Assembling method of spectrometer and assembling system

    公开(公告)号:US09891103B2

    公开(公告)日:2018-02-13

    申请号:US15003795

    申请日:2016-01-21

    Abstract: A spectrometer comprising a waveguide module, a diffractive component, and a light sensor is provided. The waveguide module has a first reflective surface, a second reflective surface opposite to the first reflective surface, and a light channel between the first reflective surface and the second reflective surface. The diffractive component has a diffractive surface and a plurality of strip-shaped diffractive structures located on the diffractive surface. The sharpness of the profile of the strip-shaped diffractive structures on a first side of the diffractive surface is greater than that on a second side of the diffractive surface. When viewed along a direction perpendicular to the second reflective surface, the first side of the diffractive surface is positioned between the first reflective surface and the second reflective surface with a distance away from the second reflective surface. A method for assembling the spectrometer and an assembling system are also provided.

    Accuracy and precision in raman spectroscopy

    公开(公告)号:US09689743B2

    公开(公告)日:2017-06-27

    申请号:US13559211

    申请日:2012-07-26

    CPC classification number: G01J3/0248 G01J3/0237 G01J3/0278 G01J3/44 G01N21/65

    Abstract: The disclosure is related systems and method for improved accuracy and precision in Raman spectroscopy. In one embodiment, a device may comprise a Raman spectroscopic apparatus configured to determine a property of a sample by directing photons at the sample and measuring a resulting Raman scattering, a positioning apparatus capable of manipulating a position of the sample, and the device being configured to selectively adjust a focus of the Raman spectroscopic apparatus to adjust an intensity of the Raman scattering. Another embodiment may be a method comprising performing a depth focus Raman spectra screening on a sample to determine a depth focus with a maximum-intensity Raman spectra, wherein the depth focus spectra screening comprises performing Raman spectra scans on the sample at a plurality of depth foci, and modifying a process based on a result of the Raman spectra scan at the depth focus with the maximum-intensity Raman spectra.

    ANGLED CONFOCAL SPECTROSCOPY
    209.
    发明申请

    公开(公告)号:US20160341668A1

    公开(公告)日:2016-11-24

    申请号:US15111894

    申请日:2015-01-15

    Abstract: Disclosed herein are systems and methods for performing angled confocal spectroscopy. Angled confocal spectroscopy permits sensitive, non-invasive investigation of numerous analytes in a wide variety of samples, including tissues and bodily fluids. The methods and systems disclosed herein can be used to measure spectroscopic signatures of analytes within well-defined and very small regions of samples, while at the same time achieving superior rejection of signal contributions from analytes within the sample that do not fall within a volume of interest. Accordingly, measurements can be performed at comparatively high signal-to-noise ratios, and can provide information such as concentrations and distributions of sample analytes at high spatial resolution. By using cylindrically-focused illumination light, samples can be excited by a “sheet” of light, allowing spatial signal averaging and enhancing the stability and reproducibility of the measurements.

    Abstract translation: 本文公开了用于进行角度共焦光谱的系统和方法。 角度共焦光谱法允许对各种样品(包括组织和体液)中的许多分析物进行敏感,非侵入性的研究。 本文公开的方法和系统可用于测量在定义良好且非常小的样品区域内的分析物的光谱特征,同时从样品内的分析物的信号贡献优先排除不属于 利益。 因此,可以在相对高的信噪比下进行测量,并且可以以高空间分辨率提供诸如样品分析物的浓度和分布的信息。 通过使用圆柱聚焦的照明光,可以通过“片”光来激发样品,从而允许空间信号平均并增强测量的稳定性和再现性。

    Systems and methods for determining biomechanical properties of the eye for applying treatment
    210.
    发明授权
    Systems and methods for determining biomechanical properties of the eye for applying treatment 有权
    用于确定眼睛施用治疗的生物力学性质的系统和方法

    公开(公告)号:US09498122B2

    公开(公告)日:2016-11-22

    申请号:US14308678

    申请日:2014-06-18

    Applicant: Avedro, Inc.

    Abstract: A system for determining biomechanical properties of corneal tissue includes a light source configured to provide an incident light and a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of corneal tissue. The incident light is reflected by the corneal tissue as scattered light. The system also includes a filter or attenuating device configured to block or attenuate the Rayleigh peak frequency of the scattered light, a spectrometer configured to receive the scattered light and process frequency characteristics of the received scattered light to determine a Brillouin frequency shift in response to the Rayleigh peak frequency being blocked or attenuated by the filter or attenuating device, and a processor configured to generate a three-dimensional profile of the corneal tissue according to the determined Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the corneal tissue.

    Abstract translation: 用于确定角膜组织的生物力学性质的系统包括被配置为提供入射光的光源和被配置为扫描穿过角膜组织的多个横截面的入射光的共焦显微镜系统。 入射光被角膜组织反射为散射光。 该系统还包括被配置为阻挡或衰减散射光的瑞利峰值频率的滤波器或衰减装置,被配置为接收散射光的光谱仪和接收的散射光的处理频率特性,以响应于所述散射光的布里渊频移来确定布里渊频移 瑞利峰值频率被滤波器或衰减装置阻挡或衰减,以及处理器,被配置为根据确定的布里渊频移产生角膜组织的三维轮廓。 三维轮廓提供角膜组织的一种或多种生物力学性质的指标。

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