公开(公告)号：US20130169954A1

公开(公告)日：2013-07-04

申请号：US13751181

申请日：2013-01-28

Applicant: CIENCIA, INC.

Inventor： George N. Gibson ,  Ernest F. Guignon ,  Michael T. Reilly

IPC: G01N21/55

CPC classification number: G01N21/55 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/553 ,  G01N21/648 ,  G01N21/7743

Abstract: An instrument for measuring and analyzing surface plasmon resonance on a sensor surface has a polarized light source optically connected to the sensor surface by a plurality of optical elements, including in one embodiment an optical telescope that transfers light from a rotatable reflecting surface to the sensor surface. Selective positioning of a cylindrical lens into a first position within the path of light transforms collimated light to a rectangular wedge that is incident upon the sensor surface at numerous angles. In another embodiment, the light source is operated as a laser to excite fluorescence on the sensor surface and the fluorescence is selectively directed to a detector by appropriate optical elements positioned in specific configurations.

Abstract translation: 用于测量和分析传感器表面上的表面等离子体共振的仪器具有通过多个光学元件光学连接到传感器表面的偏振光源，在一个实施例中包括将光从可旋转反射表面传输到传感器表面的光学望远镜 。 将柱面透镜选择性地定位在光路内的第一位置将准直光转换成以多个角度入射在传感器表面上的矩形楔形物。 在另一个实施例中，光源作为激光器操作以在传感器表面上激发荧光，并且通过以特定配置定位的适当的光学元件将荧光选择性地导向检测器。

公开(公告)号：US20130128266A1

公开(公告)日：2013-05-23

申请号：US13741824

申请日：2013-01-15

Applicant: Spectro, Inc.

Inventor： Scott Albin ,  Thomas Barraclough ,  Michael Morkos ,  Patrick Henning ,  Eric John Olson ,  Kevin Keough

IPC: G01J3/28 ,  G01N21/01

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/10 ,  G01N21/01 ,  G01N21/03 ,  G01N21/274 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/3577 ,  G01N2021/0346

Abstract: A spectrometer sample head including a housing, at least one source of radiation in the housing, and a flip top sample cell including first and second hinged plates and a window through the first plate with a pane in the window, the pane for receiving a sample thereon. The housing includes a channel for receiving the plates when coupled together for placing the sample in the optical path of the radiation.

Abstract translation: 一种光谱仪样品头，包括壳体，壳体中的至少一种辐射源，以及包括第一和第二铰接板的翻盖样品池和通过第一板的窗口，窗口中的窗玻璃，用于接收样品 上。 壳体包括用于在连接在一起以将样品放置在辐射的光路中时接收板的通道。

公开(公告)号：US20130107260A1

公开(公告)日：2013-05-02

申请号：US13646935

申请日：2012-10-08

Applicant: SEIKO EPSON CORPORATION

Inventor： Takeshi NOZAWA

IPC: G01J3/42

CPC classification number: G01J3/42 ,  G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/26 ,  G01J3/32 ,  G02B26/001

Abstract: A spectrometer includes a light source section that includes a plurality of LEDs having different emission wavelengths, a variable wavelength interference filter that selectively extracts light of a predetermined wavelength, a detector that detects the amount of light, and a control circuit section. The control circuit section includes a mode switching section that switches a calibration mode and a measurement mode, an outside light analysis section that analyzes characteristics of outside light in the calibration mode, a reference light setting section that set the amount of light emitted from each of the LEDs on the basis of the characteristics of the outside light, and a light source driving section that drives each of the LEDs on the basis of the amount of light emitted which is set in the measurement mode.

Abstract translation: 光谱仪包括光源部分，其包括具有不同发射波长的多个LED，选择性地提取预定波长的光的可变波长干涉滤光器，检测光量的检测器和控制电路部分。 控制电路部分包括切换校正模式和测量模式的模式切换部分，分析校准模式中的外部光的特性的外部光分析部分，设置从每个模式发出的光量的参考光设定部分 基于外部光的特性的LED，以及基于在测量模式中设定的发光量来驱动每个LED的光源驱动部。

公开(公告)号：US08433384B2

公开(公告)日：2013-04-30

申请号：US12875925

申请日：2010-09-03

Applicant: Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

Inventor： Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

IPC: A61B5/00

CPC classification number: A61B5/0059 ,  A61B5/0091 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The present invention pertains to a method and apparatus for cerebral oximetry. A modulated optical signal based on a digital code sequence is transmitted to the human brain. A temporal transfer characteristic is derived from the modulated optical signal. Oxygen level in the brain is determined based on the temporal transfer characteristic.

