公开(公告)号：US20100213854A1

公开(公告)日：2010-08-26

申请号：US12775098

申请日：2010-05-06

Applicant: Jack C. RAINS, JR. ,  Don F. May ,  David P. Ramer

Inventor： Jack C. RAINS, JR. ,  Don F. May ,  David P. Ramer

IPC: H05B37/02

CPC classification number: F21V7/0008 ,  F21K9/62 ,  F21K9/68 ,  F21S2/00 ,  F21S10/02 ,  F21V5/002 ,  F21V5/008 ,  F21V7/22 ,  F21V11/10 ,  F21V14/06 ,  F21V23/0442 ,  F21V23/0457 ,  F21V2200/13 ,  F21W2131/406 ,  F21Y2113/00 ,  F21Y2113/13 ,  F21Y2113/20 ,  F21Y2115/10 ,  G01J1/08 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0254 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0286 ,  G01J3/10 ,  G01J3/50 ,  G01J3/501 ,  G02B5/0252 ,  G02B5/0278 ,  G02B5/0284 ,  G02B6/0008 ,  G03B15/06 ,  G09F13/0404 ,  G09F13/06 ,  G09F13/14 ,  G09F13/22 ,  H05B33/0803 ,  H05B33/0812 ,  H05B33/0842 ,  H05B33/0863 ,  H05B33/0869 ,  H05B33/0872 ,  H05B35/00 ,  Y02B20/343

Abstract: A light fixture, using one or more solid state light emitting elements utilizes a diffusely reflect chamber to provide a virtual source of uniform output light, at an aperture or at a downstream optical processing element of the system. Systems disclosed herein also include a detector, which detects electromagnetic energy from the area intended to be illuminated by the system, of a wavelength absent from a spectrum of the combined light system output. A system controller is responsive to the signal from the detector. The controller typically may control one or more aspects of operation of the solid state light emitter(s), such as system ON-OFF state or system output intensity or color. Examples are also discussed that use the detection signal for other purposes, e.g. to capture data that may be carried on electromagnetic energy of the wavelength sensed by the detector.

Abstract translation: 使用一个或多个固态发光元件的灯具利用漫反射室来在系统的孔径或下游光学处理元件处提供均匀输出光的虚拟源。 本文公开的系统还包括检测器，其从组合光系统输出的频谱中不存在的波长检测来自系统要被照明的区域的电磁能。 系统控制器响应来自检测器的信号。 控制器通常可以控制固态光发射器的操作的一个或多个方面，诸如系统开 - 关状态或系统输出强度或颜色。 还讨论了将其用于其它目的的检测信号的实例。 以捕获可以由检测器感测的波长的电磁能量承载的数据。

公开(公告)号：US07742166B2

公开(公告)日：2010-06-22

申请号：US11740767

申请日：2007-04-26

Applicant: Jan Lipson ,  Albert L. Lipson ,  Robert P. McNamara

Inventor： Jan Lipson ,  Albert L. Lipson ,  Robert P. McNamara

IPC: G01J3/00

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0289 ,  G01N21/4738 ,  G01N2021/4709 ,  G01N2021/4747 ,  G01N2021/656 ,  G01N2201/124

Abstract: An apparatus for enhancing the selectivity for spectroscopic measurements of analytes in a turbid medium is described. In one example, spatial filters are used to select only certain radii from the medium to be imaged. This selection is accomplished by placing an optical obstruction on the surface of the medium or at an image plane of the surface later in the optical imaging system. In one implementation, this is achieved by placing a fiber bundle at an image plane of the collecting optical system and then using a spacer of appropriate size at the center of the fiber bundle to act as a central obstruction.

Abstract translation: 描述了用于提高浑浊介质中分析物的光谱测量的选择性的装置。 在一个示例中，空间滤波器用于仅从要成像的介质中选择某些半径。 该选择通过在光学成像系统中稍后将光学障碍物放置在介质的表面或表面的像平面上来实现。 在一个实施方案中，这是通过将纤维束放置在收集光学系统的像平面上，然后在纤维束的中心使用适当尺寸的间隔件来充当中心障碍物来实现的。

公开(公告)号：US07738097B2

公开(公告)日：2010-06-15

申请号：US12174313

申请日：2008-07-16

Applicant: Altaf Khetani ,  Majid Naji ,  Neil Lagali ,  Hanan Anis ,  Rejean Munger

