公开(公告)号：US5173749A

公开(公告)日：1992-12-22

申请号：US634126

申请日：1991-03-05

Applicant: Robert Tell ,  Torbjorn Andersson ,  Stefan Lundqvist ,  Henrik Ahlberg

Inventor： Robert Tell ,  Torbjorn Andersson ,  Stefan Lundqvist ,  Henrik Ahlberg

IPC: G01J3/42 ,  G01J1/44 ,  G01N21/03 ,  G01N21/27 ,  G01N21/35 ,  G01N21/39 ,  G01N21/59 ,  H01S5/024

CPC classification number: G01N21/39 ,  G01N21/031 ,  G01J2001/4242 ,  G01N2021/1751 ,  G01N21/3504 ,  G01N2201/0826

Abstract: Method and apparatus for spectroscopic measurement of the concentration of a gas in a sample where you detect the intensity of light from a light source (1) passed through the sample (4) and through a reference cell (5) and generates a signal which represents the concentration of the gas. A laser diode (1) constitutes the light source which is locked to the absorption line of the gas at known concentration and pressure contained in a reference cell (5). The laser light with the properly selected wavelength is distributed via optical fibres (2, 3, 6) and/or glass prisms (19, 20) to the reference cell (5) and the sample (4). Non-gas-related transmission variations in the measurement path or in the optics is automatically compensated for by a special laser modulation which generates a time multiplexed reference. The measurement can be performed in a measurement cell incorporating several reflective mirrors (30) to reflect the laser beam several times inside the measurement cell thereby increasing the effective length of the measurement path. The measurement can also be performed using an optical fiber designed so that the surrounding gas or fluid via the evanescent field affects the laser light so that the concentration of the substance in question in the surrrounding fluid or gas can be determined.

Abstract translation: PCT No.PCT / SE89 / 00404 Sec。 371日期1991年3月5日 102（e）1991年3月5日PCT PCT 1989年7月7日PCT公布。 公开号WO90 / 00732 1990年1月25日。用于光谱测量样品中气体浓度的方法和装置，其中检测来自通过样品（4）和通过参考细胞（5）的光源（1）的光强度 ）并产生表示气体浓度的信号。 激光二极管（1）构成在参考电池（5）中包含的已知浓度和压力下锁定到气体的吸收线的光源。 具有适当选择的波长的激光通过光纤（2,3,6）和/或玻璃棱镜（19,20）分配到参考电池（5）和样品（4）。 通过产生时间复用参考的特殊激光调制自动补偿测量路径或光学系统中的非气体相关传输变化。 可以在包含多个反射镜（30）的测量单元中进行测量，以在测量单元内反射多次激光束，从而增加测量路径的有效长度。 该测量也可以使用设计成使得周围的气体或通过渐逝场的流体影响激光的光纤进行测量，从而可以确定周边流体或气体中所讨论的物质的浓度。

公开(公告)号：US5048524A

公开(公告)日：1991-09-17

申请号：US318779

申请日：1989-03-03

Applicant: Wilber H. Bailey

Inventor： Wilber H. Bailey

IPC: A61B5/00

CPC classification number: G01N21/314 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/1459 ,  A61B2562/08 ,  G01N2201/0627 ,  G01N2201/0826

Abstract: A method and apparatus for measuring the oxygen saturation level and hematocrit of human blood in real time. A catheter having a notch in its tip is inserted into a blood vessel and guided to a desired location in the body of a patient. Bursts of light at each of three wavelengths are transmitted through the blood in the notch. The intensities of the bursts of light after transmission are utilized along with a set of molecular exinction coefficients and optical scattering coefficients to calculate the oxygen level and hermatocrit. The light is provided by a set of LEDs in a housing connected to the catheter and the intensity of the transmitted light is measured by a photocell in the same housing. Optical fibers transmit the light through the catheter between the housing and the notch. Characterization resistors in the housing are encoded with characteristics such as the wavelengths of the LEDs and the width of the notch. In an alternate embodiment blood circulating through a loop out of the patient's body is passed through a chamber and is exposed to the light.

Abstract translation: 一种用于实时测量人血液氧饱和度和血细胞比容的方法和装置。 将其顶端具有切口的导管插入血管并引导到患者体内的所需位置。 三个波长中的每一个的突发通过缺口中的血液传输。 传播后的光脉冲的强度与一组分子排除系数和光散射系数一起被用于计算氧水平和阴道分度。 光由连接到导管的壳体中的一组LED提供，并且透射光的强度由相同壳体中的光电池测量。 光纤通过导管将光透过壳体和凹口之间。 壳体中的表征电阻器被编码为诸如LED的波长和凹口的宽度的特性。 在替代实施例中，通过环路从患者身体循环的血液通过腔室并暴露于光。

公开(公告)号：US4969741A

公开(公告)日：1990-11-13

申请号：US383798

申请日：1989-07-21

Applicant: Max J. Kennedy ,  Daniel I. C. Wang ,  Gregory N. Stephanopoulos

Inventor： Max J. Kennedy ,  Daniel I. C. Wang ,  Gregory N. Stephanopoulos

IPC: G01N21/51 ,  G01N21/85

CPC classification number: G01N21/51 ,  G01N21/8507 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: This invention pertains to a method and an apparatus for determining concentration of solid particles of interest in a sample in the presence of at least one other type of solid particle by measuring light scatter at a wavelength which is independent of solid particle concentration which is not of interest and related to solid particle concentration of interest. Preferably, solid particles of interest are cells grown in cell culture medium comprising a solid substrate.