Abstract translation: 本发明涉及脑血氧测定法的方法和装置。 基于数字码序列的调制光信号被传送到人脑。 从调制光信号导出时间传递特性。 基于时间转移特征确定脑中的氧水平。

公开(公告)号：US20130099120A1

公开(公告)日：2013-04-25

申请号：US13519282

申请日：2011-01-11

Applicant: Leo L. Chan ,  Peter Li

Inventor： Leo L. Chan ,  Peter Li

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01J3/10 ,  G01J3/4406 ,  G01J5/10 ,  G01N15/1463 ,  G01N21/3581 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N33/5005 ,  G01N2015/1486 ,  G01N2021/1736 ,  G01N2021/174 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6491 ,  G01N2201/0627

Abstract: The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention relates to systems and methods for imaging, measuring, counting, analyzing, and monitoring microscopic particles such as cells and biological molecules in solution samples.

Abstract translation: 本发明一般涉及用于分析和测量细胞和生物样品的分析和监测系统。 更具体地，本发明涉及用于在溶液样品中成像，测量，计数，分析和监测微观颗粒如细胞和生物分子的系统和方法。

公开(公告)号：US08416818B2

公开(公告)日：2013-04-09

申请号：US13160335

申请日：2011-06-14

Applicant: Brett Eugene Bouma ,  Seok-Hyun (Andy) Yun ,  Wang-Yuhl (William) Oh ,  Johannes F. De Boer ,  Guillermo J. Tearney

Inventor： Brett Eugene Bouma ,  Seok-Hyun (Andy) Yun ,  Wang-Yuhl (William) Oh ,  Johannes F. De Boer ,  Guillermo J. Tearney

IPC: H01S3/10

CPC classification number: G01J3/10 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02091 ,  G01J3/12 ,  G01J9/0215 ,  G01N21/4795 ,  G02B27/48 ,  H01S3/08009 ,  H01S3/08063 ,  H01S3/105 ,  H01S5/141 ,  H01S5/146 ,  H01S5/4087

Abstract: An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

公开(公告)号：US20130070246A1

公开(公告)日：2013-03-21

申请号：US13613463

申请日：2012-09-13

Applicant: Dar-Bin SHIEH ,  Pau-Choo CHUNG

Inventor： Dar-Bin SHIEH ,  Pau-Choo CHUNG

IPC: G01J3/00

CPC classification number: G01N21/255 ,  A61B5/0075 ,  A61B5/6898 ,  A61B2560/0431 ,  A61B2562/046 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/10 ,  G01J3/2803 ,  G01N21/251 ,  G01N21/474 ,  G01N21/49 ,  G01N2021/4742 ,  G01N2201/067 ,  G01N2201/0833

Abstract: An optical detection apparatus used for detecting a tissue includes a light-emitting unit, a spectroscopic unit and a light-sensing array. The light-emitting unit emits light entering into the tissue. The spectroscopic unit receives the light outputted from the tissue and divides the received light into a plurality of rays with different wavelengths. The light-sensing array senses the rays outputted from the spectroscopic unit so as to generate an array spectrum. By the spectroscopic unit, the detection of the rays of multiple wavelengths can be performed without using plural light-emitting diodes for emitting light of different wavelengths. Besides, the user can perceive the detection result (e.g. the location of the abnormal tissue) intuitively by integrating the light-sensing array and the spectroscopic unit.

Abstract translation: 用于检测组织的光学检测装置包括发光单元，分光单元和光感测阵列。 发光单元发射进入组织的光。 分光单元接收从组织输出的光，并将接收的光分成具有不同波长的多个光线。 感光阵列感测从分光单元输出的光线，以产生阵列光谱。 通过分光单元，可以不使用多个用于发射不同波长的光的发光二极管来执行多个波长的光线的检测。 此外，通过集成光感测阵列和分光单元，用户可以直观地感知检测结果（例如异常组织的位置）。

公开(公告)号：US08374682B2

公开(公告)日：2013-02-12

申请号：US11396941

申请日：2006-04-04

Applicant: Jenny E. Freeman ,  Svetlana V. Panasyuk ,  Michael J. Hopmeier ,  Kevin Schomacker ,  Derek Brand

Inventor： Jenny E. Freeman ,  Svetlana V. Panasyuk ,  Michael J. Hopmeier ,  Kevin Schomacker ,  Derek Brand

IPC: A61B6/00

CPC classification number: A61B5/743 ,  A61B5/0059 ,  A61B5/145 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/412 ,  A61B5/444 ,  A61B5/445 ,  A61B5/7275 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/10 ,  G01J3/12 ,  G01J3/2823 ,  G06F19/00 ,  G06T7/0012

Abstract: The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.

