公开(公告)号：US20090091614A1

公开(公告)日：2009-04-09

申请号：US11914347

申请日：2006-03-07

Applicant: Kazuhiro Gono ,  Shoichi Amano ,  Tomoya Takahashi ,  Mutsumi Ohshima

Inventor： Kazuhiro Gono ,  Shoichi Amano ,  Tomoya Takahashi ,  Mutsumi Ohshima

IPC: A61B1/06

CPC classification number: G01J3/50 ,  A61B1/00186 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/7203 ,  G01J3/32 ,  G01J3/501 ,  G01J3/513 ,  G01J2003/1213 ,  G01J2003/1221 ,  G01N21/255 ,  G01N2201/08 ,  G01N2201/0846 ,  G02B23/2446 ,  G02B23/2469 ,  H04N2005/2255

Abstract: A biological observation apparatus comprising: an illuminating section that irradiates light to a living body that is a subject to be examined; an image pickup section that photoelectrically converts light reflected from the living body based on the irradiating light and creates an image pickup signal; and a signal processing control section that controls operations of the illuminating section and/or the image pickup section and outputs the image pickup signal to a display device, wherein the signal processing control section includes: a spectral signal creating section that creates a spectral signal corresponding to an optical wavelength narrowband image from the image pickup signal through signal processing; and a color adjusting section that, when outputting the spectral signal to the display device, allocates a different color tone for each of a plurality of bands forming the spectral signal, further wherein the biological observation apparatus further comprises an image quality adjusting section that adjusts an image quality of a signal to be outputted to the display device, or, with the exception of at least the spectral signal creating section and the color adjusting section, the other signal processing sections are shared for respective signal processing on the image pickup signal and on the spectral signal.

Abstract translation: 一种生物观察装置，其特征在于，包括：照射部，其将光照射到作为被检体的生物体; 摄像部，其根据所述照射光对从所述生物体反射的光进行光电转换，并产生摄像信号; 信号处理控制部分，其控制照明部分和/或图像拾取部分的操作，并将图像拾取信号输出到显示装置，其中信号处理控制部分包括：频谱信号产生部分，其产生相应的频谱信号 通过信号处理从图像拾取信号到光波长窄带图像; 以及颜色调整部，其在向所述显示装置输出所述频谱信号时，为形成所述频谱信号的多个频带中的每一个分配不同的色调，其中，所述生物观察装置还包括图像质量调整部， 要输出到显示装置的信号的图像质量，或者除了至少频谱信号产生部分和颜色调整部分之外，其他信号处理部分被共享用于对摄像信号的各个信号处理， 光谱信号。

公开(公告)号：US07499806B2

公开(公告)日：2009-03-03

申请号：US10504568

申请日：2003-02-14

Applicant: Bahram Ghaffarzadeh Kermani ,  Juergen Haas

Inventor： Bahram Ghaffarzadeh Kermani ,  Juergen Haas

IPC: G06F17/11 ,  G06F17/50 ,  C12Q1/68 ,  C12M1/00

CPC classification number: G01N21/6428 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N2021/7786 ,  G01N2201/0846 ,  G06T7/0012 ,  G06T7/337 ,  G06T2207/30072

Abstract: Described herein are methods for registering analytical images comprising obtaining an image of an array, wherein the image depicts fiducials that can be used to register the sequential images of the array by determining the average intensity of the fiducials and then positioning the sequential images such that the average intensity of the fiducials attains either a maximum or minimum value.

Abstract translation: 这里描述了用于登记分析图像的方法，包括获得阵列的图像，其中图像描绘了可以用于通过确定基准的平均强度来登记阵列的顺序图像的基准，然后定位顺序图像，使得 基准的平均强度达到最大值或最小值。

公开(公告)号：US07327454B2

公开(公告)日：2008-02-05

申请号：US11404485

申请日：2006-04-13

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测在生物传感器的表面上发生的生物化学相互作用的装置包括光源。 第一光纤耦合到光源并照亮生物传感器。 第二光纤检测从生物传感器反射的波长。 光谱仪确定来自生物传感器的反射信号的光谱。

公开(公告)号：US20080006775A1

公开(公告)日：2008-01-10

申请号：US11767382

申请日：2007-06-22

Applicant: Jose Arno ,  Paul Marganski ,  Robert Hillas ,  Steven Lurcott ,  Glenn Tom

Inventor： Jose Arno ,  Paul Marganski ,  Robert Hillas ,  Steven Lurcott ,  Glenn Tom

IPC: G01N21/00

CPC classification number: G01N21/05 ,  G01N21/3504 ,  G01N2021/178 ,  G01N2021/317 ,  G01N2201/0846

Abstract: Thermopile-based detection and monitoring/control systems are described, in applications such as inferring concentration of a multicomponent gas by sensing a tracer gas therein, utilizing fiber optic cables to provide multiple sensing paths in a cell, utilizing a modulated IR source switched in on/off cycles, verifying chemical reagent identities, and sensing of effluent following discharge from a contamination removal 8 element or cold trap. A thermopile infrared (TPIR) detector of highly compact character is described for such applications, and permits monitoring of species that may be problematic or otherwise deleterious in such environments. In one implementation, light source modulation and signal processing techniques are employed to improve signal to noise ratio and minimize calibration and complexity of the TPIR detector.

