant: James Winkelman ,  Milenko Tanasijevic ,  David Zahniser

Inventor： James Winkelman ,  Milenko Tanasijevic ,  David Zahniser

IPC: C12Q1/04 ,  C12M1/36

CPC classification number: G01N15/1475 ,  G01N1/2813 ,  G01N1/312 ,  G01N21/255 ,  G01N33/49 ,  G01N35/00029 ,  G01N35/00871 ,  G01N35/1016 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1472 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2035/00138 ,  G01N2035/00465 ,  G01N2035/0091 ,  G01N2201/062 ,  G01N2201/126 ,  G01N2333/805 ,  G06K9/4652 ,  G06K9/6267 ,  G06T7/0012 ,  H04N5/2256 ,  H04N5/23293 ,  H04N5/265

Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.

Abstract translation: 公开了分析体液如血液和骨髓的系统和方法。 系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。

公开(公告)号：US20100315644A1

公开(公告)日：2010-12-16

申请号：US12756157

申请日：2010-04-07

Applicant: Richard Egan ,  Graham Lidgard ,  David Booker

Inventor： Richard Egan ,  Graham Lidgard ,  David Booker

IPC: G01N21/55

CPC classification number: G01N21/01 ,  G01N21/84 ,  G01N21/8483 ,  G01N33/487 ,  G01N2201/0446 ,  G01N2201/126 ,  G16H10/40 ,  Y02A90/26

Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.

Abstract translation: 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。

公开(公告)号：US20090166179A1

公开(公告)日：2009-07-02

申请号：US12343034

申请日：2008-12-23

Applicant: Peter Morrisroe

Inventor： Peter Morrisroe

IPC: H05H1/24 ,  B23K9/00

CPC classification number: G01N21/73 ,  G01J3/443 ,  G01N21/68 ,  G01N2201/126 ,  H01J49/105

Abstract: A device for sustaining a plasma in a torch is provided. In certain examples, the device comprises a first electrode configured to couple to a power source and constructed and arranged to provide a loop current along a radial plane of the torch. In some examples, the radial plane of the torch is substantially perpendicular to a longitudinal axis of the torch.

Abstract translation: 提供了一种用于在割炬中维持等离子体的装置。 在某些示例中，该装置包括被配置为耦合到电源并被构造和布置成沿着焊炬的径向平面提供回路电流的第一电极。 在一些示例中，焊炬的径向平面基本上垂直于焊炬的纵向轴线。

公开(公告)号：US07545487B2

公开(公告)日：2009-06-09

申请号：US11575125

申请日：2005-09-05

Applicant: Hugo L. Kok ,  Jan Hordijk

Inventor： Hugo L. Kok ,  Jan Hordijk

IPC: A01K43/00 ,  G01N33/08

CPC classification number: G01N21/314 ,  G01N33/085 ,  G01N2021/3137 ,  G01N2021/3166 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/0625 ,  G01N2201/1211 ,  G01N2201/1245 ,  G01N2201/126 ,  G01N2201/12715

Abstract: The invention relates to a device for inspecting eggs for the presence of blood. The device comprises a light source in order to pass light at a first wavelength which is not selectively absorbed by blood and light at a second wavelength which is selectively absorbed by blood through an egg to be inspected. Furthermore, the device comprises detection means for converting the light transmission through the egg to be inspected for each of the two wavelengths into corresponding signals, each of the said signals being representative of the light transmission at the relevant wavelength. The device also comprises signal-processing means which are transmission associated with the first wavelength and the light transmission associated with the second wavelength based on the signals emanating from the detection means and to emit a decision signal which is representative of the decision whether or not an egg contains blood on the basis of this ratio. According to the invention, the light source comprises one or more identical LED's (Light Emitting Diode) for generating light which passes through the egg. In use the one or more LED's emit light within a certain narrow spectrum, which spectrum comprises both the first and the second wavelength.