Abstract translation: 本发明涉及医学组织的高光谱和多光谱成像的方法和系统。 特别地，本发明涉及用于检测和评估诸如但不限于糖尿病和外周血管疾病的结合高光谱或多光谱成像的疾病和病症的新装置，工具和方法。

公开(公告)号：US20130033704A1

公开(公告)日：2013-02-07

申请号：US13285712

申请日：2011-10-31

Applicant: Guorong V. Zhuang ,  Shankar Krishnan ,  Johannes D. de Veer ,  Klaus Flock ,  David Y. Wang ,  Lawrence D. Rotter

Inventor： Guorong V. Zhuang ,  Shankar Krishnan ,  Johannes D. de Veer ,  Klaus Flock ,  David Y. Wang ,  Lawrence D. Rotter

IPC: G01C1/00

CPC classification number: G01J3/0264 ,  G01B2210/56 ,  G01J3/0208 ,  G01J3/0278 ,  G01J3/06 ,  G01J3/10 ,  G01N21/4785

Abstract: The present invention may include loading a diagnostic sample onto a sample stage, focusing light from an illumination source disposed on a multi-axis stage onto the diagnostic sample, collecting a portion of light reflected from a surface of the diagnostic sample utilizing a detector, wherein the illumination source and the detector are optically direct-coupled via an optical system, acquiring a set of diagnostic parameters indicative of illumination source position drift from the diagnostic sample, determining a magnitude of the illumination source position drift by comparing the acquired set of diagnostic parameters to an initial set of parameters obtained from the diagnostic sample at a previously measured alignment condition, determining a direction of the illumination source position drift; and providing illumination source position adjustment parameters configured to correct the determined magnitude and direction of the illumination source position drift to the multi-axis actuation control system of the multi-axis stage.

Abstract translation: 本发明可以包括将诊断样本加载到样本台上，将来自设置在多轴平台上的照明源的光聚焦到诊断样本上，利用检测器收集从诊断样品的表面反射的一部分光，其中 照明源和检测器通过光学系统光学直接耦合，获取指示来自诊断样本的照明源位置漂移的一组诊断参数，通过比较所获取的诊断参数集合来确定照明源位置漂移的大小 到在先前测量的对准条件下从诊断样本获得的初始参数集合，确定照明源位置漂移的方向; 以及提供照明源位置调整参数，其被配置为校正所确定的照明源位置漂移的大小和方向到所述多轴平台的多轴致动控制系统。

公开(公告)号：US20130027707A1

公开(公告)日：2013-01-31

申请号：US13548578

申请日：2012-07-13

Applicant: Tomonori MATSUSHITA ,  Yasushi MATSUNO

Inventor： Tomonori MATSUSHITA ,  Yasushi MATSUNO

IPC: G02B26/00 ,  G01N21/59

CPC classification number: G01J3/0291 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/10 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J3/51 ,  G02B5/284 ,  G02B26/001

Abstract: A filter includes a fixed substrate, a movable substrate opposed to the fixed substrate, a first reflection film provided on a surface of the fixed substrate facing the movable substrate, a second reflection film provided on the movable substrate and opposed to the first reflection film across a gap, a first electrode provided on the surface of the fixed substrate facing the movable substrate, a second electrode provided on the movable substrate and opposed to the first electrode, bonding parts provided on opposing surfaces of the fixed and movable substrates and bonding the fixed substrate to the movable substrate, and a groove part provided in at least one of the opposing surfaces, and the gap is in communication with an exterior of the filter via the groove part.

Abstract translation: 滤光器包括固定基板，与固定基板相对的可移动基板，设置在固定基板的面对可动基板的表面上的第一反射膜，设置在可移动基板上并与第一反射膜相对的第二反射膜 间隙，设置在固定基板的面对可动基板的表面上的第一电极，设置在可移动基板上并与第一电极相对的第二电极，设置在固定和可移动基板的相对表面上的接合部分， 衬底到可移动衬底，以及设置在至少一个相对表面中的槽部分，并且间隙经由槽部与过滤器的外部连通。