Abstract translation: 本发明涉及一种用于在存在至少一种其它类型的固体颗粒的情况下测定样品中感兴趣的固体颗粒的浓度的方法和装置，其通过测量与不是固体颗粒浓度的固体颗粒浓度无关的波长的光散射 感兴趣并与感兴趣的固体颗粒浓度有关。 优选地，感兴趣的固体颗粒是在包含固体底物的细胞培养基中生长的细胞。

公开(公告)号：US4940333A

公开(公告)日：1990-07-10

申请号：US271034

申请日：1988-11-14

Applicant: Janusz B. Pawliszyn

Inventor： Janusz B. Pawliszyn

IPC: G01N21/25 ,  G01N21/45 ,  G01N27/26 ,  G01N30/74 ,  G01N35/08

CPC classification number: G01N21/455 ,  G01N30/74 ,  G01N2201/0621 ,  G01N2201/0696 ,  G01N2201/0826 ,  G01N35/085

Abstract: Concentration gradients in samples to be evaluated are detected by measuring the deflection of a probe light beam passed through the sample using the principals of Schlieren optics. Specific chemical compounds in a sample can be detected and identified by supplying excitation energy to the sample where such energy is selected to be absorbed by the chemical compound to be specifically identified and not by other compounds in the sample. The absorption of the excitation energy by the absorbing compound produces a temperature gradient within the sample which causes deflection of the probe light beam and signals representative of such deflection may be separated from signals representative of deflections caused by other refractive index gradient present in the sample. A light emitting diode may be used to generate the probe light beam. Rather than detecting movement of the probe light beam caused by an unknown gradient, by passing the probe light beam through a known gradient, with or without excitation energy present, the light beam can be deflected in a controlled manner.

Abstract translation: 通过使用Schlieren光学原理测量通过样品的探针光束的偏转来检测要评估的样品中的浓度梯度。 可以通过向样品中提供激发能量来检测和鉴定样品中的特定化合物，其中这种能量被选择为待被特定鉴定的化合物吸收，而不是样品中的其他化合物吸收。 吸收化合物对激发能的吸收在样品内产生温度梯度，引起探针光束的偏转，代表这种偏转的信号可以与代表样品中存在的其它折射率梯度引起的偏转的信号分离。 可以使用发光二极管来产生探测光束。 通过使探测光束通过具有或不具有激发能量的已知梯度而不是检测由未知梯度引起的探测光束的移动，可以以受控的方式偏转光束。

公开(公告)号：US4738535A

公开(公告)日：1988-04-19

申请号：US888122

申请日：1986-07-22

Applicant: Donald R. Webster

Inventor： Donald R. Webster

IPC: G01N21/27 ,  F21V8/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/12 ,  G01N21/31 ,  G01J3/51

CPC classification number: G01N21/314 ,  G02B6/0006 ,  G01J2003/1243 ,  G01J3/0221 ,  G01J3/10 ,  G01N2201/0826

Abstract: In an optical instrument, fiber optics are employed to receive light from a linear filament. The fiber optics are arranged into a plurality of light receiving bundle ends distributed around the linear filament and shaped into narrow rectangular slits aligned with the filament. The fibers from each of the receiving ends are equally distributed between two transmitting ends which direct the light through cylindrical lenses to opposite sides of a rotating filter wheel in a paddle wheel configuration. Light beams from the transmitting ends of the fiber optic bundles pass through filters on the filter wheel to additional fiber optic bundles which carry the received light to a probe.

Abstract translation: 在光学仪器中，使用光纤来接收来自线状灯丝的光。 纤维光学器件被布置成分布在线状细丝周围的多个光接收束端，并成形成与灯丝对准的窄矩形狭缝。 来自每个接收端的光纤被均匀分布在两个发射端之间，两个发射端之间通过圆柱透镜将光引导到桨轮结构中的旋转滤光轮的相对侧。 来自光纤束的发射端的光束通过滤光轮上的滤光器，将附着的光纤束传送到探头上。

公开(公告)号：US3453440A

公开(公告)日：1969-07-01

申请号：US51370265

申请日：1965-12-14

Applicant: MOLINS ORGANISATION LTD

Inventor： MUIR DOUGLAS WILLIAM BALLANTYN ,  HIDER PHILIP FRANK

IPC: A24C5/34 ,  F21V8/00 ,  G01N21/952 ,  G02B6/04 ,  G02B6/42 ,  H01J5/16 ,  G02B5/16 ,  H01J39/12

CPC classification number: G01N21/952 ,  A24C5/3412 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/0006 ,  G02B6/4298 ,  Y10S131/908

