公开(公告)号：US07477379B2

公开(公告)日：2009-01-13

申请号：US11819254

申请日：2007-06-26

Applicant: Ryoichi Ootani ,  Makoto Ishibashi

Inventor： Ryoichi Ootani ,  Makoto Ishibashi

IPC: G01J3/30

CPC classification number: G01N21/718 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/4406 ,  G01N21/6458

Abstract: Pulse laser light transmitted through a laser light transmission optical fiber to an optical system unit passes through a distribution reflecting mirror and is condensed by a condenser lens group. The condenser lens group irradiates the condensed laser light onto an analysis object. The fluorescence emitted as a result of the irradiation of the pulse laser light onto the analysis object is condensed by the condenser lens group and is reflected by the distribution reflecting mirror. The optical system unit transmits the fluorescence reflected by the distribution reflecting mirror through an fluorescence transmission optical fiber to a fluorescence measuring instrument. The fluorescence measuring instrument determines the quantity of elements included in the analysis object on the basis of the fluorescence.

Abstract translation: 通过激光传输光纤传输到光学系统单元的脉冲激光通过分布反射镜并被聚光透镜组聚光。 聚光透镜组将聚光激光照射到分析对象上。 作为将脉冲激光照射到分析对象上的结果发出的荧光由聚光透镜组会聚，并被分布反射镜反射。 光学系统单元通过荧光传输光纤将由分布反射镜反射的荧光发射到荧光测量仪器。 荧光测量仪器基于荧光确定分析对象中包含的元素的数量。

公开(公告)号：US07456950B2

公开(公告)日：2008-11-25

申请号：US11846508

申请日：2007-08-28

Applicant: Francis J. Deck ,  John Magie Coffin

Inventor： Francis J. Deck ,  John Magie Coffin

IPC: G01J3/02 ,  G02B17/00

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0262

Abstract: In a spectrometer, preferably in a spectrometric microscope, light from a specimen is collected at a collector objective element and delivered to a camera element, which in turn provides the light to a photosensitive detector. A focal plane is provided between the collector objective element and the camera element, and one or more aperture arrays may be situated in the focal plane to restrict the detector's field of view of the specimen to the areas within the apertures. By utilizing aperture arrays with apertures of different sizes and shapes, the spatial resolution of the spectrometer readings may be varied without the need to vary the optics of the spectrometer. As a result, if the optics are optimized to minimize vignetting, spatial resolution may be varied without adverse increases in vignetting.

Abstract translation: 在光谱仪中，优选在光谱显微镜中，将来自样本的光收集在收集器目标元件处并传送到相机元件，照相机元件又将光提供给光敏检测器。 焦平面设置在收集器目标元件和相机元件之间，并且一个或多个孔阵列可以位于焦平面中，以将检测器的视场的视野限制在孔内的区域内。 通过利用具有不同尺寸和形状的孔的孔径阵列，可以改变光谱仪读数的空间分辨率，而不需要改变光谱仪的光学器件。 结果，如果光学器件被优化以最小化渐晕，则可以改变空间分辨率而不增加渐晕。

公开(公告)号：US20080174763A1

公开(公告)日：2008-07-24

申请号：US11961456

申请日：2007-12-20

Applicant: Peter Ehbets ,  Adrian Kohlbrenner

Inventor： Peter Ehbets ,  Adrian Kohlbrenner

IPC: G01J3/00 ,  G01J4/00 ,  G01J3/447

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0213 ,  G01J3/024 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/50 ,  G01J3/501 ,  H04N1/00005 ,  H04N1/00015 ,  H04N1/00023 ,  H04N1/00045 ,  H04N1/00047 ,  H04N1/0005 ,  H04N1/00058

