公开(公告)号：US20200319108A1

公开(公告)日：2020-10-08

申请号：US16849102

申请日：2020-04-15

Applicant: Black Light Surgical, Inc. ,  Cedars-Sinai Medical Center

Inventor： Pramod Butte ,  Keith Black ,  Jack Kavanaugh ,  Bartosz Bortnik ,  Zhaojun Nie

IPC: G01N21/64 ,  G01J3/44 ,  G01J3/02 ,  G01J3/32 ,  G01J3/28 ,  G01J3/10

Abstract: Provided herein are devices, systems, and methods for characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy. A light source generates a light pulse or continuous light wave and excites the biological sample, inducing a responsive fluorescent signal. A demultiplexer splits the signal into spectral bands and a time delay is applied to the spectral bands so as to capture data with a detector from multiple spectral bands from a single excitation pulse. The biological sample is characterized by analyzing the fluorescence intensity magnitude and/or decay of the spectral bands. The sample may comprise one or more exogenous or endogenous fluorophore. The device may be a two-piece probe with a detachable, disposable distal end. The systems may combine fluorescence spectroscopy with other optical spectroscopy or imaging modalities. The light pulse may be focused at a single focal point or scanned or patterned across an area.

公开(公告)号：US10753874B2

公开(公告)日：2020-08-25

申请号：US15758079

申请日：2016-09-07

Applicant: MOBILEODT LTD.

Inventor： David Levitz ,  Ariel Beery ,  Ronit Slyper

IPC: G01N21/64 ,  G01N21/21 ,  G06T7/00 ,  G01N21/47 ,  G01J3/02 ,  G01J3/32 ,  G01J3/10 ,  G01J3/42 ,  G01J3/28 ,  A61B5/00 ,  H04N5/225 ,  H04N5/445

Abstract: A system including: a mobile device, including: a camera configured to capture multiple images of a subject; a processor configured to identify a first image of the captured images as a blue frame, wherein the image was captured while the subject was illuminated by blue light, and identify a second image of one of the captured images as a white frame, wherein the image was captured while the subject was illuminated by white light; associate the blue frame with the white frame; detect a feature depicted in the blue frame that is not depicted in the associated white frame, and indicate the detection of the feature to a user; and a user interface display configured to separately render the blue frame and the white frame.

公开(公告)号：US10684224B2

公开(公告)日：2020-06-16

申请号：US15316453

申请日：2015-06-03

Applicant: Universität Heidelberg

Inventor： Nikolas Dimitriadis ,  Nikolaos Deliolanis

IPC: G01N21/64 ,  G01N21/91 ,  G01J3/44 ,  A61B1/04 ,  A61B1/06 ,  A61B5/00 ,  G01J3/10 ,  G01N21/80 ,  G01J3/32 ,  A61B5/1455 ,  A61B3/14

Abstract: Multispectral imaging of samples, in particular of biological tissues. A method for acquisition of fluorescence images and reflection images of an object including alternatingly illuminating the object with at least a first light and a second light, wherein the first light and the second light are spectrally shaped such that at least one light has several spectral regions of high light intensity separated by spectral region(s) of low light intensity, wherein the spectral regions of the first light and the second light with high intensity at least partially do not overlap and wherein at least one of the two lights has at least one region of low light intensity that is of longer wavelength to the neighboring region of high light intensity, and recording at least a first image of the object and a second image of the object while illuminating the object with at least one of the lights.

公开(公告)号：US10648960B2

公开(公告)日：2020-05-12

申请号：US15166092

申请日：2016-05-26

Applicant: REBELLION PHOTONICS, INC.

Inventor： Robert Timothy Kester ,  Nathan Adrian Hagen

IPC: G01N33/00 ,  H04N5/33 ,  H04N5/225 ,  G01N21/3504 ,  G01J5/00 ,  G01J3/28 ,  G01J3/32 ,  G01J3/36 ,  G01J5/52 ,  G01J3/02 ,  G01J5/08 ,  H04N17/00 ,  G01J5/60 ,  G01J3/42 ,  G01J3/12

Abstract: Various embodiments disclosed herein describe an infrared (IR) imaging system for detecting a gas. The imaging system can include an optical filter that selectively passes light having a wavelength in a range of 1585 nm to 1595 nm while attenuating light at wavelengths above 1600 nm and below 1580 nm. The system can include an optical detector array sensitive to light having a wavelength of 1590 that is positioned rear of the optical filter.

公开(公告)号：US10648861B2

公开(公告)日：2020-05-12

申请号：US15908455

申请日：2018-02-28

Applicant: VERIFOOD, LTD.

Inventor： Damian Goldring ,  Dror Sharon ,  Guy Brodetzki ,  Sagee Rosen ,  Omer Keilaf ,  Uri Kinrot ,  Ittai Nir ,  Nitzan Waisberg ,  Ofer Rachman ,  Assaf Carmi

IPC: G01J3/02 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/06 ,  G01J3/32 ,  G01J3/36

Abstract: A protective sheath having a closed end and an open end is sized to receive a hand held spectrometer. The spectrometer can be placed in the sheath to calibrate the spectrometer and to measure samples. In a calibration orientation, an optical head of the spectrometer can be oriented toward the closed end of the sheath where a calibration material is located. In a measurement orientation, the optical head of the spectrometer can be oriented toward the open end of the sheath in order to measure a sample. To change the orientation, the spectrometer can be removed from the sheath container and placed in the sheath container with the calibration orientation or the measurement orientation. Accessory container covers can be provided and placed on the open end of the sheath with samples placed therein in order to provide improved measurements.