Inventor： Altaf Khetani ,  Majid Naji ,  Neil Lagali ,  Hanan Anis ,  Rejean Munger

IPC: G01J3/44 ,  G01N21/65 ,  G02B6/32

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01N21/0303 ,  G01N21/65 ,  G01N21/658 ,  G01N21/7703

Abstract: A method is provided for biosensing using a photonic crystal fiber having a hollow core. The method includes: designating an analyte of interest; determining a wavelength for an excitation light source which generates a Raman spectrum when incident upon the analyte of interest; selecting a photonic crystal fiber that would guide the light when the fiber is non-selectively filled with a solvent hosting the analyte of interest; non-selectively filling a photonic crystal fiber with the solvent hosting the analyte of interest; interrogating the analyte of interest by coupling light from the light source to the photonic crystal fiber; and analyzing the light output from the photonic crystal fiber for Raman fingerprints.

Abstract translation: 提供一种使用具有中空芯的光子晶体纤维进行生物传感的方法。 该方法包括：指定感兴趣的分析物; 确定激发光源的波长，其在入射到感兴趣的分析物时产生拉曼光谱; 选择光纤晶体光纤，当光纤被非选择性地填充托管目标分析物的溶剂时，该光子晶体光纤将引导光; 用选择感兴趣的分析物的溶剂非选择性填充光子晶体纤维; 通过将来自光源的光耦合到光子晶体光纤来询问感兴趣的分析物; 并分析拉曼指纹光子晶体光纤的光输出。

公开(公告)号：US07724378B2

公开(公告)日：2010-05-25

申请号：US12379343

申请日：2009-02-19

Applicant: Noam Babayoff

Inventor： Noam Babayoff

IPC: G01B11/24

CPC classification number: H04N13/15 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/0615 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/24 ,  A61B1/247 ,  A61B5/0068 ,  A61B5/0088 ,  A61B5/1077 ,  A61B5/1079 ,  A61C9/0053 ,  A61C9/0066 ,  A61C19/04 ,  G01B11/24 ,  G01B11/25 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0243 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/462 ,  G01J3/50 ,  G01J3/501 ,  G01J3/508 ,  G01J3/51 ,  G01N21/255 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10028 ,  G06T2207/30036 ,  H01L27/14868 ,  H04N13/207 ,  H04N13/257 ,  H04N13/271 ,  H04N13/296

Abstract: A device for determining the surface topology and associated color of a structure, such as a teeth segment, includes a scanner for providing depth data for points along a two-dimensional array substantially orthogonal to the depth direction, and an image acquisition means for providing color data for each of the points of the array, while the spatial disposition of the device with respect to the structure is maintained substantially unchanged. A processor combines the color data and depth data for each point in the array, thereby providing a three-dimensional color virtual model of the surface of the structure. A corresponding method for determining the surface topology and associated color of a structure is also provided.

Abstract translation: 用于确定诸如齿段的结构的表面拓扑和相关联颜色的装置包括用于为基本上与深度方向正交的二维阵列的点提供深度数据的扫描器，以及用于提供颜色的图像获取装置 数据，而阵列相对于结构的空间布置基本上保持不变。 处理器组合阵列中每个点的颜色数据和深度数据，从而提供结构表面的三维颜色虚拟模型。 还提供了用于确定结构的表面拓扑和相关联颜色的相应方法。

公开(公告)号：US07718440B2

公开(公告)日：2010-05-18

申请号：US11749073

申请日：2007-05-15

Applicant: Homer Paul Pien ,  William C. Karl ,  Derek Puff ,  Peter Li ,  Brian Cunningham

Inventor： Homer Paul Pien ,  William C. Karl ,  Derek Puff ,  Peter Li ,  Brian Cunningham

IPC: G01N21/72

CPC classification number: G01N21/7743 ,  B01L3/5085 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/1804 ,  G01J3/42 ,  G01N21/253 ,  G01N21/31 ,  G01N33/54373 ,  G01N2021/3196 ,  G01N2021/7773 ,  G02B5/1809 ,  Y10S436/805

Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.