Abstract: A scanner device includes a support surface for the measured object and a drive unit for moving a color measuring head across the support surface in at least one dimension thereof and for adjusting the height of the color measuring head in the direction perpendicular to the support surface, as well as a measuring and drive control unit activating the drive unit and cooperating with the color measuring head (MH). The color measuring head (MH) is equipped with at least an illuminating channel (IC) and a collection channel (CC). The illuminating channel (IC) has a light source (10) and optical means (12-22) for illuminating the measured object (S) at a measurement site at a mean angle of incidence of 45 E. The collection channel (CC) has optical means (24-34) for capturing the light emanating from the measured object at the measurement site at a mean collection angle of 0 E and coupling it into a light guide (LF), which directs the captured measurement light to a wavelength-selective photoelectric transformer preferably provided in the form of a spectrometer, which resolves it into a number of wavelength ranges and generates an electric measurement signal corresponding to each wavelength range. The color measuring head is suitable for taking high-precision measurements of even the smallest measurement fields without contact.

Abstract translation: 扫描仪装置包括用于测量对象的支撑表面和用于在测量头的至少一个尺寸上跨过支撑表面移动测色头并用于在垂直于支撑表面的方向上调节测色头的高度的驱动单元， 以及启动驱动单元并与彩色测量头（MH）配合的测量和驱动控制单元。 彩色测量头（MH）至少配备有照明通道（IC）和收集通道（CC）。 照明通道（IC）具有光源（10）和光学装置（12-22），用于以平均入射角45°在测量部位照射测量对象（S）。收集通道（CC）具有 光学装置（24-34），用于以0E的平均收集角度捕获从测量部位发射的光的光，并将其耦合到导光体（LF）中，导光体将捕获的测量光引导到波长选择性 光电变压器优选以光谱仪的形式提供，其将其分解成多个波长范围，并产生对应于每个波长范围的电测量信号。 彩色测量头适用于即使是最小测量领域也不接触的高精度测量。

公开(公告)号：US20070263290A1

公开(公告)日：2007-11-15

申请号：US11744797

申请日：2007-05-04

Applicant: Patrick Treado ,  Matthew Nelson ,  Scott Keitzer ,  Ryan Smith

Inventor： Patrick Treado ,  Matthew Nelson ,  Scott Keitzer ,  Ryan Smith

IPC: G02B5/04 ,  G02B3/00 ,  G02B5/22

CPC classification number: G02B6/06 ,  A61B1/00165 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/44 ,  G01J2003/1213

Abstract: A fiberscope device is disclosed which is suitable for video imaging, laser Raman spectroscopy and laser Raman spectroscopic (i.e. chemical) imaging. The fiberscope design minimizes fiber background interference arising from the laser delivery fiber optic and the coherent fiber optic light gathering bundle while maintaining high light throughput efficiency through the use of integrated spectral filters. In the fiberscope design, the laser delivery fiber optic is offset from the coherent fiber optic light gathering bundle. The laser delivery field is captured entirely by the light gathering field of view of the coherent fiber bundle. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The fiberscope is suited to the analysis of a wide range of condensed phase materials (solids and liquids), including the analysis of biological materials such as breast tissue lesions and arterial plaques, in such a manner to delineate abnormal from normal tissues.

Abstract translation: 公开了适用于视频成像，激光拉曼光谱和激光拉曼光谱（即化学）成像的纤维内窥镜装置。 纤维镜设计可以最大限度地减少激光传输光纤和相干光纤采集光束产生的光纤背景干扰，同时通过使用集成光谱滤波器保持高光通量效率。 在纤维镜设计中，激光传输光纤与相干光纤聚光束偏移。 激光输送场完全由相干光纤束的聚光场捕获。 纤维镜包含光谱滤光器光学元件，其提供环境不敏感性，特别是对温度和湿度。 纤维内窥镜适用于分析各种凝聚相材料（固体和液体），包括分析生物材料如乳房组织损伤和动脉斑块，以便从正常组织中描绘异常。