公开(公告)号：US20200088577A1

公开(公告)日：2020-03-19

申请号：US16689802

申请日：2019-11-20

Applicant: Hitachi High-Technologies Corporation

Inventor： Kei Shimura ,  Mizuki OKU ,  Kenji AIKO

IPC: G01J3/10 ,  G02F1/39 ,  G01J3/02 ,  G01J3/32 ,  G01N21/3581 ,  G01J3/42 ,  G02F1/37

Abstract: This far-infrared spectroscopy device is provided with: a variable wavelength far-infrared light source that generates first far-infrared light; an illuminating optical system that irradiates a sample with the first far-infrared light; a detecting nonlinear optical crystal that converts second far-infrared light into near-infrared light using pump light, said second far-infrared light having been transmitted from the sample; and a far-infrared image-forming optical system that forms an image of the sample in the detecting nonlinear optical crystal. The irradiation position of the first far-infrared light on the sample does not depend on the wavelength of the first far-infrared light.

公开(公告)号：US20180238794A1

公开(公告)日：2018-08-23

申请号：US15751095

申请日：2016-08-29

Applicant: Apple Inc.

Inventor： Miikka M. KANGAS ,  Mark Alan ARBORE ,  David I. SIMON ,  Michael J. BISHOP ,  James W. HILLENDAHL ,  Robert CHEN

IPC: G01N21/27 ,  G01J3/02 ,  G01J3/32 ,  G01J3/36 ,  G01J3/433 ,  G01J3/447 ,  G01N21/47 ,  G01N21/35

Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.

公开(公告)号：US09958325B2

公开(公告)日：2018-05-01

申请号：US15624008

申请日：2017-06-15

Applicant: Metal Power Analytical (I) Pvt. Ltd.

Inventor： Priyadarshan Divyadarshan Pant

IPC: G01J3/28 ,  G01J3/06 ,  G01J3/02 ,  G01J3/04 ,  G01J3/443 ,  G01N21/31 ,  G01N21/33 ,  G01J3/18 ,  G01J3/32

CPC classification number: G01J3/06 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/04 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/443 ,  G01J2003/045 ,  G01J2003/061 ,  G01J2003/065 ,  G01J2003/282 ,  G01N21/3103 ,  G01N21/33 ,  G01N2201/0826

Abstract: The present disclosure relates to the field of optical systems. The envisaged multi-scan optical system is compact and stable. The system comprises an excitation source, a hydra fiber cable, a wavelength selector, an optical element, and a detector. The excitation source is configured to emit composite light. The hydra fiber cable has a head and a plurality of tentacles, and is configured to receive the composite light via a second lens. The plurality of tentacles is configured to emit the composite light towards the wavelength selector which includes a plurality of optical slits (s1-s8) and a plurality of shutters. The wavelength selector is configured to selectively collect and filter the composite light directed by a first lens and the plurality of tentacles by means of the plurality of shutters. The detector is configured to detect the plurality of spectral line scans reflected by the optical element for spectrometric analysis.

公开(公告)号：US20170356847A1

公开(公告)日：2017-12-14

申请号：US15651695

申请日：2017-07-17

Applicant: IFE Innovative Forschungs- und Entwicklungs GmbH & Co. KG

Inventor： Thomas Willuweit ,  Ralf Griesbach

IPC: G01N21/64 ,  G01J3/02 ,  G01N21/25 ,  G01J3/32 ,  G01J3/10 ,  G01J3/28 ,  G01J3/44

CPC classification number: G01N21/64 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/28 ,  G01J3/32 ,  G01J3/4406 ,  G01N21/251 ,  G01N21/645 ,  G01N2201/024 ,  G01N2201/08

Abstract: The invention provides a measuring device for analyzing a luminescent sample and, in particular, for measuring the concentration of at least one analyte in a luminescent sample, comprising: a housing with a sample receptacle space for accommodating a sample container; a sample container for accommodating the luminescent sample; a radiation receiver apparatus for receiving radiation emitted by the luminescent sample; and an evaluation apparatus for evaluating the radiation from the luminescent sample received by the radiation receiver apparatus. The invention moreover provides a measuring device comprising a base part and a measuring head arranged at the base part in an interchangeable manner, wherein the measuring head is embodied to analyze the luminescent sample or it is embodied as a spectrometer measuring head.

公开(公告)号：US20170343477A1

公开(公告)日：2017-11-30

申请号：US15607457

申请日：2017-05-27

Applicant: Verily Life Sciences LLC

Inventor： Charles Santori ,  Supriyo Sinha ,  Cheng-Hsun Wu ,  James Higbie ,  Seung Ah Lee

IPC: G01N21/64 ,  A61B5/00 ,  G01J3/32 ,  G01J3/44

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/433 ,  G01J3/4406 ,  G01J2003/1243 ,  G01N21/6408 ,  G01N21/6445 ,  G01N21/6458 ,  G01N2021/6471 ,  G01N2201/0675 ,  G02B21/004 ,  G02B21/0076 ,  G02B21/16

Abstract: Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths, and a first set of optical elements that include a first spatial light modulator (SLM), at least one lens, and at least one dispersive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.