Abstract translation: 在基于热电堆检测和监测/控制系统的应用中，例如通过在其中感测示踪气体来推断多组分气体的浓度，利用光纤缆线在单元中提供多个感测路径，利用开启的调制IR源 /关闭循环，验证化学试剂标识，以及从排除污染物8元素或冷阱排出后的污染物检测。 对于这种应用描述了具有高度紧密特性的热电堆红外（TPIR）检测器，并且允许监视在这种环境中可能是有问题或其它有害的物种。 在一个实施方案中，采用光源调制和信号处理技术来提高信噪比并最小化TPIR检测器的校准和复杂性。

公开(公告)号：US20070252987A1

公开(公告)日：2007-11-01

申请号：US11506639

申请日：2006-08-18

Applicant: Brian Cunningham ,  Peter Li ,  Frank DiFilippi

Inventor： Brian Cunningham ,  Peter Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测在生物传感器的表面上发生的生物化学相互作用的装置包括光源。 第一光纤耦合到光源并照亮生物传感器。 第二光纤检测从生物传感器反射的波长。 光谱仪确定来自生物传感器的反射信号的光谱。

公开(公告)号：US20070205379A1

公开(公告)日：2007-09-06

申请号：US11712917

申请日：2007-03-02

Applicant: Matthew P. Nelson ,  Patrick J. Treado

Inventor： Matthew P. Nelson ,  Patrick J. Treado

IPC: G01J1/58 ,  G02B6/06 ,  G01B9/10 ,  G01N21/64 ,  F21V9/16

CPC classification number: G01J3/2803 ,  G01J3/0221 ,  G01J3/44 ,  G01N21/474 ,  G01N21/55 ,  G01N21/645 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/0846 ,  G02B6/06

Abstract: The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.

Abstract translation: 本公开一般涉及使用用于改进样品的成像，光谱分析和交互式探测的光纤阵列基于光谱转换器的（“FAST”）光谱系统的方法和装置。 在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。 可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。

公开(公告)号：US20070081156A1

公开(公告)日：2007-04-12

申请号：US11544648

申请日：2006-10-10

Applicant: Patrick Treado ,  Thomas Voigt ,  Wesley Hutchison

Inventor： Patrick Treado ,  Thomas Voigt ,  Wesley Hutchison

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0227 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0286 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/447 ,  G01N2021/656 ,  G01N2201/0846

Abstract: The disclosure relates to a portable and/or handheld bioagent detector and methodology described herein that is based in part on advanced Raman Chemical Imaging (“RCI”) technology. According to one embodiment of the present disclosure, the detection system may include a fiber array spectral translator (“FAST”) and may also include a probe which may include a complementary metal oxide semiconductor (CMOS) camera. The probe alleviates the need to place the main instrument close to an unconfined release of a potentially hazardous material and facilitates analysis of a sample that is situated in a hard-to-reach location while minimizing contamination of the detector and operator.

Abstract translation: 本公开涉及部分基于先进的拉曼化学成像（“RCI”）技术的本文描述的便携式和/或手持式生物代谢检测器和方法。 根据本公开的一个实施例，检测系统可以包括光纤阵列光谱转换器（“FAST”），并且还可以包括可以包括互补金属氧化物半导体（CMOS）照相机的探针。 探头减轻了将主仪器置于非限制性释放潜在危险物质的需要，并有助于分析位于难以到达的位置的样品，同时最大限度地减少检测器和操作者的污染。

公开(公告)号：US07190457B2

公开(公告)日：2007-03-13

申请号：US10758318

申请日：2004-01-13

Applicant: Mary Elizabeth Tabacco ,  Marc W Mittelman ,  J. Anthony Schanzie

Inventor： Mary Elizabeth Tabacco ,  Marc W Mittelman ,  J. Anthony Schanzie

IPC: G01N21/25

CPC classification number: G01N21/8422 ,  G01N17/008 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/763 ,  G01N21/8507 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2021/8411 ,  G01N2021/8528 ,  G01N2201/0846 ,  G01N2201/1296

Abstract: Real time biofilm monitoring systems are provided. Said systems comprise single or multiple fiber-optic probes detecting wavelength-specific fluorescence from biomarkers of fouling organisms; a compact optoelectronic interface and data acquisition system interfaced with said probes, wherein said probe or probes are bifurcated and contain at least one excitation and at least one emission filter permitting the simultaneous resolution of multiple biomarkers.

Abstract translation: 提供实时生物膜监测系统。 所述系统包括检测来自污染生物体的生物标志物的波长特异性荧光的单个或多个光纤探针; 与所述探针接口的紧凑型光电接口和数据采集系统，其中所述探针或探针分叉并且包含至少一个激发和至少一个允许同时分辨多个生物标志物的发射过滤器。

公开(公告)号：US07158230B2

公开(公告)日：2007-01-02

申请号：US11404158

申请日：2006-04-13

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

Abstract translation: 用于检测生物分子相互作用的方法和装置。 不需要使用标签，并且可以以高通量的方式执行方法。 用于检测在生物传感器的表面上发生的生物化学相互作用的装置包括光源。 第一光纤耦合到光源并照亮生物传感器。 第二光纤检测从生物传感器反射的波长。 光谱仪确定来自生物传感器的反射信号的光谱。

公开(公告)号：US20050196317A1

公开(公告)日：2005-09-08

申请号：US11040504

申请日：2005-01-21

Applicant: David Walt ,  Todd Dickinson

Inventor： David Walt ,  Todd Dickinson

IPC: C12M1/34 ,  C40B60/14 ,  G01N21/64 ,  G01N21/77 ,  G01N33/00 ,  G01N33/543 ,  G01N21/00

CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。