Abstract translation: 本发明涉及一种用于检查卵存在血液的装置。 该装置包括光源，以便以不被血液选择性地吸收的第一波长的光和通过待检查的卵选择性地被血液吸收的第二波长的光通过。 此外，该装置包括检测装置，用于将通过要检测的两个波长中的每一个的卵的光透射转换成相应的信号，所述信号中的每一个代表在相关波长处的光透射。 该装置还包括基于从检测装置发出的信号而与第一波长相关联的传输和与第二波长相关的光传输的信号处理装置，并且发出代表该决定的决定信号 在这个比例的基础上，鸡蛋含有血液。 根据本发明，光源包括用于产生通过蛋的光的一个或多个相同的LED（发光二极管）。 在使用中，一个或多个LED在特定窄谱内发光，该光谱包括第一和第二波长。

公开(公告)号：US5017787A

公开(公告)日：1991-05-21

申请号：US429583

申请日：1989-10-31

Applicant: Kiyomi Sato ,  Yasuo Saito

Inventor： Kiyomi Sato ,  Yasuo Saito

IPC: G01N21/31 ,  G01N21/3554

CPC classification number: G01N21/3554 ,  G01N21/314 ,  G01N21/359 ,  G01N21/4738 ,  G01N2201/1211 ,  G01N2201/126

Abstract: A desk-top type infrared radiation moisture measuring apparatus is of a type in which the moisture in a specimen is exposed to a measurement light easily absorbed into water and to at least one reference light not noticeably absorbed into water and calculation is performed to determine the moisture in the specimen on the basis of both the measurement light and the reference light, reflected from the specimen. The apparatus comprises a turntable on which the specimen is placed and which is exposed to both the measurement light and the reference light from above at a portion away from the center thereof, and a drive source for driving the turntable into rotation. The measurement is carried out while the turntable is being rotated.

Abstract translation: 台式红外线辐射水分测量装置是将样品中的水分暴露于容易吸收到水中的测量光和至少一个不明显地吸收到水中的参考光，并进行计算以确定 基于从样本反射的测量光和参考光的样本中的水分。 所述装置包括转台，所述转台在所述转台上放置所述样本并且在远离其中心的部分处从所述测量光和参考光暴露于所述参考光;以及用于驱动所述转台旋转的驱动源。 在转盘旋转时进行测量。

公开(公告)号：US4943142A

公开(公告)日：1990-07-24

申请号：US365320

申请日：1989-06-13

Applicant: Fredric S. Fay ,  Kevin E. Fogarty ,  Cyril Rodgers

Inventor： Fredric S. Fay ,  Kevin E. Fogarty ,  Cyril Rodgers

IPC: G01J1/44 ,  G01J3/12 ,  G01N21/64 ,  G02B7/00 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G02B21/06 ,  G02B26/007 ,  G01J2001/442 ,  G01J2001/4453 ,  G01J2003/123 ,  G01N2021/6421 ,  G01N21/6428 ,  G01N2201/126

Abstract: A microscope is modified to allow for precise imaging of samples using different filters at different focal planes under computer control. A filter accessory includes a filter disc having bandpass filters. The filter disc may be rotated to move a selected filter into the optical path between a light source and the microscope sample. Adjustment of the image plane of the microscope is controlled by the computer using feedback from a lens position sensor.

Abstract translation: 显微镜被修改为允许在计算机控制下在不同焦平面处使用不同滤光片的样品的精确成像。 过滤器附件包括具有带通滤波器的滤光片。 可以旋转滤光盘以将选定的滤光片移动到光源和显微镜样品之间的光路中。 显微镜的图像平面的调整由计算机使用来自透镜位置传感器的反馈来控制。

公开(公告)号：US4893935A

公开(公告)日：1990-01-16

申请号：US234367

申请日：1988-08-19

Applicant: William R. Mandel ,  Anthony J. Dekovich

Inventor： William R. Mandel ,  Anthony J. Dekovich

IPC: G01N15/14 ,  C12M1/34 ,  C12Q1/06 ,  G01N21/53 ,  G01N21/82 ,  G01N21/85

CPC classification number: G01N21/534 ,  C12M41/36 ,  G01N21/8507 ,  G01N21/82 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/126 ,  G01N2201/12753

Abstract: This invention relates to an apparatus, method and system for directly obtaining the optical density of a dynamic biological system over the wide operating range and a wide range of organism mass, compensating for the primary interference factor, agitation and gas bubble formation, and thereby obtaining a on-line real time monitoring of cell density to follow the product concentration and progress of the biological reaction system.

Abstract translation: 本发明涉及一种用于直接获得动态生物系统的光密度的装置，方法和系统，该动态生物系统在广泛的工作范围和广泛的生物质量范围内，补偿了主干涉因子，搅动和气泡形成，从而获得 在线实时监测细胞密度，跟随生物反应体系的产物浓度和进展。