公开(公告)号：US07286225B2

公开(公告)日：2007-10-23

申请号：US11289315

申请日：2005-11-30

Applicant: Naoshi Aikawa

Inventor： Naoshi Aikawa

IPC: G01J3/04 ,  G01J3/18 ,  G01N21/64

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/024 ,  G01J3/2803

Abstract: A spectroscope includes an optical fiber 218, a collimator optical system 231 for collimating signal light come out from the optical fiber 218, a spectroscopic element 233 for dispersing the signal light collimated by the collimator optical system 231, a detector 237 composed of a plurality of detector elements 237a disposed at least in a direction of dispersion and detecting the light dispersed by the spectroscopic element 233, and a focusing optical system 236 for focusing the signal light come out from the detector 237 onto a detecting surface of the detector 237. It is set such that the focusing optical system 236 makes a diameter of a spot of the signal light focused on the detecting surface of the detector 237 smaller than an arranged pitch of the detector 237 and a numerical aperture of the collimator optical system 231 is larger than that of the optical fiber 218.

Abstract translation: 分光镜包括光纤218，用于准直信号光从光纤218出来的准直光学系统231，用于分散由准直仪光学系统231准直的信号光的分光元件233，由多个 检测器元件237a至少设置在分散方向上并检测由分光元件233分散的光，以及用于聚焦信号光的聚焦光学系统236从检测器237出射到检测器237的检测表面上。 被设置为使得聚焦光学系统236使得聚焦在检测器237的检测表面上的信号光的点的直径小于检测器237的排列间距，并且准直仪光学系统231的数值孔径更大 比光纤218高。

公开(公告)号：US20070201022A1

公开(公告)日：2007-08-30

申请号：US11679112

申请日：2007-02-26

Applicant: Jason H. Neiss ,  Patrick J. Treado ,  Robert Schweitzer

Inventor： Jason H. Neiss ,  Patrick J. Treado ,  Robert Schweitzer

IPC: G01J3/00

CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/0833 ,  G01N2201/1293

Abstract: The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for performing spectral unmixing of a mixture containing multiple polymorphs. In an embodiment, a first spectrum of a mixture containing polymorphs of a compound is obtained using a photon detector and a fiber array spectral translator having plural fibers. A set of second spectra is provided where each spectrum of the set of second spectra may be representative of a different polymorph of the compound. The first spectrum and the set of second spectra may be compared, and based on the comparison, the presence of one or more polymorphs in the mixture may be determined.

Abstract translation: 本公开总体上涉及使用用于执行含有多个多晶型物的混合物的光谱解混合的光纤阵列光谱转换器（“FAST”）光谱系统的方法和装置。 在一个实施方案中，使用具有多个纤维的光子检测器和光纤阵列光谱转换器获得含有化合物多晶型物的混合物的第一光谱。 提供了一组第二光谱，其中该组第二光谱的每个光谱可以代表该化合物的不同多晶型物。 可以比较第一光谱和第二光谱集，并且基于比较，可以确定混合物中一个或多个多晶型物的存在。

公开(公告)号：US20070195323A1

公开(公告)日：2007-08-23

申请号：US10559175

申请日：2004-05-21

Applicant: Manfred Fritsch ,  Nico Correns ,  Felix Kerstan

Inventor： Manfred Fritsch ,  Nico Correns ,  Felix Kerstan

IPC: G01J3/28

CPC classification number: G01B11/306 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/024 ,  G01J3/0262 ,  G01J3/04 ,  G01J3/2803

Abstract: The invention is directed to an arrangement for detecting coatings which are arranged on surfaces of structural component parts or objects and for determining the chemical characteristics and surface properties of these coatings. It comprises a light source for illuminating the coating to be analyzed on the surface of the structural component part and means for imaging the light source on an entrance slit over the surface of the coating to be analyzed. The entrance slit is imaged in a wavelength-dependent manner on a two-dimensional detector unit by a grating. An evaluating unit which is electrically connected to the detector unit serves to evaluate and process the signals supplied by the exposed detector elements of the detector unit.