公开(公告)号：US11920976B2

公开(公告)日：2024-03-05

申请号：US17753302

申请日：2020-08-27

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： John P. Mizzer ,  Donald Wood

IPC: G01J1/02 ,  G01N35/00

CPC classification number: G01J1/0271 ,  G01N2035/00356 ,  G01N2201/0826

Abstract: A system for coupling photometers to an incubation ring for use in in vitro diagnostics comprises one or more light sources, and an incubation ring assembly, and two photometers. An incubation ring assembly comprises an internal trough and an external trough. Each trough comprises (a) an internal wall comprising an internal aperture and (b) an external wall comprising an external aperture. A first photometer comprises: a first optics housing directing light from the light sources through the external aperture of the internal trough, and a first detector positioned to receive the light through the internal aperture of the internal trough. A second photometer comprises a second optics housing directing the light from the light sources through the internal aperture of the external trough, and a second detector positioned to receive the light through the external aperture of the external trough.

公开(公告)号：US11800981B2

公开(公告)日：2023-10-31

申请号：US16949466

申请日：2020-10-30

Applicant: Colgate-Palmolive Company

Inventor： Deborah Ann Peru ,  Hrebesh Molly Subhash

IPC: A61B5/00 ,  G01J3/02 ,  G02B6/04 ,  G01J3/06 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/08 ,  G01J3/10 ,  G01N21/25 ,  G01J3/18 ,  G01J3/36 ,  G01N21/31 ,  G01J3/32

CPC classification number: A61B5/0075 ,  A61B5/0062 ,  A61B5/0088 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/4875 ,  G01J3/021 ,  G01J3/024 ,  G01J3/0205 ,  G01J3/027 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/0229 ,  G01J3/0264 ,  G01J3/0291 ,  G01J3/06 ,  G01J3/08 ,  G01J3/10 ,  G01J3/18 ,  G01J3/32 ,  G01J3/36 ,  G01N21/255 ,  G01N21/31 ,  G02B6/04 ,  A61B5/441 ,  A61B5/4872 ,  A61B2562/0233 ,  G01J2003/061 ,  G01J2003/065 ,  G01J2003/066 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/0846

Abstract: A spectroscopic system may include: a probe having a probe tip and an optical coupler, the optical coupler including an emitting fiber group and first and second receiving fiber groups, each fiber group having a first end and a second end, wherein the first ends of the fiber groups are formed into a bundle and optically exposed through the probe tip; a light source optically coupled to the second end of the emitting fiber group, the light source emitting light in at least a first waveband and a second waveband, the second waveband being different from the first waveband; a first spectrometer optically coupled to the second end of the first receiving fiber group and configured to process light in the first waveband; and a second spectrometer optically coupled to the second end of the second receiving fiber group and configured to process light in the second waveband.

公开(公告)号：US20230221246A1

公开(公告)日：2023-07-13

申请号：US18009294

申请日：2022-01-14

Applicant: WOODS HOLE OCEANOGRAPHIC INSTITUTION

Inventor： Jason KAPIT ,  Anna MICHEL

IPC: G01N21/3504 ,  G01N21/359

CPC classification number: G01N21/3504 ,  G01N21/359 ,  G01N2201/0826 ,  G01N2201/0636 ,  G01N2201/0634 ,  A61B2010/0083

Abstract: An apparatus and method of use are provided; the apparatus having at least a degasser, a hollow core fiber HCF, an optical mechanism, a detector, and circuitry. The degasser enables gasses to permeate out of a liquid into the degasser interior. The propagator establishes a low-pressure area that helps to pull the gas from the degasser interior into the HCF interior, where the optical mechanism delivers electromagnetic radiation EMR that interacts with the gas. The detector determines EMR absorption, producing output signals which are sent to the circuitry. Circuitry controls the optical mechanism and analyzes the output signals to quantify the concentration of gas in the HCF and in the liquid.

公开(公告)号：US20230194425A1

公开(公告)日：2023-06-22

申请号：US18173056

申请日：2023-02-22

Applicant: ACCESS MEDICAL SYSTEMS, LTD.

Inventor： Hong Tan

IPC: G01N21/45 ,  G01J3/02 ,  G01J3/45 ,  G01N21/77 ,  G01N21/85

CPC classification number: G01N21/45 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/024 ,  G01J3/45 ,  G01N21/7703 ,  G01N21/8507 ,  G01N2021/458 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2021/772 ,  G01N21/55

Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly includes a light source to emit light signals; a light detector to detect light signals; a coupler to optically couple the light source and the light detector to a waveguide tip; a monolithic substrate having a coupling side and a sensing side; and a lens between the waveguide tip and the monolithic substrate. The lens relays optical signals between the waveguide tip and the monolithic substrate.