Abstract translation: 对生物传感器的光谱特性进行相对偏移的高分辨率测定。 生物传感器的共振峰的偏移指示与生物传感器的表面结合的材料的量。 优选的生物传感器是引导模式谐振滤波器生物传感器（GMRFB）。 在本发明的一个方面，使用曲线拟合来确定未暴露的生物传感器的光谱相对于通过存在与生物传感器的表面结合的材料而被改变（例如，偏移）的那些光谱的相对位置。 在替代实施例中，互相关函数用于检测参考光谱和从暴露的生物传感器测量的光谱之间的光谱峰值偏移。 在另一替代方案中，使用最大似然估计技术来确定频谱偏移或偏移。

公开(公告)号：US20100085564A1

公开(公告)日：2010-04-08

申请号：US12403522

申请日：2009-03-13

Applicant: Xun Guo ,  Hong Wang ,  Chunwei Liu

Inventor： Xun Guo ,  Hong Wang ,  Chunwei Liu

IPC: G01J3/44

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/44 ,  G01N21/15 ,  G01N21/658 ,  G01N21/94 ,  G01N2021/656

Abstract: A method for detecting an ingredient in a food product or detecting a disease includes allowing a food sample solution obtained from a food product or a body fluid from an individual to come to contact with a nano-scale surface structure in a sensor, wherein the nano-scale surface structure comprises a plurality of columns over a substrate or a plurality of holes in a substrate. The method includes illuminating the food sample solution or the body fluid on the nano-scale surface structure on the sensor by a laser beam; obtaining a Raman spectrum from the scattered light using a spectral analyzer; and identifying the spectral signature in the Raman spectrum to determine the existence of the chemical substance in the food product or identifying a disease in the individual.

Abstract translation: 用于检测食品中的成分或检测疾病的方法包括使得从个体的食品或体液获得的食品样品溶液与传感器中的纳米级表面结构接触，其中所述纳米 尺寸表面结构包括在衬底上的多个柱或衬底中的多个孔。 该方法包括通过激光束照射传感器上的纳米级表面结构上的食物样品溶液或体液; 使用光谱分析仪从散射光获得拉曼光谱; 并确定拉曼光谱中的光谱特征，以确定食品中化学物质的存在或识别个体中的疾病。

公开(公告)号：US20100010325A1

公开(公告)日：2010-01-14

申请号：US12562050

申请日：2009-09-17

Applicant: Trent Ridder ,  Ben ver Steeg ,  James McNally ,  John Maynard ,  Russell Abbink ,  Mike Mills ,  Bentley Laaksonen

Inventor： Trent Ridder ,  Ben ver Steeg ,  James McNally ,  John Maynard ,  Russell Abbink ,  Mike Mills ,  Bentley Laaksonen

IPC: A61B5/1455 ,  A61B5/117 ,  G06F7/04

CPC classification number: A61B5/4845 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/117 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6826 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/14 ,  G01J2003/1286 ,  G01N21/274 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: An apparatus and method for noninvasive determination of analyte properties of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems can include an illumination/modulation subsystem, a tissue sampling subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. The invention can provide analyte property determination and identity determination or verification from the same spectroscopic information, making unauthorized use or misleading results less likely than in systems that use separate analyte and identity determinations. The invention can be used to control and monitor individuals accessing controlled environments.

Abstract translation: 一种用于通过定量红外光谱法非临床确定人体组织的分析物质的临床相关水平的精确度和准确度的装置和方法。 该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。 子系统可以包括照明/调制子系统，组织采样子系统，数据采集子系统，计算子系统和校准子系统。 本发明可以提供来自相同光谱信息的分析物质性质确定和鉴别确定或验证，使得未经授权的使用或误导结果比使用单独的分析物和身份确定的系统更不可能。 本发明可用于控制和监视访问受控环境的个人。

公开(公告)号：US20090303475A1

公开(公告)日：2009-12-10

申请号：US12157142

申请日：2008-06-06

Applicant: Vijaysekhar Jayaraman ,  Timothy Andrew Strand ,  Devin Blaine Leonard

Inventor： Vijaysekhar Jayaraman ,  Timothy Andrew Strand ,  Devin Blaine Leonard

IPC: G02B6/02 ,  G01J3/42 ,  H01L21/58

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0259 ,  G02B6/1221 ,  G02B6/4203