Abstract translation: 本发明涉及一种用于检测涂层的布置，其布置在结构部件或物体的表面上并用于确定这些涂层的化学特性和表面性质。 它包括用于照亮在结构部件表面上待分析的涂层的光源，以及用于将光源成像在待分析涂层的表面上的入口狭缝上的装置。 入射狭缝通过光栅以波长依赖的方式成像在二维检测器单元上。 电连接到检测器单元的评估单元用于评估和处理由检测器单元的暴露的检测器元件提供的信号。

公开(公告)号：US07230697B2

公开(公告)日：2007-06-12

申请号：US11040709

申请日：2005-01-20

Applicant: Mark F. Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

Inventor： Mark F. Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

IPC: G01J3/28

CPC classification number: G01N21/6458 ,  G01J3/0202 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/04 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/2889 ,  G01J3/36 ,  G01N2021/6423 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/024 ,  G01N2201/10 ,  G01N2201/103 ,  G02B21/26

Abstract: A method and apparatus is disclosed for multi-mode spectral imaging. In one embodiment, the present invention comprises the steps of illuminating an object with a modified illumination profile, producing a reflected, transmitted or fluorescence image of the illuminated object, scanning the object, and re-imaging the reflected, transmitted or fluorescence light after modifying the light's optical state. The present invention preferably works in conjunction with other imaging systems to provide both high-spectral resolution images with lower temporal resolution and multiple image acquisition with high temporal resolution.

Abstract translation: 公开了用于多模式光谱成像的方法和装置。 在一个实施例中，本发明包括以下步骤：用修改的照明轮廓照亮物体，产生被照射物体的反射，透射或荧光图像，扫描物体，以及在修改之后对反射的，透射的或荧光进行重新成像 光的光学状态。 本发明优选与其他成像系统结合使用，以提供具有较低时间分辨率的高光谱分辨率图像和具有高时间分辨率的多个图像采集。

公开(公告)号：US06943892B2

公开(公告)日：2005-09-13

申请号：US10763982

申请日：2004-01-23

Applicant: Winston Kong Chan

Inventor： Winston Kong Chan

IPC: G01B9/02

CPC classification number: G02B6/29346 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/26 ,  G01J3/45 ,  G01J3/4535

Abstract: An instrument including a scannable mirror employs multimode optical fibers and an optical coupler. Modal dispersion, e.g., from the multimode optical fiber, is reduced by a method employing deconvolution. The scannable mirror may employ a mirror movable in an optical waveguide or an optical fiber wound on an expandable core.

Abstract translation: 包括可扫描镜的仪器采用多模光纤和光耦合器。 通过采用去卷积的方法来减少来自多模光纤的模态色散。 可扫描镜可以使用可在光波导中移动的反射镜或缠绕在可扩展芯上的光纤。

公开(公告)号：US20050157294A1

公开(公告)日：2005-07-21

申请号：US11040709

申请日：2005-01-20

Applicant: Mark Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

Inventor： Mark Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

IPC: G01J3/04 ,  G01J3/10 ,  G01J3/28 ,  G01J3/30 ,  G01J3/36 ,  G01N21/64 ,  G02B21/26

CPC classification number: G01N21/6458 ,  G01J3/0202 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/04 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/2889 ,  G01J3/36 ,  G01N2021/6423 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/024 ,  G01N2201/10 ,  G01N2201/103 ,  G02B21/26

Abstract: A method and apparatus is disclosed for multi-mode spectral imaging. In one embodiment, the present invention comprises the steps of illuminating an object with a modified illumination profile, producing a reflected, transmitted or fluorescence image of the illuminated object, scanning the object, and re-imaging the reflected, transmitted or fluorescence light after modifying the light's optical state. The present invention preferably works in conjunction with other imaging systems to provide both high-spectral resolution images with lower temporal resolution and multiple image acquisition with high temporal resolution.

Abstract translation: 公开了用于多模式光谱成像的方法和装置。 在一个实施例中，本发明包括以下步骤：用修改的照明轮廓照亮物体，产生被照射物体的反射，透射或荧光图像，扫描物体，以及在修改之后对反射的，透射的或荧光进行重新成像 光的光学状态。 本发明优选与其他成像系统结合使用，以提供具有较低时间分辨率的高光谱分辨率图像和具有高时间分辨率的多个图像采集。