公开(公告)号：US07298483B2

公开(公告)日：2007-11-20

申请号：US10505186

申请日：2003-02-21

Applicant: Wayne D. Jung ,  Russell W. Jung ,  Walter W. Sloan ,  Alan R. Loudermilk

Inventor： Wayne D. Jung ,  Russell W. Jung ,  Walter W. Sloan ,  Alan R. Loudermilk

IPC: G01J3/46

CPC classification number: G01N21/25 ,  A61C19/04 ,  G01J1/0271 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0278 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/36 ,  G01J3/46 ,  G01J3/462 ,  G01J3/463 ,  G01J3/508 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01J2003/466 ,  G01N21/57

Abstract: A miniaturized spectrometer/spectrophotometer system and methods are disclosed. A probe tip including one or more light sources and a plurality of light receivers is provided. A first spectrometer system receives light from a first set of the plurality of light receivers. A second spectrometer system receives light from a second set of the plurality of light receivers. A processor, wherein the processor receives data generated by the first spectrometer system and the second spectrometer system, wherein an optical measurement of a sample under test is produced based on the data generated by the first and second spectrometer systems.

公开(公告)号：US20070263956A1

公开(公告)日：2007-11-15

申请号：US11782483

申请日：2007-07-24

Applicant: Andrew Sappey ,  James Howell ,  Henrik Hofvander ,  Bernard Masterson

Inventor： Andrew Sappey ,  James Howell ,  Henrik Hofvander ,  Bernard Masterson

IPC: G02B6/00

CPC classification number: G01J3/36 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0289 ,  G01J3/0297 ,  G01J3/108 ,  G01J3/1809 ,  G01J5/601 ,  G01J2003/104 ,  G01J2003/423 ,  G01N21/359 ,  G01N21/39 ,  G01N2021/399 ,  G02B6/14

Abstract: A catch side optical system for use in diode laser spectroscopy consisting of a catch side optic optically coupled to a catch side multimode optical fiber and means to mechanically manipulate a section of the catch side multimode optical fiber to minimize catch side mode noise. The mechanical manipulation may consist of twisting the catch side multimode optical fiber around its longitudinal axis. The means to mechanically manipulate the section of the catch side multimode optical fiber in the above fashion may consist of a motor associated with the catch side multimode optical fiber such that a section of fiber is held fast relative to a shaft position of the motor and the motor shaft is repetitively swept through +360 degrees and −360 degrees of motion. The frequency of the motor shaft sweep may be at least 10 Hz to enable effective averaging of the transmitted signal and thereby reduce the effect of catch side mode noise.

Abstract translation: 用于二极管激光光谱的捕获侧光学系统，其由光学耦合到捕获侧多模光纤的捕获侧光学和用于机械地操纵捕获侧多模光纤的一部分以最小化捕获侧模式噪声的装置组成。 机械操纵可以包括围绕其纵向轴线扭转捕获侧多模光纤。 以上述方式机械地操纵扣合侧多模光纤的部分的装置可以由与捕获侧多模光纤相关联的马达组成，使得光纤的一部分相对于马达的轴位置保持快速，并且 电机轴重复扫过+ 360度和-360度的运动。 电机轴扫描的频率可以至少为10 Hz，以实现发射信号的有效平均，从而减少捕获侧模式噪声的影响。

公开(公告)号：US07280204B2

公开(公告)日：2007-10-09

申请号：US11101717

申请日：2005-04-08

Applicant: Joseph Paul Robinson ,  Bartlomiej Rajwa ,  Gérald Grégori ,  Valery Patsekin

Inventor： Joseph Paul Robinson ,  Bartlomiej Rajwa ,  Gérald Grégori ,  Valery Patsekin

IPC: G01J3/30

CPC classification number: G01J3/2803 ,  G01J3/36 ,  G01N15/1459 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/6439 ,  G01N2021/6482

Abstract: A multi-spectral detection and analysis system detects and classifies a targeted sample. The system may include a light source that causes the targeted sample to luminesce. A light dispersion element disperses the luminescence to a photodetector in a photodetector array. Each photodetector in the array transmits a signal indicating a portion of the spectrum to a multi-channel collection system. The multi-channel collection system processes the signal into a digital signal and forms the digital signal into a spectral signature. A processor analyzes the spectral signature and compares the spectral signature to known spectral signatures to identify the targeted sample.