Abstract: The invention discloses a multi-wavelength semiconductor light source comprising a plurality of semiconductor light sources mounted on a silicon sub-carrier and emitting radiation spanning a wavelength range. In preferred embodiments, these sources are configured in a linear and circular array. The radiation is coupled to a waveguide array disposed on the same silicon subcarrier, with a lower cladding of silicon dioxide and deposited core layer which is preferably the spin-on epoxy resin SU-8. Output from the waveguide array provides a compact multi-wavelength laser source with wide tuning range via a plurality of laser sources. An output spatial span of the waveguide array is smaller than an input spatial span and sufficiently small to probe the properties of a sample. A compact system for optical spectroscopy is constructed from the multi-wavelength semiconductor light source, a means for directing radiation from the source to a sample, and an optical detector configured to detect one of a radiation reflected from and transmitted through said sample. In various preferred embodiments, the semiconductor light sources can comprise lasers, light-emitting diodes, and superluminescent diodes.The system for optical spectroscopy can be used in a variety of applications including the analysis of in-vivo human tissue, agricultural samples, and pharmaceutical samples. Typical wavelength ranges for these and other applications include 650-1000 nm, 700-1700 nm, and 1100-2500 nm.

Abstract translation: 本发明公开了一种多波长半导体光源，其包括安装在硅副载体上并发射跨越波长范围的辐射的多个半导体光源。 在优选实施例中，这些源被配置成线性和圆形阵列。 辐射耦合到设置在相同的硅子载波上的波导阵列，其中二氧化硅的下包层和沉积的芯层，其优选是旋涂环氧树脂SU-8。 来自波导阵列的输出通过多个激光源提供具有宽调谐范围的紧凑的多波长激光源。 波导阵列的输出空间跨度小于输入空间跨度，足够小以探测样品的性质。 用于光学光谱的紧凑系统由多波长半导体光源构成，用于将来自源的辐射引导到样本的装置，以及被配置为检测从所述样品反射并透过所述样品的辐射中的一种的光学检测器。 在各种优选实施例中，半导体光源可以包括激光器，发光二极管和超发光二极管。 光谱学系统可用于各种应用，包括体内人体组织，农业样品和药物样品的分析。 这些和其他应用的典型波长范围包括650-1000nm，700-1700nm和1100-2500nm。

公开(公告)号：US20090297142A1

公开(公告)日：2009-12-03

申请号：US12127507

申请日：2008-05-27

Applicant: Bogdan Szafraniec ,  Douglas M. Baney

Inventor： Bogdan Szafraniec ,  Douglas M. Baney

IPC: H04B17/00

CPC classification number: G01J3/433 ,  G01J3/02 ,  G01J3/0218 ,  G01J2003/1265

Abstract: An optical spectrum analyzer and a method of spectrally analyzing an optical signal. The optical spectrum analyzer includes a wave shaper such as an optical modulator that shapes an optical signal, a dispersive element such as a dispersive fiber in which the shaped optical signal is dispersed, a detector that provides an output signal indicative of the dispersed shaped optical signal, and a signal processor that analyzes the output signal, for example by calculating a transform such as an inverse Fourier transform or a Fourier transform of the output signal, to provide a frequency spectrum of the optical signal.

Abstract translation: 光谱分析仪和光信号的光谱分析方法。 光谱分析仪包括诸如光调制器的波整形器，其形成光信号，分散元件如分散光纤，其中分布有成形光信号的检测器，提供表示分散的成形光信号的输出信号 以及分析输出信号的信号处理器，例如通过计算诸如反相傅立叶变换或输出信号的傅里叶变换的变换来提供光信号的频谱。

公开(公告)号：US07615761B2

公开(公告)日：2009-11-10

申请号：US12199984

申请日：2008-08-28

Applicant: Lukas Hunziker ,  Georg Herink ,  Arnaud Lepert

Inventor： Lukas Hunziker ,  Georg Herink ,  Arnaud Lepert

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/646 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0634

Abstract: A method for detecting trace evidence materials on a surface comprises irradiating the surface with radiation from two or more lasers emitting radiation at different wavelengths selected to stimulate luminescence in the trace materials. The evidence is detected by observing the surface through an optical filter arranged to transmit the luminescence, while blocking transmission of the laser radiation wavelengths reflected or scattered from the surface.

Abstract translation: 用于检测表面上的痕量证据材料的方法包括用来自两个或更多个激光器的辐射照射表面，所述激光器发射不同波长的辐射，以激发微量材料中的发光。 通过用布置成透射发光的滤光片观察表面，同时阻挡从表面反射或散射的激光辐射波长的透射来检测证据。