Abstract translation: 多光谱检测和分析系统检测并分类目标样品。 该系统可以包括导致​​目标样品发光的光源。 光散射元件将发光分散到光电检测器阵列中的光电检测器。 阵列中的每个光电检测器将指示光谱的一部分的信号发送到多通道收集系统。 多通道采集系统将信号处理成数字信号，并将数字信号形成光谱特征。 处理器分析光谱签名并将光谱特征与已知光谱特征进行比较以识别目标样本。

公开(公告)号：US07267546B2

公开(公告)日：2007-09-11

申请号：US10914479

申请日：2004-08-09

Applicant: Robert R. Scott ,  Bruce S. McLean

Inventor： Robert R. Scott ,  Bruce S. McLean

IPC: G61C3/00 ,  G01J1/42

CPC classification number: G01J3/36 ,  A61C19/004 ,  G01J1/0271 ,  G01J1/4228 ,  G01J3/427 ,  G01J2001/4252

Abstract: A light meter for detecting two or more different wavelengths of light and methods for determining whether a light source configured to emit light at two or more dominant wavelengths is working properly. The inventive light meter includes a housing, two or more receiving means for receiving light energy emitted by an external light source wherein each receiving means is configured to receive light energy of a desired wavelength, detecting means for detecting and measuring light energy received by the receiving means, and display means for providing a visual indication of the existence and intensity of one or more wavelengths of light energy received by the receiving means.

Abstract translation: 用于检测两个或更多个不同波长的光的光度计和用于确定被配置为发射两个或更多个主波长的光的光源是否正常工作的方法。 本发明的光度计包括壳体，两个或更多个接收装置，用于接收由外部光源发射的光能，其中每个接收装置被配置为接收所需波长的光能;检测装置，用于检测和测量接收到的光能量 装置和显示装置，用于提供由接收装置接收的一个或多个波长的光能的存在和强度的视觉指示。

公开(公告)号：US20070188754A1

公开(公告)日：2007-08-16

申请号：US11672774

申请日：2007-02-08

Applicant: Gunter Moehler ,  Ralf Engelmann

Inventor： Gunter Moehler ,  Ralf Engelmann

IPC: G01J3/28

CPC classification number: G01J3/2803 ,  G01J3/36 ,  G02B21/0064 ,  G02B21/008

Abstract: The invention is directed to a laser scanning microscope with a detector device for spectrally resolving radiation detection. The detector device has at least one dispersive element, on which a beam of the radiation to be detected impinges and which fans out this beam spectrally, and at least two detector line arrays to which the spectrally fanned out radiation is directed and whose sensitivity is only adjustable in a unitary manner. At least two detector line arrays are provided in the detector device, each of them being irradiated by spectrally fanned out radiation of different spectral composition. The respective spectral composition of the radiation and the basic spectral sensitivity of the detector line arrays are taken into account in the sensitivity adjustment of the detector line arrays.

Abstract translation: 本发明涉及具有用于光谱分辨辐射检测的检测器装置的激光扫描显微镜。 检测器装置具有至少一个色散元件，待检测的辐射束撞击在该光束上，并且该光束在该光束上散射出光束;以及至少两个检测器线阵列，光谱扇出的辐射被引导到其上，并且其灵敏度仅为 可以整体调整。 在检测器装置中提供至少两个检测器线阵列，它们中的每一个被不同光谱组成的频谱扇形辐射照射。 在检测器线阵列的灵敏度调整中考虑辐射的各自的光谱组成和检测器线阵列的基本光谱灵敏度。

公开(公告)号：US07257289B2

公开(公告)日：2007-08-14

申请号：US10250152

申请日：2003-06-07

Applicant: Frank Olschewski

Inventor： Frank Olschewski

IPC: G02B6/26

CPC classification number: G01J3/36 ,  G01J3/2823 ,  G02B21/002

Abstract: A spectral scanning microscope and a method for data acquisition using a spectral scanning microscope are disclosed. A computer system is provided that encompasses a memory and a database. In combination with the computer system and/or the database, a continuous wavelength subregion that serves to illuminate the specimen can be selected from a continuous wavelength region using the spectral selection means. Also in combination with the computer system together with the spectral selection means, a detection band can be selected from the detected light beam.

Abstract translation: 公开了一种使用光谱扫描显微镜的光谱扫描显微镜和数据采集方法。 提供了包括存储器和数据库的计算机系统。 与计算机系统和/或数据库组合，可以使用频谱选择装置从连续波长区域中选择用于照射样本的连续波长子区域。 另外，与计算机系统一起与频谱选择装置一起，可以从检测到的光束中选择检测频带。

公开(公告)号：US07253897B2

公开(公告)日：2007-08-07

申请号：US10800320

申请日：2004-03-11

Applicant: John A. Moon ,  James S. Sirkis ,  Ralph Jones ,  Charles R. Winston ,  David R. Fournier ,  Joseph Pinto ,  Robert N. Brucato ,  James R. Dunphy ,  Christopher J. Chestnut

Inventor： John A. Moon ,  James S. Sirkis ,  Ralph Jones ,  Charles R. Winston ,  David R. Fournier ,  Joseph Pinto ,  Robert N. Brucato ,  James R. Dunphy ,  Christopher J. Chestnut

IPC: G01J3/06 ,  G01J3/18 ,  G01J3/30

CPC classification number: G01J3/06 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/18 ,  G01J3/28 ,  G01J3/32 ,  G01J3/36 ,  G01J2003/064 ,  G01J2003/1819 ,  G02B6/2931 ,  G02B6/4215 ,  H04B10/077 ,  H04B10/07955 ,  H04Q2011/0026 ,  H04Q2011/0049 ,  H04Q2011/0083

Abstract: An optical spectrum analyzer (OSA) 10 sequentially or selectively samples (or filters) a spectral band(s) 11 of light from a broadband optical input signal 12 and measures predetermined optical parameters of the optical signal (e.g., spectral profile) of the input light 12. The OSA 10 is a free-space optical device that includes a collimator assembly 15, a diffraction grating 20 and a mirror 22. A launch pigtail emits into free space the input signal through the collimator assembly 15 and onto the diffraction grating 20, which separates or spreads spatially the collimated input light, and reflects the dispersed light onto the mirror 22. A λ/4 plate 26 is disposed between the mirror 22 and the diffraction grating 20. The mirror reflects the separated light back through the λ/4 plate 26 to the diffraction grating 20, which reflects the light back through the collimating lens 18. The lens 18 focuses spectral bands of light (λ1–λN) at different focal points in space. One of the spectral bands 11 is focused onto a receive pigtail 28, which then propagates to a photodetector 30. A pivoting mechanism 34 pivots the diffraction grating 20 or mirror 22 about a pivot point 36 to sequentially or selectively focus each spectral band 11 to the receive pigtail 28. A position sensor 42 detects the displacement of the diffraction grating 24 or mirror.

Abstract translation: 光谱分析仪（OSA）10顺序地或选择性地从宽带光输入信号12采样（或滤波）光谱带11，并且测量输入的光信号的光学参数（例如，光谱分布） 光12。 OSA 10是包括准直器组件15，衍射光栅20和反射镜22的自由空间光学装置。 发射尾纤通过准直器组件15将输入信号发射到自由空间中，并在衍射光栅20上分散或扩展空间上准直的输入光，并将分散的光反射到反射镜22上。 λ/ 4板26设置在反射镜22和衍射光栅20之间。 反射镜通过λ/ 4板26将分离的光反射回到衍射光栅20，衍射光栅20将光反射通过准直透镜18。 透镜18在空间中的不同焦点处聚焦光的光谱带（λ1 SUB-N N N）。 光谱带11中的一个聚焦在接收尾纤28上，接收引线28然后传播到光电检测器30。 枢转机构34围绕枢转点36枢转衍射光栅20或反射镜22，以顺序地或选择性地将每个光谱带11聚焦到接收尾纤28。 位置传感器42检测衍射光栅24或反射镜的位移。

公开(公告)号：US20070171430A1

公开(公告)日：2007-07-26

申请号：US11624601

申请日：2007-01-18

Applicant: Guillermo J. Tearney ,  Brett E. Bouma ,  Aydogan Ozcan

Inventor： Guillermo J. Tearney ,  Brett E. Bouma ,  Aydogan Ozcan

IPC: G01B11/02

CPC classification number: G02B27/08 ,  G01J3/36 ,  G02B17/006 ,  G02B21/00 ,  G02B21/367 ,  G02B27/46

Abstract: Exemplary apparatus and method for obtaining information associated with at least one image of at least one portion of a sample can be provided. For example, at least one first electro-magnetic radiation can be provided from the at least one portion (e.g., using a first electro-magnetic radiation guiding arrangement which is configured to provide). A plurality of spatial frequency bands of the image associated with the first electro-magnetic radiation can be generated. Further, at least one second electro-magnetic radiation which is associated with the spatial frequency bands of the image can be received (e.g., using a second arrangement), and the image can be reconstructed based on the spatial frequency bands.

Abstract translation: 可以提供用于获得与样品的至少一部分的至少一个图像相关联的信息的示例性装置和方法。 例如，可以从至少一个部分（例如，使用配置为提供的第一电磁辐射引导装置）提供至少一个第一电磁辐射。 可以产生与第一电磁辐射相关联的图像的多个空间频带。 此外，可以接收与图像的空间频带相关联的至少一个第二电磁辐射（例如，使用第二布置），并且可以基于空间频带重建图像。

公开(公告)号：US07245374B2

公开(公告)日：2007-07-17

申请号：US10539193

申请日：2003-11-21

Applicant: Robert Frans Maria Hendriks

Inventor： Robert Frans Maria Hendriks

IPC: H01J40/14

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/3196 ,  G01N2201/129

Abstract: An optical analysis system (1), which is arranged to determine amplitude of a principal component of an optical signal, includes a first detector (5) for detecting the optical signal weighted by a first spectral weighting function, and a second detector (6) for detecting the optical signal weighted by a second spectral weighting function. For an improved signal-to-noise ratio, the optical analysis system (1) further includes a dispersive element (2) for spectrally dispersing the optical signal, and a distribution element (4) for receiving the spectrally dispersed optical signal and for distributing a first part of the optical signal weighted by the first spectral weighting function to the first detector (5) and a second part of the optical signal weighted by the second spectral weighting function to the second detector (6). The optical analysis system (1) is suited for use in numerous applications including a spectroscopic analysis system (30) and a blood analysis system (40).

Abstract translation: 被配置为确定光信号的主成分的幅度的光学分析系统（1）包括用于检测由第一光谱加权函数加权的光信号的第一检测器（5）和第二检测器（6） 用于检测由第二频谱加权函数加权的光信号。 为了提高信噪比，光学分析系统（1）还包括用于光谱分散光信号的色散元件（2）和用于接收光谱分散光信号并用于分配光信号的分布元件（4） 由第一光谱加权函数加权到第一检测器（5）的光信号的第一部分和由第二光谱加权函数加权到第二检测器（6）的光信号的第二部分。 光学分析系统（1）适用于许多应用，包括光谱分析系统（30）和血液分析系统（40）。

公开(公告)号：US20070153268A1

公开(公告)日：2007-07-05

申请号：US11650378

申请日：2007-01-05

Applicant: Janice Panza ,  John Maier ,  Jason Neiss

Inventor： Janice Panza ,  John Maier ,  Jason Neiss

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/28 ,  G01J3/36 ,  G01N15/1475 ,  G01N21/65 ,  G01N2015/1006 ,  G01N2015/1488 ,  G01N2021/656

Abstract: A system and method to distinguish normal cells from apoptotic cells. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference Raman data sets for normal cells and a second plurality of reference Raman data sets for apoptotic cells. A sample is irradiated with substantially monochromatic light generating a target Raman data set based on scattered photons. The target Raman data set is transformed into a vector space defined by the pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, apoptotic cells, and a combination of normal and apoptotic cells. The sample includes the step of treating the sample with a pharmaceutical agent prior to irradiating the sample. Based on the classification, the therapeutic efficiency of the pharmaceutical agent is assessed.

Abstract translation: 将正常细胞与凋亡细胞区分开的系统和方法。 选择预定矢量空间，其中矢量空间在数学上描述用于正常细胞的第一多个参考拉曼数据集和用于凋亡细胞的第二多个参考拉曼数据集。 用基本上单色的光照射样品，产生基于散射光子的目标拉曼数据集。 目标拉曼数据集被转换成由预定向量空间定义的向量空间。 在预定向量空间中分析变换数据的分布。 基于分析，样品被分类为含有正常细胞，凋亡细胞，以及正常细胞和凋亡细胞的组合。 样品包括在照射样品之前用药剂处理样品的步骤。 根据分类，评估药剂的治疗效果。